NEWS & VIEWS:

Jeffrey D. Blaustein

Editorial: Embracing the Evolution of Endocrinology
Endocrinology 2008 149: 1-2, doi:10.1210/en.2007-1497 [Full Text] [PDF]  

Ho-Joon Lee and Jose Teixeira

Evidence of a Role for Androgens in Embryonic Stem Cell Function and Differentiation
Endocrinology 2008 149: 3-4, doi:10.1210/en.2007-1417 [Full Text] [PDF]  

BRIEF COMMUNICATIONS:

J. Mazella, S. Liang, and L. Tseng

Expression of Delta-Like Protein 4 in the Human Endometrium
Endocrinology 2008 149: 15-19; first published October 4 2007 as doi:10.1210/en.2007-0477 [Abstract] [Full Text] [PDF] [FREE Author Manuscript (PDF)]  

Mary C. Gieske, Hyun Joon Kim, Sandra J. Legan, Yongbum Koo, Andree Krust, Pierre Chambon, and CheMyong Ko

Pituitary Gonadotroph Estrogen Receptor- Is Necessary for Fertility in Females
Endocrinology 2008 149: 20-27; first published October 18 2007 as doi:10.1210/en.2007-1084 [Abstract] [Full Text] [PDF] [FREE Author Manuscript (PDF)]  

Monica Minnaard-Huiban, Judith M. A. Emmen, Luc Roumen, Ilona P. E. Beugels, Géraldine M. S. Cohuet, Helma van Essen, Eveline Ruijters, Koen Pieterse, Peter A. J. Hilbers, Harry C. J. Ottenheijm, Ralf Plate, Marcel E. de Gooyer, Jos F. M. Smits, and J. J. Rob Hermans

Fadrozole Reverses Cardiac Fibrosis in Spontaneously Hypertensive Heart Failure Rats: Discordant Enantioselectivity Versus Reduction of Plasma Aldosterone
Endocrinology 2008 149: 28-31; first published September 20 2007 as doi:10.1210/en.2007-0584 [Abstract] [Full Text] [PDF] [Supplemental Data] [FREE Author Manuscript (PDF)]  

CANCER:

Nicole M. Ramocki, Heather R. Wilkins, Scott T. Magness, James G. Simmons, Brooks P. Scull, Ginny H. Lee, Kirk K. McNaughton, and P. Kay Lund

Insulin Receptor Substrate-1 Deficiency Promotes Apoptosis in the Putative Intestinal Crypt Stem Cell Region, Limits Apc^min/+ Tumors, and Regulates Sox9
Endocrinology 2008 149: 261-267; first published October 4 2007 as doi:10.1210/en.2007-0869 [Abstract] [Full Text] [PDF] [FREE Author Manuscript (PDF)]  

CRH-ACTH-POMC-ADRENAL:

Avin S. Lalmansingh and Rosalie M. Uht

Estradiol Regulates Corticotropin-Releasing Hormone Gene (crh) Expression in a Rapid and Phasic Manner that Parallels Estrogen Receptor- and -β Recruitment to a 3',5'-Cyclic Adenosine 5'-Monophosphate Regulatory Region of the Proximal crh Promoter
Endocrinology 2008 149: 346-357; first published October 18 2007 as doi:10.1210/en.2007-0372 [Abstract] [Full Text] [PDF] [FREE Author Manuscript (PDF)]  

ENERGY BALANCE/OBESITY:

Loretta M. Flanagan-Cato, Steven J. Fluharty, Elena B. Weinreb, and Denise R. LaBelle

Food Restriction Alters Neuronal Morphology in the Hypothalamic Ventromedial Nucleus of Male Rats
Endocrinology 2008 149: 93-99; first published October 25 2007 as doi:10.1210/en.2007-0008 [Abstract] [Full Text] [PDF] [FREE Author Manuscript (PDF)]  

James L. Trevaskis, Emily A. Meyer, Jose E. Galgani, and Andrew A. Butler

Counterintuitive Effects of Double-Heterozygous Null Melanocortin-4 Receptor and Leptin Genes on Diet-Induced Obesity and Insulin Resistance in C57BL/6J Mice
Endocrinology 2008 149: 174-184; first published October 11 2007 as doi:10.1210/en.2007-0868 [Abstract] [Full Text] [PDF] [FREE Author Manuscript (PDF)]  

