| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH |
| |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Submitted on May 16, 2006
Accepted on November 8, 2006
Research Centre for Reproductive Health, Discipline of Obstetrics and Gynaecology, School of Paediatrics and Reproductive Health, University of Adelaide, Adelaide, SA, 5005, Australia; Discipline of Physiology, School of Molecular Biosciences, University of Adelaide, Adelaide, SA, 5005, Australia
* To whom correspondence should be addressed. E-mail: julie.owens{at}adelaide.edu.au.
Most children who are short or light at birth due to intrauterine growth restriction (IUGR) exhibit accelerated growth in infancy, termed "catch-up" growth, which together with IUGR, predicts increased risk of type 2 diabetes and obesity later in life. Placental restriction in sheep reduces size at birth and also causes catch-up growth and increased adiposity at 6 weeks of age. The physiological mechanisms responsible for catch-up growth after IUGR and its links to these adverse sequelae are unknown. Because insulin is a major anabolic hormone of infancy and its actions are commonly perturbed in these related disorders, we hypothesized that restriction of fetal growth would alter insulin secretion and sensitivity in the juvenile sheep at one month, which would be related to their altered growth and adiposity. We show that placental restriction impairs glucose-stimulated insulin production, but not fasting insulin abundance or production in the young sheep. However, insulin sensitivity of circulating free fatty acids, and insulin disposition indices for glucose and free fatty acids are increased by placental restriction. Catch-up growth is predicted by the insulin disposition indices for amino acids and free fatty acids, and adiposity by that for free fatty acids. This suggests that catch-up growth and early onset visceral obesity following IUGR may have a common underlying cause, that of increased insulin action due primarily to enhanced insulin sensitivity, which could account in part for their links to adverse metabolic and related outcomes in later life.
This article has been cited by other articles:
 |
|
 |
|
  K. L. Gatford, S. N. B. Mohammad, M. L. Harland, M. J. De Blasio, A. L. Fowden, J. S. Robinson, and J. A. Owens Impaired {beta}-Cell Function and Inadequate Compensatory Increases in {beta}-Cell Mass after Intrauterine Growth Restriction in Sheep Endocrinology, October 1, 2008; 149(10): 5118 - 5127. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. L. Siebel, A. Mibus, M. J. De Blasio, K. T. Westcott, M. J. Morris, L. Prior, J. A. Owens, and M. E. Wlodek Improved Lactational Nutrition and Postnatal Growth Ameliorates Impairment of Glucose Tolerance by Uteroplacental Insufficiency in Male Rat Offspring Endocrinology, June 1, 2008; 149(6): 3067 - 3076. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. D. Wadley, A. L. Siebel, G. J. Cooney, G. K. McConell, M. E. Wlodek, and J. A. Owens Uteroplacental insufficiency and reducing litter size alters skeletal muscle mitochondrial biogenesis in a sex-specific manner in the adult rat Am J Physiol Endocrinol Metab, May 1, 2008; 294(5): E861 - E869. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. A. Duffield, T. Vuocolo, R. Tellam, B. S. Yuen, B. S. Muhlhausler, and I. C. McMillen Placental restriction of fetal growth decreases IGF1 and leptin mRNA expression in the perirenal adipose tissue of late gestation fetal sheep Am J Physiol Regulatory Integrative Comp Physiol, May 1, 2008; 294(5): R1413 - R1419. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Ibanez, L. Suarez, A. Lopez-Bermejo, M. Diaz, C. Valls, and F. de Zegher Early Development of Visceral Fat Excess after Spontaneous Catch-Up Growth in Children with Low Birth Weight J. Clin. Endocrinol. Metab., March 1, 2008; 93(3): 925 - 928. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. L. Hui, C. M. Schooling, S. S. L. Leung, K. H. Mak, L. M. Ho, T. H. Lam, and G. M. Leung Birth Weight, Infant Growth, and Childhood Body Mass Index: Hong Kong's Children of 1997 Birth Cohort Arch Pediatr Adolesc Med, March 1, 2008; 162(3): 212 - 218. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. S. Gilbert, E. Brandon, and T. Vera Fetal insulin secretion in late gestation: does size matter? J. Physiol., December 15, 2007; 585(3): 651 - 652. [Full Text] [PDF]
|
|
|
|
|
|
S. W. Limesand, P. J. Rozance, D. Smith, and W. W. Hay Jr. Increased insulin sensitivity and maintenance of glucose utilization rates in fetal sheep with placental insufficiency and intrauterine growth restriction Am J Physiol Endocrinol Metab, December 1, 2007; 293(6): E1716 - E1725. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. A. Owens, K. L. Gatford, M. J. De Blasio, L. J. Edwards, I. C. McMillen, and A. L. Fowden Restriction of placental growth in sheep impairs insulin secretion but not sensitivity before birth J. Physiol., November 1, 2007; 584(3): 935 - 949. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. M. Wallace, J. S. Milne, R. P. Aitken, and W. W. Hay Jr. Sensitivity to metabolic signals in late-gestation growth-restricted fetuses from rapidly growing adolescent sheep Am J Physiol Endocrinol Metab, November 1, 2007; 293(5): E1233 - E1241. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. A. Owens, P. Thavaneswaran, M. J. De Blasio, I. C. McMillen, J. S. Robinson, and K. L. Gatford Sex-specific effects of placental restriction on components of the metabolic syndrome in young adult sheep Am J Physiol Endocrinol Metab, June 1, 2007; 292(6): E1879 - E1889. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH |
| Endocrinology | Endocrine Reviews | J. Clin. End. & Metab. |
| Molecular Endocrinology | Recent Prog. Horm. Res. | All Endocrine Journals |
