NEWS & VIEWS:

Alessandro Bisello, Mara J. Horwitz, and Andrew F. Stewart

Parathyroid Hormone-Related Protein: An Essential Physiological Regulator of Adult Bone Mass
Endocrinology 2004 145: 3551-3553, doi:10.1210/en.2004-0509 [Full Text] [PDF]  

Vincent Poitout

ß-Cell Lipotoxicity: Burning Fat into Heat?
Endocrinology 2004 145: 3563-3565, doi:10.1210/en.2004-0479 [Full Text] [PDF]  

Adrian J. Dunn

Interleukin-6 Access to the Axis
Endocrinology 2004 145: 3578-3579, doi:10.1210/en.2004-0460 [Full Text] [PDF]  

Robert P. Millar and Adam J. Pawson

Outside-In and Inside-Out Signaling: The New Concept that Selectivity of Ligand Binding at the Gonadotropin-Releasing Hormone Receptor Is Modulated by the Intracellular Environment
Endocrinology 2004 145: 3590-3593, doi:10.1210/en.2004-0461 [Full Text] [PDF]  

BRIEF COMMUNICATIONS:

Tetsuo Shirakawa, Masato Mitome, Takashi Kikuiri, Wataru Nakamura, Shohei Oshima, Tomokazu Hasegawa, Masanobu Shindoh, and Haruhisa Oguchi

Immobilization Induces Acute Nitric Oxide Production in the Rat Hypothalamus: A Role of Ionotropic Glutamate Receptors in the Paraventricular Nucleus
Endocrinology 2004 145: 3603-3607, doi:10.1210/en.2004-0068 [Abstract] [Full Text] [PDF]  

Jean D. R. Tiong, Jennifer G. Pakiam, and Susan Wray

Gonadotropin Releasing Hormone-1 Expression in Incisors of Mice
Endocrinology 2004 145: 3608-3612, doi:10.1210/en.2004-0387 [Abstract] [Full Text] [PDF]  

Ishwar S. Parhar, Satoshi Ogawa, and Yasuo Sakuma

Laser-Captured Single Digoxigenin-Labeled Neurons of Gonadotropin-Releasing Hormone Types Reveal a Novel G Protein-Coupled Receptor (Gpr54) during Maturation in Cichlid Fish
Endocrinology 2004 145: 3613-3618, doi:10.1210/en.2004-0395 [Abstract] [Full Text] [PDF]  

CANCER:

Anne Marie Velasco, Kimberly A. Gillis, Yizheng Li, Eugene L. Brown, Tammy M. Sadler, Maria Achilleos, Lee M. Greenberger, Philip Frost, Wenlong Bai, and Yixian Zhang

Identification and Validation of Novel Androgen-Regulated Genes in Prostate Cancer
Endocrinology 2004 145: 3913-3924, doi:10.1210/en.2004-0311 [Abstract] [Full Text] [PDF] [Supplemental Data]  

Lian Fan, Carmen V. Pepicelli, Christian C. Dibble, Winnie Catbagan, Jodi L. Zarycki, Robert Laciak, Jerry Gipp, Aubie Shaw, Marilyn L. G. Lamm, Alejandro Munoz, Robert Lipinski, J. Brantley Thrasher, and Wade Bushman

Hedgehog Signaling Promotes Prostate Xenograft Tumor Growth
Endocrinology 2004 145: 3961-3970, doi:10.1210/en.2004-0079 [Abstract] [Full Text] [PDF]  

CRH-ACTH-POMC-ADRENAL:

Marni N. Silverman, Andrew H. Miller, Christine A. Biron, and Brad D. Pearce

Characterization of an Interleukin-6- and Adrenocorticotropin-Dependent, Immune-to-Adrenal Pathway during Viral Infection
Endocrinology 2004 145: 3580-3589, doi:10.1210/en.2003-1421 [Abstract] [Full Text] [PDF]  

