NEWS AND VIEWS:

Jeffrey D. Blaustein

Editorial: The Word for This Year Is Change
Endocrinology 2009 150: 1-2, doi:10.1210/en.2008-1562 [Full Text] [PDF]  

Stephen A. Huang

Deiodination and Cellular Proliferation: Parallels between Development, Differentiation, Tumorigenesis, and Now Regeneration
Endocrinology 2009 150: 3-4, doi:10.1210/en.2008-1460 [Full Text] [PDF]  

CALCIUM REGULATING HORMONES:

Aymen I. Idris, Iain R. Greig, Euphemie Bassonga-Landao, Stuart H. Ralston, and Rob J. van 't Hof

Identification of Novel Biphenyl Carboxylic Acid Derivatives as Novel Antiresorptive Agents that Do Not Impair Parathyroid Hormone-Induced Bone Formation
Endocrinology 2009 150: 5-13, doi:10.1210/en.2008-0998 [Abstract] [Full Text] [PDF]  
The biphenyl-carboxylate ABD350 inhibits osteoclast formation in vitro and in vivo and, unlike the bisphosphonate Alendronate, does not inhibit the bone anabolic effects of PTH.

CANCER - ONCOGENES:

Brian D. Adams, Kevin P. Claffey, and Bruce A. White

Argonaute-2 Expression Is Regulated by Epidermal Growth Factor Receptor and Mitogen-Activated Protein Kinase Signaling and Correlates with a Transformed Phenotype in Breast Cancer Cells
Endocrinology 2009 150: 14-23, doi:10.1210/en.2008-0984 [Abstract] [Full Text] [PDF] [Supplemental Data]  
Argonaute-2 is elevated in ER- breast cancer cells due to epidermal growth factor receptor/MAPK signaling, and overexpression of this gene induces a more transformed phenotype in ER+ MCF-7 cells.

DIABETES - INSULIN - GLUCAGON - GASTROINTESTINAL:

Li Li, LaWanda H. Thompson, Ling Zhao, and Joseph L. Messina

Tissue-Specific Difference in the Molecular Mechanisms for the Development of Acute Insulin Resistance after Injury
Endocrinology 2009 150: 24-32, doi:10.1210/en.2008-0742 [Abstract] [Full Text] [PDF]  
Glucocorticoids play a major role in the development of acute insulin resistance following hemorrhage in skeletal muscle, but not in the liver.

Magalie A. Ravier, Myriam Nenquin, Takashi Miki, Susumu Seino, and Jean-Claude Henquin

Glucose Controls Cytosolic Ca²⁺ and Insulin Secretion in Mouse Islets Lacking Adenosine Triphosphate-Sensitive K⁺ Channels Owing to a Knockout of the Pore-Forming Subunit Kir6.2
Endocrinology 2009 150: 33-45, doi:10.1210/en.2008-0617 [Abstract] [Full Text] [PDF]  
Glucose can stimulate insulin secretion from beta cells by increasing Ca2+ influx, cytosolic Ca2+ concentration, and Ca2+ action independently of ATP-sensitive K channels.

Judith A. Herlein, Brian D. Fink, Yunxia O'Malley, and William I. Sivitz

Superoxide and Respiratory Coupling in Mitochondria of Insulin-Deficient Diabetic Rats
Endocrinology 2009 150: 46-55, doi:10.1210/en.2008-0404 [Abstract] [Full Text] [PDF] [Supplemental Data]  
Mitochondria of streptozotocin-diabetic rats do not generate excess superoxide, manifest decreased or unchanged respiratory coupling, and show adaptation to antecedent in vivo oxidative stress.

Hélène Duez, Angela C. Smith, C. Xiao, Adria Giacca, Linda Szeto, Daniel J. Drucker, and Gary F. Lewis

Acute Dipeptidyl Peptidase-4 Inhibition Rapidly Enhances Insulin-Mediated Suppression of Endogenous Glucose Production in Mice
Endocrinology 2009 150: 56-62, doi:10.1210/en.2008-1137 [Abstract] [Full Text] [PDF] [Supplemental Data]  
Acute intravenous administration of des-F-sitagliptin, but not exendin 4, enhances insulin-mediated suppression of endogenous glucose production, but not glucose disposal in mice.

