NEWS & VIEWS:

Michael E. Baker

Evolution of Glucocorticoid and Mineralocorticoid Responses: Go Fish
Endocrinology 2003 144: 4223-4225, doi:10.1210/en.2003-0843 [Full Text] [PDF]  

Donald P. McDonnell

Mining the Complexities of the Estrogen Signaling Pathways for Novel Therapeutics
Endocrinology 2003 144: 4237-4240, doi:10.1210/en.2003-0900 [Full Text] [PDF]  

Denise P. Carvalho

Modulation of Uterine Iodothyronine Deiodinases—A Critical Event for Fetal Development?
Endocrinology 2003 144: 4250-4252, doi:10.1210/en.2003-0848 [Full Text] [PDF]  

William L. Lowe, Jr.

"The Matrix Unloaded": Implications for Cytokine Signaling in Islets?
Endocrinology 2003 144: 4262-4263, doi:10.1210/en.2003-0884 [Full Text] [PDF]  

BRIEF COMMUNICATIONS:

Andrew L. Siebel, Helen M. Gehring, Irna Grace T. Reytomas, and Laura J. Parry

Inhibition of Oxytocin Receptor and Estrogen Receptor- Expression, But Not Relaxin Receptors (LGR7), in the Myometrium of Late Pregnant Relaxin Gene Knockout Mice
Endocrinology 2003 144: 4272-4275, doi:10.1210/en.2003-0548 [Abstract] [Full Text] [PDF]  

Itay Bentov, Derek LeRoith, and Haim Werner

The WT1 Wilms’ Tumor Suppressor Gene: A Novel Target for Insulin-Like Growth Factor-I Action
Endocrinology 2003 144: 4276-4279, doi:10.1210/en.2003-0400 [Abstract] [Full Text] [PDF]  

Wei Zhou, Irwin Park, Michael Pins, James M. Kozlowski, Borko Jovanovic, Ju Zhang, Chung Lee, and Kenneth Ilio

Dual Regulation of Proliferation and Growth Arrest in Prostatic Stromal Cells by Transforming Growth Factor-ß1
Endocrinology 2003 144: 4280-4284, doi:10.1210/en.2003-0554 [Abstract] [Full Text] [PDF]  

Patricia Jimenez, Karla Saner, Bobbie Mayhew, and William E. Rainey

GATA-6 Is Expressed in the Human Adrenal and Regulates Transcription of Genes Required for Adrenal Androgen Biosynthesis
Endocrinology 2003 144: 4285-4288, doi:10.1210/en.2003-0472 [Abstract] [Full Text] [PDF]  

CANCER:

Rodolfo A. Medina, Ana Maria Meneses, Juan Carlos Vera, Catherine Guzman, Francisco Nualart, Allisson Astuya, María de los Angeles García, Sumie Kato, Andrés Carvajal, Mauricio Pinto, and Gareth I. Owen

Estrogen and Progesterone Up-Regulate Glucose Transporter Expression in ZR-75-1 Human Breast Cancer Cells
Endocrinology 2003 144: 4527-4535, doi:10.1210/en.2003-0294 [Abstract] [Full Text] [PDF]  

Jonna Frasor, Jeanne M. Danes, Barry Komm, Ken C. N. Chang, C. Richard Lyttle, and Benita S. Katzenellenbogen

Profiling of Estrogen Up- and Down-Regulated Gene Expression in Human Breast Cancer Cells: Insights into Gene Networks and Pathways Underlying Estrogenic Control of Proliferation and Cell Phenotype
Endocrinology 2003 144: 4562-4574, doi:10.1210/en.2003-0567 [Abstract] [Full Text] [PDF]  

Helai P. Mohammad, Rula A. Abbud, Al F. Parlow, Jonathan S. Lewin, and John H. Nilson

Targeted Overexpression of Luteinizing Hormone Causes Ovary-Dependent Functional Adenomas Restricted to Cells of the Pit-1 Lineage
Endocrinology 2003 144: 4626-4636, doi:10.1210/en.2003-0357 [Abstract] [Full Text] [PDF]  