Ting Wang, Youxue Wang, Yasuhide Kontani, Yoshinori Kobayashi, Yuzo Sato, Nozomu Mori, and Hitoshi Yamashita

Evodiamine Improves Diet-Induced Obesity in a Uncoupling Protein-1-Independent Manner: Involvement of Antiadipogenic Mechanism and Extracellularly Regulated Kinase/Mitogen-Activated Protein Kinase Signaling
Endocrinology 2008 149: 358-366; first published September 20 2007 as doi:10.1210/en.2007-0467 [Abstract] [Full Text] [PDF] [FREE Author Manuscript (PDF)]  

GENERAL ENDOCRINOLOGY:

Sandra Cecconi, Annunziata Mauro, Giulia Capacchietti, Paolo Berardinelli, Nicola Bernabò, Anna Rita Di Vincenzo, Mauro Mattioli, and Barbara Barboni

Meiotic Maturation of Incompetent Prepubertal Sheep Oocytes Is Induced by Paracrine Factor(s) Released by Gonadotropin-Stimulated Oocyte-Cumulus Cell Complexes and Involves Mitogen-Activated Protein Kinase Activation
Endocrinology 2008 149: 100-107; first published September 20 2007 as doi:10.1210/en.2007-0874 [Abstract] [Full Text] [PDF] [FREE Author Manuscript (PDF)]  

Daryl O. Schwenke, Takeshi Tokudome, Mikiyasu Shirai, Hiroshi Hosoda, Takeshi Horio, Ichiro Kishimoto, and Kenji Kangawa

Exogenous Ghrelin Attenuates the Progression of Chronic Hypoxia-Induced Pulmonary Hypertension in Conscious Rats
Endocrinology 2008 149: 237-244; first published October 4 2007 as doi:10.1210/en.2007-0833 [Abstract] [Full Text] [PDF] [FREE Author Manuscript (PDF)]  

GENETICS/GENOMICS:

Veronique Douard, Xue-Lin Cui, Patricia Soteropoulos, and Ronaldo P. Ferraris

Dexamethasone Sensitizes the Neonatal Intestine to Fructose Induction of Intestinal Fructose Transporter (Slc2A5) Function
Endocrinology 2008 149: 409-423; first published October 18 2007 as doi:10.1210/en.2007-0906 [Abstract] [Full Text] [PDF] [Supplemental Data] [FREE Author Manuscript (PDF)]  

INSULIN-GLUCAGON-GI PEPTIDES-DIABETES:

Zhen Huang and Åke Sjöholm

Ethanol Acutely Stimulates Islet Blood Flow, Amplifies Insulin Secretion, and Induces Hypoglycemia via Nitric Oxide and Vagally Mediated Mechanisms
Endocrinology 2008 149: 232-236; first published October 4 2007 as doi:10.1210/en.2007-0632 [Abstract] [Full Text] [PDF] [FREE Author Manuscript (PDF)]  

Philip E. Dubé, Katherine J. Rowland, and Patricia L. Brubaker

Glucagon-Like Peptide-2 Activates β-Catenin Signaling in the Mouse Intestinal Crypt: Role of Insulin-Like Growth Factor-I
Endocrinology 2008 149: 291-301; first published September 20 2007 as doi:10.1210/en.2007-0561 [Abstract] [Full Text] [PDF] [FREE Author Manuscript (PDF)]  

Manuela Aragno, Raffaella Mastrocola, Giuseppe Alloatti, Ilenia Vercellinatto, Paola Bardini, Stefano Geuna, Maria Graziella Catalano, Oliviero Danni, and Giuseppe Boccuzzi

Oxidative Stress Triggers Cardiac Fibrosis in the Heart of Diabetic Rats
Endocrinology 2008 149: 380-388; first published September 27 2007 as doi:10.1210/en.2007-0877 [Abstract] [Full Text] [PDF] [Supplemental Data] [FREE Author Manuscript (PDF)]  

INTRACELLULAR SIGNALING:

