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This version published online on October 6, 2005
Endocrinology, doi:10.1210/en.2005-1048
A more recent version of this article appeared on January 1, 2006
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Submitted on August 16, 2005
Accepted on September 29, 2005

Effects of Central Infusion of Ghrelin on Food Intake and Plasma Levels of Growth Hormone, Luteinizing Hormone, Prolactin, and Cortisol Secretion in Sheep

Javed Iqbal, Yohei Kurose, Benedict Canny, and Iain J. Clarke*

Prince Henry's Institute of Medical Research, P.O. Box 5152, Clayton VIC 3168, Australia, Laboratory of Animal Nutrient Metabolism, Kitasato University, Higashi 23-35-1, Towada, Aomori 034, Japan, Dept of Physiology, P O Box 13F, Monash University, VIC 3800, Australia

* To whom correspondence should be addressed. E-mail: iain.clarke{at}med.monash.edu.au.

Ghrelin is an endogenous ligand for the growth hormone secretagogue/ghrelin receptor (GHS-R) and stimulates feeding behavior and growth hormone (GH) levels in rodents and humans. A pre-prandial increase in plasma ghrelin levels is seen in sheep on programed feeding, followed by a post-prandial rise in plasma GH levels, but effects on food intake and endocrine function are not defined in this ruminant species. We administered ghrelin to female sheep in various modes and measured effects on voluntary food intake (VFI) and plasma levels of GH, LH (LH), prolactin (PRL) and cortisol. Whether administered intracerebroventricularly or intravenously, ghrelin consistently failed to stimulate VFI. On the other hand, ghrelin invariably increased plasma GH levels and DAP-octanoyl3 human ghrelin was more potent than ovine ghrelin. Bolus injection of ghrelin into the third cerebral ventricle reduced plasma LH levels but did not affect levels of PRL or cortisol. These findings suggested that the pre-prandial rise in plasma ghrelin that is seen in sheep on programed feeding does not influence VFI, but is likely to be important in the post-prandial rise in GH levels. Thus, ghrelin does not appear to be a significant regulator of ingestive behavior in this species of ruminant, but acts centrally to control indirectly regulate GH and LH secretion.
Key words: appetite • hypothalamus • pituitary • neuroendocrinology




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