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This version published online on April 20, 2006
Endocrinology, doi:10.1210/en.2005-1665
A more recent version of this article appeared on July 1, 2006
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Submitted on December 29, 2005
Accepted on April 11, 2006

Mining the Mouse Transcriptome of Receptive Endometrium Reveals Distinct Molecular Signatures for the Luminal and Glandular Epithelium

Andrea L. Niklaus and Jeffrey W. Pollard*

Departments of Development and Molecular Biology and Obstetrics and Gynecology and Women's Health, Center for the Study of Reproductive Biology and Women's Health, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, New York, 10461, USA

* To whom correspondence should be addressed. E-mail: pollard{at}aecom.yu.edu.

Epithelia coat most tissues where they sense and respond to the environment and participate in innate immune responses. In the adult mouse uterus, columnar epithelium lines the central lumen and the glands that penetrate the underlying stroma. A nidatory surge of estrogen causes differentiation of the luminal epithelium to the receptive state that permits blastocyst attachment and allows subsequent implantation. Here, using laser capture micro-dissection to isolate the luminal and glandular epithelia separately, we have profiled gene expression two hrs before embryo attachment to determine if there are unique roles for these two epithelial structures in this process. While most genes were expressed in both compartments, there was greater expression of 153 and 118 genes in the lumen and glands respectively. In the luminal epithelium there is enrichment in lipid, metal-ion binding and carbohydrate metabolizing enzymes while in the glands immune response genes are emphasized. In situ hybridization to uterine sections obtained from mice during the pre-implantation period, validated these data and indicated an array of previously undocumented genes expressed with unique patterns in these epithelia. The data show that each epithelial compartment has a distinct molecular signature and that they act differentially and synergistically to permit blastocyst implantation.




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