Mitsuhiko Umahara, Shuichi Okada, Eijiro Yamada, Tsugumichi Saito, Kihachi Ohshima, Koshi Hashimoto, Masanobu Yamada, Hiroyuki Shimizu, Jeffrey E. Pessin, and Masatomo Mori

Tyrosine Phosphorylation of Munc18c Regulates Platelet-Derived Growth Factor-Stimulated Glucose Transporter 4 Translocation in 3T3L1 Adipocytes
Endocrinology 2008 149: 40-49; first published October 4 2007 as doi:10.1210/en.2006-1549 [Abstract] [Full Text] [PDF] [FREE Author Manuscript (PDF)]  

Dominic Devost, Marie-Eve Carrier, and Hans H. Zingg

Oxytocin-Induced Activation of Eukaryotic Elongation Factor 2 in Myometrial Cells Is Mediated by Protein Kinase C
Endocrinology 2008 149: 131-138; first published October 18 2007 as doi:10.1210/en.2007-0548 [Abstract] [Full Text] [PDF] [FREE Author Manuscript (PDF)]  

David A. MacIntyre, Elisa K. Tyson, Mark Read, Roger Smith, George Yeo, Kenneth Kwek, and Eng-Cheng Chan

Contraction in Human Myometrium Is Associated with Changes in Small Heat Shock Proteins
Endocrinology 2008 149: 245-252; first published October 4 2007 as doi:10.1210/en.2007-0662 [Abstract] [Full Text] [PDF] [FREE Author Manuscript (PDF)]  

Natalia Makeeva, Godfried M. Roomans, Jason W. Myers, and Nils Welsh

Transforming Growth Factor-β-Activated Protein Kinase 1-Binding Protein (TAB)-1, But Not TAB1β, Mediates Cytokine-Induced p38 Mitogen-Activated Protein Kinase Phosphorylation and Cell Death in Insulin-Producing Cells
Endocrinology 2008 149: 302-309; first published October 11 2007 as doi:10.1210/en.2007-0690 [Abstract] [Full Text] [PDF] [FREE Author Manuscript (PDF)]  

NEUROENDOCRINOLOGY:

Gabriela C. Wagner, Jonathan D. Johnston, Iain J. Clarke, Gerald A. Lincoln, and David G. Hazlerigg

Redefining the Limits of Day Length Responsiveness in a Seasonal Mammal
Endocrinology 2008 149: 32-39; first published September 27 2007 as doi:10.1210/en.2007-0658 [Abstract] [Full Text] [PDF] [FREE Author Manuscript (PDF)]  

Ana Alonso, María Moreno, Patricia Ordóñez, Rebeca Fernández, Cristina Pérez, Fernando Díaz, Ana Navarro, Jorge Tolivia, and Celestino González

Chronic Estradiol Treatment Improves Brain Homeostasis during Aging in Female Rats
Endocrinology 2008 149: 57-72; first published September 27 2007 as doi:10.1210/en.2007-0627 [Abstract] [Full Text] [PDF] [FREE Author Manuscript (PDF)]  

Scott R. Wersinger, Jennifer L. Temple, Heather K. Caldwell, and W. Scott Young, 3rd

Inactivation of the Oxytocin and the Vasopressin (Avp) 1b Receptor Genes, But Not the Avp 1a Receptor Gene, Differentially Impairs the Bruce Effect in Laboratory Mice (Mus musculus)
Endocrinology 2008 149: 116-121; first published October 18 2007 as doi:10.1210/en.2007-1056 [Abstract] [Full Text] [PDF] [FREE Author Manuscript (PDF)]  

D. J. Haisenleder, L. L. Burger, H. E. Walsh, J. Stevens, K. W. Aylor, M. A. Shupnik, and J. C. Marshall

Pulsatile Gonadotropin-Releasing Hormone Stimulation of Gonadotropin Subunit Transcription in Rat Pituitaries: Evidence for the Involvement of Jun N-Terminal Kinase But Not p38
Endocrinology 2008 149: 139-145; first published October 11 2007 as doi:10.1210/en.2007-1113 [Abstract] [Full Text] [PDF] [FREE Author Manuscript (PDF)]  