CRH-ACTH-POMC-ADRENAL:

I. Goshen, R. Yirmiya, K. Iverfeldt, and J. Weidenfeld

The Role of Endogenous Interleukin-1 in Stress-Induced Adrenal Activation and Adrenalectomy-Induced Adrenocorticotropic Hormone Hypersecretion
Endocrinology 2003 144: 4453-4458, doi:10.1210/en.2003-0338 [Abstract] [Full Text] [PDF]  

E. Beéry, P. Middel, A. Bahn, H. S. Willenberg, Y. Hagos, H. Koepsell, S. R. Bornstein, G. A. Müller, G. Burckhardt, and J. Steffgen

Molecular Evidence of Organic Ion Transporters in the Rat Adrenal Cortex with Adrenocorticotropin-Regulated Zonal Expression
Endocrinology 2003 144: 4519-4526, doi:10.1210/en.2002-221001 [Abstract] [Full Text] [PDF]  

Olivier Féraud, Christine Mallet, and Isabelle Vilgrain

Expressional Regulation of the Angiopoietin-1 and -2 and the Endothelial-Specific Receptor Tyrosine Kinase Tie2 in Adrenal Atrophy: A Study of Adrenocorticotropin-Induced Repair
Endocrinology 2003 144: 4607-4615, doi:10.1210/en.2003-0099 [Abstract] [Full Text] [PDF]  

ENERGY BALANCE/OBESITY:

András K. Fülöp, Anna Földes, Edit Buzás, Krisztina Hegyi, Ildikó H. Miklós, László Romics, Monika Kleiber, András Nagy, András Falus, and Krisztina J. Kovács

Hyperleptinemia, Visceral Adiposity, and Decreased Glucose Tolerance in Mice with a Targeted Disruption of the Histidine Decarboxylase Gene
Endocrinology 2003 144: 4306-4314, doi:10.1210/en.2003-0222 [Abstract] [Full Text] [PDF]  

Ya-Xiong Tao and Deborah L. Segaloff

Functional Characterization of Melanocortin-4 Receptor Mutations Associated with Childhood Obesity
Endocrinology 2003 144: 4544-4551, doi:10.1210/en.2003-0524 [Abstract] [Full Text] [PDF]  

José Miguel Cerdá-Reverter and Richard Ector Peter

Endogenous Melanocortin Antagonist in Fish: Structure, Brain Mapping, and Regulation by Fasting of the Goldfish Agouti-Related Protein Gene
Endocrinology 2003 144: 4552-4561, doi:10.1210/en.2003-0453 [Abstract] [Full Text] [PDF]  

GENERAL ENDOCRINOLOGY:

Sandra Incerpi, Silvia D’Arezzo, Maria Marino, Roberto Musanti, Valentina Pallottini, Andrea Pascolini, and Anna Trentalance

Short-Term Activation by Low 17ß-Estradiol Concentrations of the Na⁺/H⁺ Exchanger in Rat Aortic Smooth Muscle Cells: Physiopathological Implications
Endocrinology 2003 144: 4315-4324, doi:10.1210/en.2003-0495 [Abstract] [Full Text] [PDF]  

Mina Desai, Catalina Guerra, Shengbiao Wang, and Michael G. Ross

Programming of Hypertonicity in Neonatal Lambs: Resetting of the Threshold for Vasopressin Secretion
Endocrinology 2003 144: 4332-4337, doi:10.1210/en.2003-0200 [Abstract] [Full Text] [PDF]  

Frank Callies, Hinrik Strömer, Robert H. G. Schwinger, Birgit Bölck, Kai Hu, Stefan Frantz, Andrea Leupold, Stephanie Beer, Bruno Allolio, and Andreas W. Bonz

Administration of Testosterone Is Associated with a Reduced Susceptibility to Myocardial Ischemia
Endocrinology 2003 144: 4478-4483, doi:10.1210/en.2003-0058 [Abstract] [Full Text] [PDF]  

