The effects of peripheral glucagon like peptide-1 receptor (GLP-1R) stimulation on feeding, gastric emptying and energetic responses involve vagal transmission and CNS processing. Despite a lack of studies aimed at determining which CNS regions are critical for the GLP-1R response production, hypothalamic/forebrain processing is regarded as essential for these effects. Here the contribution of the caudal brainstem to the control of food intake, core temperature, heart rate, and gastric emptying responses generated by peripheral delivery of the GLP-1R agonist, Exendin-4 (Ex-4), was assessed by comparing responses of chronic supracollicular decerebrate (CD) rats to those of pair-fed intact control rats. Responses driven by hindbrain intracerebroventricular (4^th icv) delivery of Ex-4 were also evaluated. IP Ex-4 (1.2 and 3.0 µg/kg) suppressed glucose intake in both CDs (5.0 ± 1.2 and 4.4 ± 1.1 ml ingested) and controls (9.4 ± 1.5 and 7.7 ± 0.8 ml ingested) compared to intakes following vehicle injections (13.1 ± 2.5 and 13.2 ± 1.7 ml ingested, respectively). Hindbrain ventricular Ex-4 (0.3 µg) also suppressed food intake in CDs (4.7 ± 0.6 ml ingested) and controls (11.0 ± 2.9 ml ingested) compared to vehicle intakes (9.3 ± 2.1 and 19.3 ± 4.3 ml ingested, respectively). IP Ex-4 (0.12, 1.2, 2.4 µg/kg) reduced gastric emptying rates in a dose-related manner similarly for both CD and control rats. Hypothermia followed IP and 4^th icv Ex-4 in awake, behaving controls (0.6 and 1.0 C avg. suppression) and CDs (1.5 and 2.5 C avg. suppression). IP Ex-4 triggered tachycardia in both control and CDs. Results demonstrate that caudal brainstem processing is sufficient for mediating the suppression of intake, core temperature, and gastric emptying rates, as well as tachycardia triggered by peripheral GLP-1R activation and also by hindbrain-delivered ligand. Contrary to the literature, hypothalamic/forebrain processing and forebrain-caudal brainstem communication is not required for the observed responses.