Rachel N. Danaher, Kerry M. Loomes, Bridget L. Leonard, Lynda Whiting, Debbie L. Hay, Lance Yi Xu, Edward W. Kraegen, Anthony R. J. Phillips, and Garth J. S. Cooper

Evidence that -Calcitonin Gene-Related Peptide Is a Neurohormone that Controls Systemic Lipid Availability and Utilization
Endocrinology 2008 149: 154-160; first published October 11 2007 as doi:10.1210/en.2007-0583 [Abstract] [Full Text] [PDF] [FREE Author Manuscript (PDF)]  

Jun Ming Wang, Lifei Liu, and Roberta Diaz Brinton

Estradiol-17β-Induced Human Neural Progenitor Cell Proliferation Is Mediated by an Estrogen Receptor β-Phosphorylated Extracellularly Regulated Kinase Pathway
Endocrinology 2008 149: 208-218; first published October 25 2007 as doi:10.1210/en.2007-1155 [Abstract] [Full Text] [PDF] [FREE Author Manuscript (PDF)]  

Takayoshi Ubuka, Stephanie Kim, Yu-chi Huang, Jessica Reid, Jennifer Jiang, Tomohiro Osugi, Vishwajit S. Chowdhury, Kazuyoshi Tsutsui, and George E. Bentley

Gonadotropin-Inhibitory Hormone Neurons Interact Directly with Gonadotropin-Releasing Hormone-I and -II Neurons in European Starling Brain
Endocrinology 2008 149: 268-278; first published September 27 2007 as doi:10.1210/en.2007-0983 [Abstract] [Full Text] [PDF] [Supplemental Data] [FREE Author Manuscript (PDF)]  

Stéphanie Constantin and Susan Wray

Gonadotropin-Releasing Hormone-1 Neuronal Activity Is Independent of Cyclic Nucleotide-Gated Channels
Endocrinology 2008 149: 279-290; first published October 4 2007 as doi:10.1210/en.2007-0955 [Abstract] [Full Text] [PDF] [FREE Author Manuscript (PDF)]  

Céline Callewaere, Brigitte Fernette, Danièle Raison, Patricia Mechighel, Arlette Burlet, André Calas, Patrick Kitabgi, Stéphane Mélik Parsadaniantz, and William Rostène

Cellular and Subcellular Evidence for Neuronal Interaction between the Chemokine Stromal Cell-Derived Factor-1/CXCL 12 and Vasopressin: Regulation in the Hypothalamo-Neurohypophysial System of the Brattleboro Rats
Endocrinology 2008 149: 310-319; first published September 27 2007 as doi:10.1210/en.2007-1097 [Abstract] [Full Text] [PDF] [FREE Author Manuscript (PDF)]  

Christian G. Ziegler, Flavie Sicard, Peter Lattke, Stefan R. Bornstein, Monika Ehrhart-Bornstein, and Alexander W. Krug

Dehydroepiandrosterone Induces a Neuroendocrine Phenotype in Nerve Growth Factor-Stimulated Chromaffin Pheochromocytoma PC12 Cells
Endocrinology 2008 149: 320-328; first published September 20 2007 as doi:10.1210/en.2007-0645 [Abstract] [Full Text] [PDF] [FREE Author Manuscript (PDF)]  

Chandramohan Wakade, Mohammad M. Khan, Liesl M. De Sevilla, Quan-Guang Zhang, Virendra B. Mahesh, and Darrell W. Brann

Tamoxifen Neuroprotection in Cerebral Ischemia Involves Attenuation of Kinase Activation and Superoxide Production and Potentiation of Mitochondrial Superoxide Dismutase
Endocrinology 2008 149: 367-379; first published September 27 2007 as doi:10.1210/en.2007-0899 [Abstract] [Full Text] [PDF] [FREE Author Manuscript (PDF)]  

Heather B. Patisaul, Anne E. Fortino, and Eva K. Polston

Sex Differences in Serotonergic But Not -Aminobutyric Acidergic (GABA) Projections to the Rat Ventromedial Nucleus of the Hypothalamus
Endocrinology 2008 149: 397-408; first published October 18 2007 as doi:10.1210/en.2007-0666 [Abstract] [Full Text] [PDF] [FREE Author Manuscript (PDF)]  