GROWTH FACTORS-CYTOKINES-ONCOGENES:

Sally L. Mellor, Emma M. A. Ball, Anne E. O’Connor, Jean-François Ethier, Mark Cranfield, Jacqueline F. Schmitt, David J. Phillips, Nigel P. Groome, and Gail P. Risbridger

Activin ß_C-Subunit Heterodimers Provide a New Mechanism of Regulating Activin Levels in the Prostate
Endocrinology 2003 144: 4410-4419, doi:10.1210/en.2003-0225 [Abstract] [Full Text] [PDF]  

Gary A. Ulaner, Youwen Yang, Ji-Fan Hu, Tao Li, Thanh H. Vu, and Andrew R. Hoffman

CTCF Binding at the Insulin-Like Growth Factor-II (IGF2)/H19 Imprinting Control Region Is Insufficient to Regulate IGF2/H19 Expression in Human Tissues
Endocrinology 2003 144: 4420-4426, doi:10.1210/en.2003-0681 [Abstract] [Full Text] [PDF]  

INSULIN-GLUCAGON-GI PEPTIDES-DIABETES MELLITUS:

Natalie A. Walsh, Bernardo Yusta, Mark P. DaCambra, Younes Anini, Daniel J. Drucker, and Patricia L. Brubaker

Glucagon-Like Peptide-2 Receptor Activation in the Rat Intestinal Mucosa
Endocrinology 2003 144: 4385-4392, doi:10.1210/en.2003-0309 [Abstract] [Full Text] [PDF]  

Rajesh H. Amin, Hai-Qing Chen, Rajakrishnan Veluthakal, Robert B. Silver, Jingsong Li, GuoDong Li, and Anjaneyulu Kowluru

Mastoparan-Induced Insulin Secretion from Insulin-Secreting ßTC3 and INS-1 Cells: Evidence for Its Regulation by Rho Subfamily of G Proteins
Endocrinology 2003 144: 4508-4518, doi:10.1210/en.2003-0106 [Abstract] [Full Text] [PDF]  

INTRACELLULAR SIGNAL SYSTEMS:

Matilde Todaro, Francesca Di Gaudio, Marialuisa Lavitrano, Giorgio Stassi, and Gianpaolo Papaccio

Islet ß-Cell Apoptosis Triggered in Vivo by Interleukin-1ß Is Not Related to the Inducible Nitric Oxide Synthase Pathway: Evidence for Mitochondrial Function Impairment and Lipoperoxidation
Endocrinology 2003 144: 4264-4271, doi:10.1210/en.2003-0385 [Abstract] [Full Text] [PDF]  

A. D’Alessio, D. Califano, M. Incoronato, G. Santelli, T. Florio, G. Schettini, M. S. Carlomagno, L. Cerchia, and V. de Franciscis

The Tyrosine Phosphatase Shp-2 Mediates Intracellular Signaling Initiated by Ret Mutants
Endocrinology 2003 144: 4298-4305, doi:10.1210/en.2003-0620 [Abstract] [Full Text] [PDF]  

Tusty-Jiuan Hsieh, Pierre Fustier, Shao-Ling Zhang, Janos G. Filep, Shiow-Shih Tang, Julie R. Ingelfinger, I. George Fantus, Pavel Hamet, and John S. D. Chan

High Glucose Stimulates Angiotensinogen Gene Expression and Cell Hypertrophy via Activation of the Hexosamine Biosynthesis Pathway in Rat Kidney Proximal Tubular Cells
Endocrinology 2003 144: 4338-4349, doi:10.1210/en.2003-0220 [Abstract] [Full Text] [PDF]  

Jan A. Ehses, Vanbric R. Casilla, Tim Doty, J. Andrew Pospisilik, Kyle D. Winter, Hans-Ulrich Demuth, Raymond A. Pederson, and Christopher H. S. McIntosh

