help button home button Endocrine Society Endocrinology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
This version published online on September 15, 2005
Endocrinology, doi:10.1210/en.2005-0972
A more recent version of this article appeared on January 1, 2006
This Article
Right arrow Author Manuscript (PDF)
Right arrow All Versions of this Article:
147/1/3    most recent
Author Manuscript (PDF)
Right arrow Purchase Article
Right arrow View Shopping Cart
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Copyright Permission
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by le Roux, C W
Right arrow Articles by Bloom, S R
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by le Roux, C W
Right arrow Articles by Bloom, S R

Submitted on August 1, 2005
Accepted on September 10, 2005

Attenuated peptide YY release in obese subjects is associated with reduced satiety

C W le Roux, R L Batterham, S JB Aylwin, M Patterson, C M Borg, K J Wynne, A Kent, R P Vincent, J Gardiner, M A Ghatei, and S R Bloom

Department of Metabolic Medicine, Dietetics, Hammersmith Hospital, Imperial College London, UK; Department of Endocrinology, University College London UK; Department of Endocrinology, King's College Hospital, London, UK

The responses of the gut hormone, peptide YY (PYY), to food were investigated in twenty normal weight and twenty obese humans in response to six test meals of varying calorie content. Human volunteers had a graded rise in plasma PYY (R2=0.96, P < 0.001) during increasing calorific meals, but the obese subjects had a lower endogenous PYY response at each meal size (P < 0.05 at all levels). The ratio of plasma PYY1-36 to PYY3-36 was similar in normal weight and obese subjects. The effect on food intake and satiety of graded doses of exogenous PYY3-36 was also evaluated in twelve human volunteers. Stepwise increasing doses of exogenous PYY3-36 in humans caused a graded reduction in food intake (R2=0.38, P < 0.001). In high fat fed (HF) mice that became obese and low fat fed (LF) mice that remained normal weight, we measured plasma PYY, tissue PYY and PYY mRNA levels and assessed the effect of exogenous administered PYY3-36 on food intake in HF mice. HF fed mice remained sensitive to the anorectic effects of exogenous intraperitoneal PYY3-36. Compared with LF fed mice, the HF fed mice had lower endogenous plasma PYY, higher tissue PYY, but similar PYY mRNA levels, suggesting a possible reduction of PYY release. Thus, fasting and postprandial endogenous plasma PYY levels were attenuated in obese humans and rodents. The PYY3-36 infusion study showed that the degree of plasma PYY reduction in obese subjects were likely associated with decreased satiety and relatively increased food intake. We conclude that obese subjects have a PYY deficiency that would reduce satiety and could thus reinforce their obesity.




This article has been cited by other articles:


Home page
 J. Clin. Pathol.Home page
R P Vincent and C W le Roux
The satiety hormone peptide YY as a regulator of appetite
J. Clin. Pathol., May 1, 2008; 61(5): 548 - 552.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Interv.Home page
S. R. Bloom, F. P. Kuhajda, I. Laher, X. Pi-Sunyer, G. V. Ronnett, T. M.M. Tan, and D. S. Weigle
The Obesity Epidemic: Pharmacological Challenges
Mol. Interv., April 1, 2008; 8(2): 82 - 98.
[Abstract] [Full Text] [PDF]

Home page
 Diabetes CareHome page
O. B. Chaudhri, K. Wynne, and S. R. Bloom
Can Gut Hormones Control Appetite and Prevent Obesity?
Diabetes Care, February 1, 2008; 31(Supplement_2): S284 - S289.
[Abstract] [Full Text] [PDF]

Home page
 Ann Clin BiochemHome page
C. W le Roux, C. M Borg, K. G Murphy, R. P Vincent, M. A Ghatei, and S. R Bloom
Supraphysiological doses of intravenous PYY3-36 cause nausea, but no additional reduction in food intake
Ann Clin Biochem, January 1, 2008; 45(1): 93 - 95.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Clin. Nutr.Home page
L. J Moran, M. Noakes, P. M Clifton, G. A Wittert, C. W Le Roux, M. A Ghatei, S. R Bloom, and R. J Norman
Postprandial ghrelin, cholecystokinin, peptide YY, and appetite before and after weight loss in overweight women with and without polycystic ovary syndrome
Am. J. Clinical Nutrition, December 1, 2007; 86(6): 1603 - 1610.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
M. H. Tschop and E. Ravussin
Peptide YY: obesity's cause and cure?
Am J Physiol Endocrinol Metab, November 1, 2007; 293(5): E1131 - E1133.
[Full Text] [PDF]