Philipp Sterzer, G. Jan Wiegers, and Johannes M. H. M. Reul

Long-Term in Vivo Administration of Glucocorticoid Hormones Attenuates Their Capacity to Accelerate in Vitro Proliferation of Rat Splenic T Cells
Endocrinology 2004 145: 3630-3638, doi:10.1210/en.2003-1578 [Abstract] [Full Text] [PDF]  

Elaine Setiawan, Dawn Owen, Lucy McCabe, Alice Kostaki, Marcus H. Andrews, and Stephen G. Matthews

Glucocorticoids Do Not Alter Developmental Expression of Hippocampal or Pituitary Steroid Receptor Coactivator-1 and -2 in the Late Gestation Fetal Guinea Pig
Endocrinology 2004 145: 3796-3803, doi:10.1210/en.2003-1723 [Abstract] [Full Text] [PDF]  

Kelly L. Parham, Sevasti Zervou, Emmanouil Karteris, Rob D. Catalano, Robert W. Old, and Edward W. Hillhouse

Promoter Analysis of Human Corticotropin-Releasing Factor (CRF) Type 1 Receptor and Regulation by CRF and Urocortin
Endocrinology 2004 145: 3971-3983, doi:10.1210/en.2004-0194 [Abstract] [Full Text] [PDF]  

ENERGY BALANCE/OBESITY:

J. H. Peters, A. B. Karpiel, R. C. Ritter, and S. M. Simasko

Cooperative Activation of Cultured Vagal Afferent Neurons by Leptin and Cholecystokinin
Endocrinology 2004 145: 3652-3657, doi:10.1210/en.2004-0221 [Abstract] [Full Text] [PDF]  

Bryan R. Haugen, Dalan R. Jensen, Vibha Sharma, Leslie K. Pulawa, William R. Hays, Wojciech Krezel, Pierre Chambon, and Robert H. Eckel

Retinoid X Receptor -Deficient Mice Have Increased Skeletal Muscle Lipoprotein Lipase Activity and Less Weight Gain when Fed a High-Fat Diet
Endocrinology 2004 145: 3679-3685, doi:10.1210/en.2003-1401 [Abstract] [Full Text] [PDF]  

Norman Pecoraro, Faith Reyes, Francisca Gomez, Aditi Bhargava, and Mary F. Dallman

Chronic Stress Promotes Palatable Feeding, which Reduces Signs of Stress: Feedforward and Feedback Effects of Chronic Stress
Endocrinology 2004 145: 3754-3762, doi:10.1210/en.2004-0305 [Abstract] [Full Text] [PDF]  

Jean-Pierre Chanoine and Alfred C. K. Wong

Ghrelin Gene Expression Is Markedly Higher in Fetal Pancreas Compared with Fetal Stomach: Effect of Maternal Fasting
Endocrinology 2004 145: 3813-3820, doi:10.1210/en.2004-0053 [Abstract] [Full Text] [PDF]  

Sheng Bi, Karen A. Scott, Alan S. Kopin, and Timothy H. Moran

Differential Roles for Cholecystokinin A Receptors in Energy Balance in Rats and Mice
Endocrinology 2004 145: 3873-3880, doi:10.1210/en.2004-0284 [Abstract] [Full Text] [PDF]  

Eriika Savontaus, Tracy L. Breen, Andrea Kim, Lucy M. Yang, Streamson C. Chua, Jr., and Sharon L. Wardlaw

Metabolic Effects of Transgenic Melanocyte-Stimulating Hormone Overexpression in Lean and Obese Mice
Endocrinology 2004 145: 3881-3891, doi:10.1210/en.2004-0263 [Abstract] [Full Text] [PDF]  

Guo-Qing Chang, Olga Karatayev, Zoya Davydova, and Sarah F. Leibowitz

Circulating Triglycerides Impact on Orexigenic Peptides and Neuronal Activity in Hypothalamus
Endocrinology 2004 145: 3904-3912, doi:10.1210/en.2003-1582 [Abstract] [Full Text] [PDF]  