PTH-CALCITONIN-VIT D-BONE:

Carlo Galli, Lee A. Zella, Jackie A. Fretz, Qiang Fu, J. Wesley Pike, Robert S. Weinstein, Stavros C. Manolagas, and Charles A. O’Brien

Targeted Deletion of a Distant Transcriptional Enhancer of the Receptor Activator of Nuclear Factor-B Ligand Gene Reduces Bone Remodeling and Increases Bone Mass
Endocrinology 2008 149: 146-153; first published October 11 2007 as doi:10.1210/en.2007-0734 [Abstract] [Full Text] [PDF] [FREE Author Manuscript (PDF)]  

RECEPTORS:

Nina Renlund, Rafael Pieretti-Vanmarcke, Francis H. O’Neill, LiHua Zhang, Patricia K. Donahoe, and Jose Teixeira

c-Jun N-terminal Kinase Inhibitor II (SP600125) Activates Müllerian Inhibiting Substance Type II Receptor-Mediated Signal Transduction
Endocrinology 2008 149: 108-115; first published October 18 2007 as doi:10.1210/en.2007-0529 [Abstract] [Full Text] [PDF] [FREE Author Manuscript (PDF)]  

Beverly A. S. Reyes, Rita J. Valentino, and Elisabeth J. Van Bockstaele

Stress-Induced Intracellular Trafficking of Corticotropin-Releasing Factor Receptors in Rat Locus Coeruleus Neurons
Endocrinology 2008 149: 122-130; first published October 18 2007 as doi:10.1210/en.2007-0705 [Abstract] [Full Text] [PDF] [FREE Author Manuscript (PDF)]  

Yoshinao Katsu, Rie Ichikawa, Toshitaka Ikeuchi, Satomi Kohno, Louis J. Guillette, Jr., and Taisen Iguchi

Molecular Cloning and Characterization of Estrogen, Androgen, and Progesterone Nuclear Receptors from a Freshwater Turtle (Pseudemys nelsoni)
Endocrinology 2008 149: 161-173; first published October 4 2007 as doi:10.1210/en.2007-0938 [Abstract] [Full Text] [PDF] [FREE Author Manuscript (PDF)]  

Anastasios E. Damdimopoulos, Giannis Spyrou, and Jan-Åke Gustafsson

Ligands Differentially Modify the Nuclear Mobility of Estrogen Receptors and β
Endocrinology 2008 149: 339-345; first published September 20 2007 as doi:10.1210/en.2007-0198 [Abstract] [Full Text] [PDF] [Supplemental Data] [FREE Author Manuscript (PDF)]  

REPRODUCTION-DEVELOPMENT:

Denise R. Goldman-Johnson, David M. de Kretser, and John R. Morrison

Evidence that Androgens Regulate Early Developmental Events, Prior to Sexual Differentiation
Endocrinology 2008 149: 5-14; first published October 4 2007 as doi:10.1210/en.2007-1123 [Abstract] [Full Text] [PDF] [FREE Author Manuscript (PDF)]  

Manuel Ricu, Alfonso Paredes, Monika Greiner, Sergio R. Ojeda, and Hernan E. Lara

Functional Development of the Ovarian Noradrenergic Innervation
Endocrinology 2008 149: 50-56; first published October 18 2007 as doi:10.1210/en.2007-1204 [Abstract] [Full Text] [PDF] [FREE Author Manuscript (PDF)]  

Ximei Wu, Takuma Iguchi, Norio Itoh, Kousuke Okamoto, Tatsuya Takagi, Keiichi Tanaka, and Tsuyoshi Nakanishi

Ascorbic Acid Transported by Sodium-Dependent Vitamin C Transporter 2 Stimulates Steroidogenesis in Human Choriocarcinoma Cells
Endocrinology 2008 149: 73-83; first published September 27 2007 as doi:10.1210/en.2007-0262 [Abstract] [Full Text] [PDF] [FREE Author Manuscript (PDF)]  

Fiona H. Thomas, Helen Wilson, Audrey Silvestri, and Hamish M. Fraser

Thrombospondin-1 Expression Is Increased during Follicular Atresia in the Primate Ovary
Endocrinology 2008 149: 185-192; first published September 20 2007 as doi:10.1210/en.2007-0835 [Abstract] [Full Text] [PDF] [FREE Author Manuscript (PDF)]  