Glucose-Dependent Insulinotropic Polypeptide Promotes ß-(INS-1) Cell Survival via Cyclic Adenosine Monophosphate-Mediated Caspase-3 Inhibition and Regulation of p38 Mitogen-Activated Protein Kinase
Endocrinology 2003 144: 4433-4445, doi:10.1210/en.2002-0068 [Abstract] [Full Text] [PDF]  

Ho Y. Yeung, Daniel K. O. Chan, Nai K. Mak, Graham F. Wagner, and Chris K. C. Wong

Identification of Signal Transduction Pathways that Modulate Dibutyryl Cyclic Adenosine Monophosphate Activation of Stanniocalcin Gene Expression in Neuroblastoma Cells
Endocrinology 2003 144: 4446-4452, doi:10.1210/en.2003-0504 [Abstract] [Full Text] [PDF]  

Nathalie Lalevée, Véronique Resin, Serge Arnaudeau, Nicolas Demaurex, and Michel F. Rossier

Intracellular Transport of Calcium from Plasma Membrane to Mitochondria in Adrenal H295R Cells: Implication for Steroidogenesis
Endocrinology 2003 144: 4575-4585, doi:10.1210/en.2003-0268 [Abstract] [Full Text] [PDF]  

Vivian C. Calegari, Rosangela M. N. Bezerra, Márcio A. Torsoni, Adriana S. Torsoni, Kleber G. Franchini, Mário J. A. Saad, and Lício A. Velloso

Suppressor of Cytokine Signaling 3 Is Induced by Angiotensin II in Heart and Isolated Cardiomyocytes, and Participates in Desensitization
Endocrinology 2003 144: 4586-4596, doi:10.1210/en.2003-0046 [Abstract] [Full Text] [PDF]  

Marjorie A. Robbins, Lola Maksumova, Emma Pocock, and Janet K. Chantler

Nuclear Factor-B Translocation Mediates Double-Stranded Ribonucleic Acid-Induced NIT-1 ß-Cell Apoptosis and Up-Regulates Caspase-12 and Tumor Necrosis Factor Receptor-Associated Ligand (TRAIL)
Endocrinology 2003 144: 4616-4625, doi:10.1210/en.2003-0266 [Abstract] [Full Text] [PDF]  

NEUROENDOCRINOLOGY:

Helen I’Anson, Lois A. Sundling, Shannon M. Roland, and Sue Ritter

Immunotoxic Destruction of Distinct Catecholaminergic Neuron Populations Disrupts the Reproductive Response to Glucoprivation in Female Rats
Endocrinology 2003 144: 4325-4331, doi:10.1210/en.2003-0258 [Abstract] [Full Text] [PDF]  

Ennian Xiao, Linna Xia-Zhang, Nicolas R. Vulliémoz, Michel Ferin, and Sharon L. Wardlaw

Leptin Modulates Inflammatory Cytokine and Neuroendocrine Responses to Endotoxin in the Primate
Endocrinology 2003 144: 4350-4353, doi:10.1210/en.2003-0532 [Abstract] [Full Text] [PDF]  

Shannon D. Sullivan and Suzanne M. Moenter

Neurosteroids Alter -Aminobutyric Acid Postsynaptic Currents in Gonadotropin-Releasing Hormone Neurons: A Possible Mechanism for Direct Steroidal Control
Endocrinology 2003 144: 4366-4375, doi:10.1210/en.2003-0634 [Abstract] [Full Text] [PDF]  

Oscar Gómez and José Antonio Balsa

Autocrine/Paracrine Action of Pituitary Vasoactive Intestinal Peptide on Lactotroph Hyperplasia Induced by Estrogen
Endocrinology 2003 144: 4403-4409, doi:10.1210/en.2003-0261 [Abstract] [Full Text] [PDF]  

Linda Ste. Marie and Richard D. Palmiter

Norepinephrine and Epinephrine-Deficient Mice Are Hyperinsulinemic and Have Lower Blood Glucose
Endocrinology 2003 144: 4427-4432, doi:10.1210/en.2003-0561 [Abstract] [Full Text] [PDF]  