Henrike Sell, Joel P. Berger, Pierre Samson, Gino Castriota, Josée Lalonde, Yves Deshaies, and Denis Richard

Peroxisome Proliferator-Activated Receptor Agonism Increases the Capacity for Sympathetically Mediated Thermogenesis in Lean and ob/ob Mice
Endocrinology 2004 145: 3925-3934, doi:10.1210/en.2004-0321 [Abstract] [Full Text] [PDF]  

Hitomi Hama, Akihiko Saito, Tetsuro Takeda, Atsuhito Tanuma, Yuansheng Xie, Kiyoko Sato, Junichiro J. Kazama, and Fumitake Gejyo

Evidence Indicating that Renal Tubular Metabolism of Leptin Is Mediated by Megalin But Not by the Leptin Receptors
Endocrinology 2004 145: 3935-3940, doi:10.1210/en.2004-0074 [Abstract] [Full Text] [PDF]  

GENERAL ENDOCRINOLOGY:

Tracy A. Henriques, Jing Huang, Susan S. D’Souza, Alan Daugherty, and Lisa A. Cassis

Orchidectomy, But Not Ovariectomy, Regulates Angiotensin II-Induced Vascular Diseases in Apolipoprotein E-Deficient Mice
Endocrinology 2004 145: 3866-3872, doi:10.1210/en.2003-1615 [Abstract] [Full Text] [PDF]  

GRH-GH-SOMATOSTATIN:

Jun Kamegai, Hideki Tamura, Takako Shimizu, Shinya Ishii, Atsushi Tatsuguchi, Hitoshi Sugihara, Shinichi Oikawa, and Rhonda D. Kineman

The Role of Pituitary Ghrelin in Growth Hormone (GH) Secretion: GH-Releasing Hormone-Dependent Regulation of Pituitary Ghrelin Gene Expression and Peptide Content
Endocrinology 2004 145: 3731-3738, doi:10.1210/en.2003-1424 [Abstract] [Full Text] [PDF]  

GROWTH FACTORS-CYTOKINES-ONCOGENES:

Kyoko Maeshima, Akito Maeshima, Yoshiro Hayashi, Shoji Kishi, and Itaru Kojima

Crucial Role of Activin A in Tubulogenesis of Endothelial Cells Induced by Vascular Endothelial Growth Factor
Endocrinology 2004 145: 3739-3745, doi:10.1210/en.2004-0213 [Abstract] [Full Text] [PDF]  

Moran Rubinstein, Gila Idelman, Stephen R. Plymate, Goutham Narla, Scott L. Friedman, and Haim Werner

Transcriptional Activation of the Insulin-Like Growth Factor I Receptor Gene by the Kruppel-Like Factor 6 (KLF6) Tumor Suppressor Protein: Potential Interactions between KLF6 and p53
Endocrinology 2004 145: 3769-3777, doi:10.1210/en.2004-0173 [Abstract] [Full Text] [PDF]  

INSULIN-GLUCAGON-GI PEPTIDES-DIABETES:

Tokuyuki Yamashita, Kazuhiro Eto, Yukiko Okazaki, Shigeo Yamashita, Toshimasa Yamauchi, Nobuo Sekine, Ryozo Nagai, Mitsuhiko Noda, and Takashi Kadowaki

Role of Uncoupling Protein-2 Up-Regulation and Triglyceride Accumulation in Impaired Glucose-Stimulated Insulin Secretion in a ß-Cell Lipotoxicity Model Overexpressing Sterol Regulatory Element-Binding Protein-1c
Endocrinology 2004 145: 3566-3577, doi:10.1210/en.2003-1602 [Abstract] [Full Text] [PDF]  

Guangqun Xing, Tatsuo Shimosawa, Takehide Ogihara, Hiromitsu Matsui, Kanami Itakura, Xu Qingyou, Tomoichiro Asano, Katsuyuki Ando, and Toshiro Fujita

