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This version published online on September 7, 2006
Endocrinology, doi:10.1210/en.2006-0689
A more recent version of this article appeared on December 1, 2006
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Submitted on May 23, 2006
Accepted on August 30, 2006

Selenium-dependent pre- and posttranscriptional mechanisms are responsible for sexual dimorphic expression of selenoproteins in murine tissues

Cornelia Riese, Marten Michaelis, Birgit Mentrup, Franziska Götz, Josef Köhrle, Ulrich Schweizer, and Lutz Schomburg*

Institute for Experimental Endocrinology, Charité - Universitaetsmedizin Berlin, Germany

* To whom correspondence should be addressed. E-mail: lutz.schomburg{at}charite.de.

Important enzymes for thyroid hormone metabolism, antioxidative defense and intracellular redox control contain selenocysteine (Sec) in their active centers. Expression of these selenoproteins is tightly controlled and a sex-specific phenotype is observed upon disturbance of Se transport in mice. Therefore, we analyzed Se concentrations and expression levels of several selenoproteins including type I iodothyronine deiodinase (Dio1) and glutathione peroxidase (GPx) isozymes in male and female mice. On regular lab chow, serum Se levels were comparable but serum GPx3 activity was higher in females than in males (1.3-fold). Selenoprotein P (SePP) mRNA levels were higher in livers (1.3-fold) and lower in kidneys (to 31%) in female compared with male mice. Orchidectomy alleviated the sex-specific differences in SePP mRNA amounts indicating modulatory effects of androgens on SePP expression. Female mice expressed higher levels of Dio1 mRNA in kidney (2.6-fold) and liver (1.4-fold) in comparison to male mice. This sexual dimorphic expression of Dio1 mRNA was paralleled by increased Dio1 activity in female kidney (1.8-fold), but not in liver where males expressed higher Dio1 activity (2.8-fold). Interestingly, Se deficiency decreased Dio1 activity more effectively in males than in females and resulting hepatic enzyme levels were then comparable between the sexes. At the same time, the sex-specific difference of Dio1 activity widened in kidney. Orchidectomy or estradiol treatment of ovariectomized females impacted stronger on renal than hepatic Dio1 expression. Thus, we conclude that Se-dependent posttranscriptional mechanisms are operational which either affect translational efficiency or Dio1 stability in a sex- and tissue-specific manner.
Key words: gender • trace element • translational efficiency • stability • deiodinase




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