Hirotaka Sakamoto, Yukio Mezaki, Hanako Shikimi, Kazuyoshi Ukena, and Kazuyoshi Tsutsui

Dendritic Growth and Spine Formation in Response to Estrogen in the Developing Purkinje Cell
Endocrinology 2003 144: 4466-4477, doi:10.1210/en.2003-0307 [Abstract] [Full Text] [PDF]  

J. Falcón, L. Besseau, D. Fazzari, J. Attia, P. Gaildrat, M. Beauchaud, and G. Boeuf

Melatonin Modulates Secretion of Growth Hormone and Prolactin by Trout Pituitary Glands and Cells in Culture
Endocrinology 2003 144: 4648-4658, doi:10.1210/en.2003-0707 [Abstract] [Full Text] [PDF]  

PTH-CALCITONIN-VITAMIN D-BONE:

Liang Zhang, Xu Feng, and Jay M. McDonald

The Role of Calmodulin in the Regulation of Osteoclastogenesis
Endocrinology 2003 144: 4536-4543, doi:10.1210/en.2003-0147 [Abstract] [Full Text] [PDF]  

RECEPTORS:

Anna K. Greenwood, Paul C. Butler, Richard B. White, Ulrike DeMarco, David Pearce, and Russell D. Fernald

Multiple Corticosteroid Receptors in a Teleost Fish: Distinct Sequences, Expression Patterns, and Transcriptional Activities
Endocrinology 2003 144: 4226-4236, doi:10.1210/en.2003-0566 [Abstract] [Full Text] [PDF]  

Heather A. Harris, Leo M. Albert, Yelena Leathurby, Michael S. Malamas, Richard E. Mewshaw, Chris P. Miller, Yogendra P. Kharode, James Marzolf, Barry S. Komm, Richard C. Winneker, Donald E. Frail, Ruth A. Henderson, Yuan Zhu, and James C. Keith, Jr.

Evaluation of an Estrogen Receptor-ß Agonist in Animal Models of Human Disease
Endocrinology 2003 144: 4241-4249, doi:10.1210/en.2003-0550 [Abstract] [Full Text] [PDF]  

Brian D. Cohen, Jason T. Bariteau, Lori M. Magenis, and James A. Dias

Regulation of Follitropin Receptor Cell Surface Residency by the Ubiquitin-Proteasome Pathway
Endocrinology 2003 144: 4393-4402, doi:10.1210/en.2002-0063 [Abstract] [Full Text] [PDF]  

REPRODUCTION-DEVELOPMENT:

Alzira Rosa-e-Silva, Marco Aurelio Guimaraes, Vasantha Padmanabhan, and Hernán E. Lara

Prepubertal Administration of Estradiol Valerate Disrupts Cyclicity and Leads to Cystic Ovarian Morphology during Adult Life in the Rat: Role of Sympathetic Innervation
Endocrinology 2003 144: 4289-4297, doi:10.1210/en.2003-0146 [Abstract] [Full Text] [PDF]  

Fujun Liu, Darrell A. Austin, and Nicholas J. G. Webster

Gonadotropin-Releasing Hormone-Desensitized LßT2 Gonadotrope Cells Are Refractory to Acute Protein Kinase C, Cyclic AMP, and Calcium-Dependent Signaling
Endocrinology 2003 144: 4354-4365, doi:10.1210/en.2003-0204 [Abstract] [Full Text] [PDF]  

Scott A. Ochsner, Anthony J. Day, Marilyn S. Rugg, Richard M. Breyer, Richard H. Gomer, and Joanne S. Richards

Disrupted Function of Tumor Necrosis Factor--Stimulated Gene 6 Blocks Cumulus Cell-Oocyte Complex Expansion
Endocrinology 2003 144: 4376-4384, doi:10.1210/en.2003-0487 [Abstract] [Full Text] [PDF] [Supplemental movies]  