Angiotensin II-Induced Insulin Resistance Is Enhanced in Adrenomedullin-Deficient Mice
Endocrinology 2004 145: 3647-3651, doi:10.1210/en.2004-0027 [Abstract] [Full Text] [PDF]  

Malin Fex, Charlotta S. Olofsson, Ulrika Fransson, Karl Bacos, Håkan Lindvall, Maria Sörhede-Winzell, Patrik Rorsman, Cecilia Holm, and Hindrik Mulder

Hormone-Sensitive Lipase Deficiency in Mouse Islets Abolishes Neutral Cholesterol Ester Hydrolase Activity but Leaves Lipolysis, Acylglycerides, Fat Oxidation, and Insulin Secretion Intact
Endocrinology 2004 145: 3746-3753, doi:10.1210/en.2003-1673 [Abstract] [Full Text] [PDF]  

Yong Lian Zhu, Alexander Abdo, Joan F. Gesmonde, Kathleen C. Zawalich, Walter Zawalich, and Priscilla S. Dannies

Aggregation and Lack of Secretion of Most Newly Synthesized Proinsulin in Non-ß-Cell Lines
Endocrinology 2004 145: 3840-3849, doi:10.1210/en.2003-1512 [Abstract] [Full Text] [PDF]  

Li Wang, Catherine Coffinier, Melissa K. Thomas, Lionel Gresh, Ganiu Eddu, Tal Manor, Lynne L. Levitsky, Moshe Yaniv, and David B. Rhoads

Selective Deletion of the Hnf1ß (MODY5) Gene in ß-Cells Leads to Altered Gene Expression and Defective Insulin Release
Endocrinology 2004 145: 3941-3949, doi:10.1210/en.2004-0281 [Abstract] [Full Text] [PDF]  

NEUROENDOCRINOLOGY:

Alexander S. Kauffman and Emilie F. Rissman

A Critical Role for the Evolutionarily Conserved Gonadotropin-Releasing Hormone II: Mediation of Energy Status and Female Sexual Behavior
Endocrinology 2004 145: 3639-3646, doi:10.1210/en.2004-0148 [Abstract] [Full Text] [PDF]  

S. R. Ladyman and D. R. Grattan

Region-Specific Reduction in Leptin-Induced Phosphorylation of Signal Transducer and Activator of Transcription-3 (STAT3) in the Rat Hypothalamus Is Associated with Leptin Resistance during Pregnancy
Endocrinology 2004 145: 3704-3711, doi:10.1210/en.2004-0338 [Abstract] [Full Text] [PDF]  

Nancy K. Mueller, C. Mark Dolgas, and James P. Herman

Stressor-Selective Role of the Ventral Subiculum in Regulation of Neuroendocrine Stress Responses
Endocrinology 2004 145: 3763-3768, doi:10.1210/en.2004-0097 [Abstract] [Full Text] [PDF]  

Rachel E. Bowman, Neil J. MacLusky, Yessenia Sarmiento, Maya Frankfurt, Marisa Gordon, and Victoria N. Luine

Sexually Dimorphic Effects of Prenatal Stress on Cognition, Hormonal Responses, and Central Neurotransmitters
Endocrinology 2004 145: 3778-3787, doi:10.1210/en.2003-1759 [Abstract] [Full Text] [PDF]  

Victor V. Chaban, Alexander J. Lakhter, and Paul Micevych

A Membrane Estrogen Receptor Mediates Intracellular Calcium Release in Astrocytes
Endocrinology 2004 145: 3788-3795, doi:10.1210/en.2004-0149 [Abstract] [Full Text] [PDF]  

John C. Gill, Suzanne M. Moenter, and Pei-San Tsai

Developmental Regulation of Gonadotropin-Releasing Hormone Neurons by Fibroblast Growth Factor Signaling
Endocrinology 2004 145: 3830-3839, doi:10.1210/en.2004-0214 [Abstract] [Full Text] [PDF]  

