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This version published online on August 31, 2006
Endocrinology, doi:10.1210/en.2006-0826
A more recent version of this article appeared on December 1, 2006
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Submitted on June 19, 2006
Accepted on July 13, 2006

ALDOSTERONE AND THE CARDIOVASCULAR SYSTEM: GENOMIC AND NONGENOMIC EFFECTS

John W. Funder*

Prince Henry's Institute of Medical Research, P.O. Box 5152, Clayton, Victoria, Australia 3168

* To whom correspondence should be addressed. E-mail: john.funder{at}princehenrys.org.

There is clear evidence for rapid nongenomic effects of aldosterone in the cardiovascular system, in addition to its well characterized effects of unidirectional transepithelial sodium transport. Many of these effects are mediated by the classical mineralocorticoid receptors, though others may be exerted independently. Given that mineralocorticoid receptors are largely constitutively occupied but not activated by physiologic glucocorticoids, effects of aldosterone administered in vitro or in vivo may or may not equate with true physiologic mineralocorticoid roles. In many systems (e.g. blood pressure regulation, cardiac fibrosis) the time course of effects is such that it is not possible - and perhaps not important - to distinguish between rapid nongenomic and classical genomic effects in the context of homeostatic physiology.




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