Rémy Burcelin, Bernard Thorens, Micheline Glauser, Rolf C. Gaillard, and François P. Pralong

Gonadotropin-Releasing Hormone Secretion from Hypothalamic Neurons: Stimulation by Insulin and Potentiation by Leptin
Endocrinology 2003 144: 4484-4491, doi:10.1210/en.2003-0457 [Abstract] [Full Text] [PDF]  

Kathleen H. Burns, Gabe E. Owens, Samuel C. Ogbonna, John H. Nilson, and Martin M. Matzuk

Expression Profiling Analyses of Gonadotropin Responses and Tumor Development in the Absence of Inhibins
Endocrinology 2003 144: 4492-4507, doi:10.1210/en.2003-0476 [Abstract] [Full Text] [PDF]  

Minnie Hsieh, Sabine M. Mulders, Robert R. Friis, Arun Dharmarajan, and JoAnne S. Richards

Expression and Localization of Secreted Frizzled-Related Protein-4 in the Rodent Ovary: Evidence for Selective Up-Regulation in Luteinized Granulosa Cells
Endocrinology 2003 144: 4597-4606, doi:10.1210/en.2003-0048 [Abstract] [Full Text] [PDF]  

Arzu Umar, Marja P. Ooms, Theo M. Luider, J. Anton Grootegoed, and Albert O. Brinkmann

Proteomic Profiling of Epididymis and Vas Deferens: Identification of Proteins Regulated during Rat Genital Tract Development
Endocrinology 2003 144: 4637-4647, doi:10.1210/en.2003-0404 [Abstract] [Full Text] [PDF]  

Arata Nakajima, Sumito Shimizu, Hideshige Moriya, and Masashi Yamazaki

Expression of Fibroblast Growth Factor Receptor-3 (FGFR3), Signal Transducer and Activator of Transcription-1, and Cyclin-Dependent Kinase Inhibitor p21 during Endochondral Ossification: Differential Role of FGFR3 in Skeletal Development and Fracture Repair
Endocrinology 2003 144: 4659-4668, doi:10.1210/en.2003-0158 [Abstract] [Full Text] [PDF]  

TRH-TSH-THYROID:

Emily C. Wasco, Elena Martinez, Katherine S. Grant, Emily A. St. Germain, Donald L. St. Germain, and Valerie Anne Galton

Determinants of Iodothyronine Deiodinase Activities in Rodent Uterus
Endocrinology 2003 144: 4253-4261, doi:10.1210/en.2003-0490 [Abstract] [Full Text] [PDF]  

Osamu Araki, Tadashi Morimura, Takayuki Ogiwara, Haruo Mizuma, Masatomo Mori, and Masami Murakami

Expression of Type 2 Iodothyronine Deiodinase in Corticotropin-Secreting Mouse Pituitary Tumor Cells Is Stimulated by Glucocorticoid and Corticotropin-Releasing Hormone
Endocrinology 2003 144: 4459-4465, doi:10.1210/en.2003-0419 [Abstract] [Full Text] [PDF]  

ANNOUNCEMENTS:

Biophysical Society 48th Annual Meeting February 14–18, 2004, Baltimore, MD
Endocrinology 2003 144: 4458 [Full Text] [PDF]  

RESEARCH RESOURCES:

Endocrine-Related Resources from the National Institutes of Health
Endocrinology 2003 144: 4670-4672 [Full Text] [PDF]  

National Hormone & Peptide Program (NHPP): New Recombinant Hormones, Hypothalamic Peptides, Natural Hormones, New Antisera, & Expanded Hormone Assay Services Available
Endocrinology 2003 144: 4673-4675 [Full Text] [PDF]  

THE ENDOCRINE SOCIETY:

The Endocrine Society and Pfizer, Inc. International Award for Excellence in Published Clinical Research in The Journal of Clinical Endocrinology & Metabolism
Endocrinology 2003 144: 4669 [Full Text] [PDF]  

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