Jinchun Yan and Terry R. Brown

Cell Proliferation and Expression of Cell Cycle Regulatory Proteins that Control the G1/S Transition Are Age Dependent and Lobe Specific in the Brown Norway Rat Model of Prostatic Hyperplasia
Endocrinology 2008 149: 193-207; first published October 25 2007 as doi:10.1210/en.2007-1259 [Abstract] [Full Text] [PDF] [FREE Author Manuscript (PDF)]  

S. K. Banu, J. Lee, M. C. Satterfield, T. E. Spencer, F. W. Bazer, and J. A. Arosh

Molecular Cloning and Characterization of Prostaglandin (PG) Transporter in Ovine Endometrium: Role for Multiple Cell Signaling Pathways in Transport of PGF₂
Endocrinology 2008 149: 219-231; first published September 27 2007 as doi:10.1210/en.2007-1087 [Abstract] [Full Text] [PDF] [FREE Author Manuscript (PDF)]  

Noriyuki Takahashi, Masanori T. Itoh, and Bunpei Ishizuka

Human Chorionic Gonadotropin Induces Nestin Expression in Endothelial Cells of the Ovary via Vascular Endothelial Growth Factor Signaling
Endocrinology 2008 149: 253-260; first published October 4 2007 as doi:10.1210/en.2007-0774 [Abstract] [Full Text] [PDF] [FREE Author Manuscript (PDF)]  

Sarah J. Santos, Sandra Z. Haslam, and Susan E. Conrad

Estrogen and Progesterone are Critical Regulators of Stat5a Expression in the Mouse Mammary Gland
Endocrinology 2008 149: 329-338; first published September 20 2007 as doi:10.1210/en.2007-0594 [Abstract] [Full Text] [PDF] [FREE Author Manuscript (PDF)]  

TRH-TSH-THYROID:

Cesidio Giuliani, Yoshihiko Noguchi, Norikazu Harii, Giorgio Napolitano, Dante Tatone, Ines Bucci, Mauro Piantelli, Fabrizio Monaco, and Leonard D. Kohn

The Flavonoid Quercetin Regulates Growth and Gene Expression in Rat FRTL-5 Thyroid Cells
Endocrinology 2008 149: 84-92; first published October 25 2007 as doi:10.1210/en.2007-0618 [Abstract] [Full Text] [PDF] [FREE Author Manuscript (PDF)]  

Anna Solini, Sabina Cuccato, Davide Ferrari, Eleonora Santini, Sara Gulinelli, Maria Giulia Callegari, Angela Dardano, Pinuccia Faviana, Stephanie Madec, Francesco Di Virgilio, and Fabio Monzani

Increased P2X₇ Receptor Expression and Function in Thyroid Papillary Cancer: A New Potential Marker of the Disease?
Endocrinology 2008 149: 389-396; first published October 18 2007 as doi:10.1210/en.2007-1223 [Abstract] [Full Text] [PDF] [FREE Author Manuscript (PDF)]  

Sylvie Poncin, Anne-Catherine Gérard, Marie Boucquey, Maximin Senou, Pedro Buc Calderon, Bernard Knoops, Benoît Lengelé, Marie-Christine Many, and Ides M. Colin

Oxidative Stress in the Thyroid Gland: From Harmlessness to Hazard Depending on the Iodine Content
Endocrinology 2008 149: 424-433; first published September 20 2007 as doi:10.1210/en.2007-0951 [Abstract] [Full Text] [PDF] [FREE Author Manuscript (PDF)]  

ANNOUNCEMENTS:

Erratum
Endocrinology 2008 149: 366 [Full Text] [PDF]  

RESEARCH RESOURCES:

Endocrine-Related Resources from the National Institutes of Health
Endocrinology 2008 149: 434-437 [Full Text] [PDF]  

National Hormone & Peptide Program (NHPP): New Recombinant Hormones, Hypothalamic Peptides, Natural Hormones, New Antisera, & Expanded Hormone Assay Services Available
Endocrinology 2008 149: 438-440 [Full Text] [PDF]  

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