Home page
 EndocrinologyHome page
G. L. Rahardjo, X.-F. Huang, Y. Y. Tan, and C. Deng
Decreased Plasma Peptide YY Accompanied by Elevated Peptide YY and Y2 Receptor Binding Densities in the Medulla Oblongata of Diet-Induced Obese Mice
Endocrinology, October 1, 2007; 148(10): 4704 - 4710.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Clin. Nutr.Home page
T. J Little, M. Horowitz, and C. Feinle-Bisset
Modulation by high-fat diets of gastrointestinal function and hormones associated with the regulation of energy intake: implications for the pathophysiology of obesity
Am. J. Clinical Nutrition, September 1, 2007; 86(3): 531 - 541.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
B. Sloth, L. Davidsen, J. J. Holst, A. Flint, and A. Astrup
Effect of subcutaneous injections of PYY1-36 and PYY3-36 on appetite, ad libitum energy intake, and plasma free fatty acid concentration in obese males
Am J Physiol Endocrinol Metab, August 1, 2007; 293(2): E604 - E609.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
P. K. Chelikani, A. C. Haver, and R. D. Reidelberger
Intermittent intraperitoneal infusion of peptide YY(3-36) reduces daily food intake and adiposity in obese rats
Am J Physiol Regulatory Integrative Comp Physiol, July 1, 2007; 293(1): R39 - R46.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
I. Gantz, N. Erondu, M. Mallick, B. Musser, R. Krishna, W. K. Tanaka, K. Snyder, C. Stevens, M. A. Stroh, H. Zhu, et al.
Efficacy and Safety of Intranasal Peptide YY3-36 for Weight Reduction in Obese Adults
J. Clin. Endocrinol. Metab., May 1, 2007; 92(5): 1754 - 1757.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
B. Sloth, J. J. Holst, A. Flint, N. T. Gregersen, and A. Astrup
Effects of PYY1-36 and PYY3-36 on appetite, energy intake, energy expenditure, glucose and fat metabolism in obese and lean subjects
Am J Physiol Endocrinol Metab, April 1, 2007; 292(4): E1062 - E1068.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
P. T. Pfluger, J. Kampe, T. R. Castaneda, T. Vahl, D. A. D'Alessio, T. Kruthaupt, S. C. Benoit, U. Cuntz, H. J. Rochlitz, M. Moehlig, et al.
Effect of Human Body Weight Changes on Circulating Levels of Peptide YY and Peptide YY3-36
J. Clin. Endocrinol. Metab., February 1, 2007; 92(2): 583 - 588.
[Abstract] [Full Text] [PDF]

Home page
 Endocr. Rev.Home page
K. G. Murphy, W. S. Dhillo, and S. R. Bloom
Gut Peptides in the Regulation of Food Intake and Energy Homeostasis
Endocr. Rev., December 1, 2006; 27(7): 719 - 727.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Gastrointest. Liver Physiol.Home page
N. Rozengurt, S. V. Wu, M. C. Chen, C. Huang, C. Sternini, and E. Rozengurt
Colocalization of the {alpha}-subunit of gustducin with PYY and GLP-1 in L cells of human colon
Am J Physiol Gastrointest Liver Physiol, November 1, 2006; 291(5): G792 - G802.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
J.-P. Chanoine
Individual Differences in the Hormonal Control of Appetite: A Step toward a (More) Successful Treatment of Childhood Overweight?
J. Clin. Endocrinol. Metab., August 1, 2006; 91(8): 2864 - 2866.
[Full Text] [PDF]

Home page
 EndocrinologyHome page
A. A. Young
Obesity: A Peptide YY-Deficient, But Not Peptide YY- Resistant, State
Endocrinology, January 1, 2006; 147(1): 1 - 2.
[Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
Endocrinology Endocrine Reviews J. Clin. End. & Metab.
Molecular Endocrinology Recent Prog. Horm. Res. All Endocrine Journals
Copyright © 2005 by The Endocrine Society