PTH-CALCITONIN-VITAMIN D-BONE:

Dengshun Miao, Jiarong Li, Yingben Xue, Hanyi Su, Andrew C. Karaplis, and David Goltzman

Parathyroid Hormone-Related Peptide Is Required for Increased Trabecular Bone Volume in Parathyroid Hormone-Null Mice
Endocrinology 2004 145: 3554-3562, doi:10.1210/en.2003-1695 [Abstract] [Full Text] [PDF]  

Ibrahim C. Ozkurt, Flavia Q. Pirih, and Sotirios Tetradis

Parathyroid Hormone Induces E4bp4 Messenger Ribonucleic Acid Expression Primarily through Cyclic Adenosine 3',5'-Monophosphate Signaling in Osteoblasts
Endocrinology 2004 145: 3696-3703, doi:10.1210/en.2003-1436 [Abstract] [Full Text] [PDF]  

Baozhi Yuan, Yina Xing, Ron L. Horst, and Marc K. Drezner

Evidence for Abnormal Translational Regulation of Renal 25-Hydroxyvitamin D-1-Hydroxylase Activity in the Hyp-Mouse
Endocrinology 2004 145: 3804-3812, doi:10.1210/en.2004-0192 [Abstract] [Full Text] [PDF]  

RECEPTORS:

Christopher J. Caunt, James N. Hislop, Eamonn Kelly, Anne-Lise Matharu, Lisa D. Green, Kathleen R. Sedgley, Ann R. Finch, and Craig A. McArdle

Regulation of Gonadotropin-Releasing Hormone Receptors by Protein Kinase C: Inside Out Signalling and Evidence for Multiple Active Conformations
Endocrinology 2004 145: 3594-3602, doi:10.1210/en.2004-0092 [Abstract] [Full Text] [PDF]  

Shotaro Suzuki and Robert J. Handa

Regulation of Estrogen Receptor-ß Expression in the Female Rat Hypothalamus: Differential Effects of Dexamethasone and Estradiol
Endocrinology 2004 145: 3658-3670, doi:10.1210/en.2003-1688 [Abstract] [Full Text] [PDF]  

Mitsue Tetsuka, Yumiko Saito, Kensaku Imai, Hirofumi Doi, and Kei Maruyama

The Basic Residues in the Membrane-Proximal C-Terminal Tail of the Rat Melanin-Concentrating Hormone Receptor 1 Are Required for Receptor Function
Endocrinology 2004 145: 3712-3723, doi:10.1210/en.2003-1638 [Abstract] [Full Text] [PDF]  

Alfredo MartÍnez, Miguel Julián, Claudia Bregonzio, Luigi Notari, Terry W. Moody, and Frank Cuttitta

Identification of Vasoactive Nonpeptidic Positive and Negative Modulators of Adrenomedullin Using a Neutralizing Antibody-Based Screening Strategy
Endocrinology 2004 145: 3858-3865, doi:10.1210/en.2003-1251 [Abstract] [Full Text] [PDF]  

Kausik Ray, Sanchita P. Ghosh, and John K. Northup

The Role of Cysteines and Charged Amino Acids in Extracellular Loops of the Human Ca²⁺ Receptor in Cell Surface Expression and Receptor Activation Processes
Endocrinology 2004 145: 3892-3903, doi:10.1210/en.2003-1653 [Abstract] [Full Text] [PDF]  

RENIN-MINERALOCORTICOIDS-ANF-ADH:

Naveed Ahmad, Damian G. Romero, Elise P. Gomez-Sanchez, and Celso E. Gomez-Sanchez

Do Human Vascular Endothelial Cells Produce Aldosterone?
Endocrinology 2004 145: 3626-3629, doi:10.1210/en.2004-0081 [Abstract] [Full Text] [PDF]  

REPRODUCTION-DEVELOPMENT:

