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This version published online on May 24, 2007
Endocrinology, doi:10.1210/en.2007-0505
A more recent version of this article appeared on September 1, 2007
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Submitted on April 19, 2007
Accepted on May 17, 2007

PIG CONCEPTUSES SECRETE ESTROGEN AND INTERFERONS TO DIFFERENTIALLY REGULATE UTERINE STAT1 IN A TEMPORAL AND CELL-TYPE SPECIFIC MANNER

Margaret M. Joyce, Robert C. Burghardt, Rodney D. Geisert, James R. Burghardt, R. Neil Hooper, Jason W. Ross, Morgan D. Ashworth, and Greg A. Johnson*

Center for Animal Biotechnology and Genomics, Department of Veterinary Integrative Bioscience, Department of Large Animal Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, TX 77843-4458, Department of Animal Science, College of Agriculture, Food and Natural Resources, University of Missouri-Columbia, Columbia, MO 65211, and Department of Animal Science, Oklahoma State University, Stillwater, OK 74078

* To whom correspondence should be addressed. E-mail: gjohnson{at}cvm.tamu.edu.

Conceptus trophectoderm and uterine luminal epithelial (LE) cells interact via endocrine, paracrine and autocrine modulators to mediate pregnancy recognition and implantation. Pig conceptuses release estrogens for pregnancy recognition, but also secrete interferons during implantation. Since interferon stimulated genes (ISGs) are increased by interferons secreted for pregnancy recognition in ruminants, we asked if the ISG, STAT1, is upregulated in pig endometrium by conceptus estrogens and/or interferons. STAT1 expression in response to day of pregnancy, estrogen injection and intrauterine infusion of conceptus secretory proteins (CSP) in pigs indicated: i) estrogen increases STAT1 in LE; ii) CSP that contain interferons increase STAT1 in stroma; iii) STAT1 increases in close proximity to the conceptus; and iv) early estrogen results in conceptus death and no STAT1 in stroma. The interactions of estrogen and interferons to regulate cell-type specific expression of STAT1 highlight the complex interplay between endometrium and conceptus for pregnancy recognition and implantation.
Key words: Pig • conceptus • uterus • interferons • estrogen • STAT1




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[Abstract] [Full Text] [PDF]


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