Motozumi Matsui, Barbara Sonntag, Seong Soo Hwang, Tara Byerly, Ariel Hourvitz, Eli Y. Adashi, Shunichi Shimasaki, and Gregory F. Erickson

Pregnancy-Associated Plasma Protein-A Production in Rat Granulosa Cells: Stimulation by Follicle-Stimulating Hormone and Inhibition by the Oocyte-Derived Bone Morphogenetic Protein-15
Endocrinology 2004 145: 3686-3695, doi:10.1210/en.2003-1642 [Abstract] [Full Text] [PDF]  

Deeksha Saxena, Rachid Safi, Lynda Little-Ihrig, and Anthony J. Zeleznik

Liver Receptor Homolog-1 Stimulates the Progesterone Biosynthetic Pathway during Follicle-Stimulating Hormone-Induced Granulosa Cell Differentiation
Endocrinology 2004 145: 3821-3829, doi:10.1210/en.2004-0423 [Abstract] [Full Text] [PDF]  

R. R. Gonzalez, B. R. Rueda, M. P. Ramos, R. D. Littell, S. Glasser, and P. C. Leavis

Leptin-Induced Increase in Leukemia Inhibitory Factor and Its Receptor by Human Endometrium Is Partially Mediated by Interleukin 1 Receptor Signaling
Endocrinology 2004 145: 3850-3857, doi:10.1210/en.2004-0383 [Abstract] [Full Text] [PDF]  

Kara L. Britt, Peter G. Stanton, Marie Misso, Evan R. Simpson, and Jock K. Findlay

The Effects of Estrogen on the Expression of Genes Underlying the Differentiation of Somatic Cells in the Murine Gonad
Endocrinology 2004 145: 3950-3960, doi:10.1210/en.2003-1628 [Abstract] [Full Text] [PDF]  

TRH-TSH-THYROID:

Balázs Gereben, Janusz Pachucki, Anna Kollár, Zsolt Liposits, and Csaba Fekete

Ontogenic Redistribution of Type 2 Deiodinase Messenger Ribonucleic Acid in the Brain of Chicken
Endocrinology 2004 145: 3619-3625, doi:10.1210/en.2004-0229 [Abstract] [Full Text] [PDF]  

Jin Guo, Pavel N. Pichurin, John C. Morris, Basil Rapoport, and Sandra M. McLachlan

"Naked" Deoxyribonucleic Acid Vaccination Induces Recognition of Diverse Thyroid Peroxidase T Cell Epitopes
Endocrinology 2004 145: 3671-3678, doi:10.1210/en.2004-0303 [Abstract] [Full Text] [PDF]  

Kimberly J. Land, Jennifer S. Moll, Mark H. Kaplan, and Gattadahalli S. Seetharamaiah

Signal Transducer and Activator of Transcription (Stat)-6-Dependent, But Not Stat4-Dependent, Immunity Is Required for the Development of Autoimmunity in Graves’ Hyperthyroidism
Endocrinology 2004 145: 3724-3730, doi:10.1210/en.2004-0352 [Abstract] [Full Text] [PDF]  

ANNOUNCEMENTS:

Erratum
Endocrinology 2004 145: 3593 [Full Text] [PDF]  

RESEARCH RESOURCES:

Annual Awards
Endocrinology 2004 145: 3984-3985 [Full Text] [PDF]  

THE ENDOCRINE SOCIETY 2004 ANNUAL AWARDS
Endocrinology 2004 145: 3986-3998 [Full Text] [PDF]  

Endocrine-Related Resources from the National Institutes of Health
Endocrinology 2004 145: 3999-4002 [Full Text] [PDF]  

National Hormone & Peptide Program (NHPP): New Recombinant Hormones, Hypothalamic Peptides, Natural Hormones, New Antisera, & Expanded Hormone Assay Services Available
Endocrinology 2004 145: 4003-4005 [Full Text] [PDF]  

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