Aramati B. M. Reddy, Kota V. Ramana, Sanjay Srivastava, Aruni Bhatnagar, and Satish K. Srivastava

Aldose Reductase Regulates High Glucose-Induced Ectodomain Shedding of Tumor Necrosis Factor (TNF)- via Protein Kinase C- and TNF- Converting Enzyme in Vascular Smooth Muscle Cells
Endocrinology 2009 150: 63-74, doi:10.1210/en.2008-0677 [Abstract] [Full Text] [PDF]  
In adrenocortical cells high versus low levels of steroidogenic factor 1 (SF-1) differentially regulates the expression of aldosterone synthase and aldosterone production.

L. Matthews, A. Berry, M. Tersigni, F. D'Acquisto, A. Ianaro, and D. Ray

Thiazolidinediones Are Partial Agonists for the Glucocorticoid Receptor
Endocrinology 2009 150: 75-86, doi:10.1210/en.2008-0196 [Abstract] [Full Text] [PDF]  
Rosiglitazone, ciglitazone, and pioglitazone are partial glucocorticoid receptor (GR) agonists, affecting GR phosphorylation, subcellular trafficking, co-modulator recruitment, and transcription regulatory function independently of peroxisome proliferator-activated receptorã.

Marie-Josée Boucher, Mélanie Simoneau, and Helena Edlund

The Homeodomain-Interacting Protein Kinase 2 Regulates Insulin Promoter Factor-1/Pancreatic Duodenal Homeobox-1 Transcriptional Activity
Endocrinology 2009 150: 87-97, doi:10.1210/en.2007-0865 [Abstract] [Full Text] [PDF]  
Homeodomain-interacting protein kinase 2 phosphorylates the C-terminal portion of IPF1/PDX1 as well as positively regulating IPF1/PDX1 transcriptional activity.

ENERGY BALANCE - OBESITY:

Levente Deli, Gábor Wittmann, Imre Kalló, Ronald M. Lechan, Masahiko Watanabe, Zsolt Liposits, and Csaba Fekete

Type 1 Cannabinoid Receptor-Containing Axons Innervate Hypophysiotropic Thyrotropin-Releasing Hormone-Synthesizing Neurons
Endocrinology 2009 150: 98-103, doi:10.1210/en.2008-0330 [Abstract] [Full Text] [PDF]  
Type 1 cannabinoid receptor-containing axons establish both symmetric- and asymmetric-type synapses with hypophysiotropic TSH-releasing hormone neurons, suggesting that the endocannabinoid system is involved in the regulation of the hypothalamic–pituitary–thyroid axis.

Zhenwei Gong, Cheng Huang, Xiaoyan Sheng, Yuebo Zhang, Qunyi Li, Ming-Wei Wang, Linling Peng, and Ying Qin Zang

The Role of Tanshinone IIA in the Treatment of Obesity through Peroxisome Proliferator-Activated Receptor Antagonism
Endocrinology 2009 150: 104-113, doi:10.1210/en.2008-0322 [Abstract] [Full Text] [PDF]  
Tanshinone IIA (Tan), an herbal compound, which reduces body weight and lowers blood lipids, is a natural antagonist of peroxisome proliferator-activated receptor .

Karen Tan, Irina D. Pogozheva, Giles S. H. Yeo, Dirk Hadaschik, Julia M. Keogh, Carrie Haskell-Leuvano, Stephen O'Rahilly, Henry I. Mosberg, and I. Sadaf Farooqi

Functional Characterization and Structural Modeling of Obesity Associated Mutations in the Melanocortin 4 Receptor
Endocrinology 2009 150: 114-125, doi:10.1210/en.2008-0721 [Abstract] [Full Text] [PDF] [Supplemental Data]  
Among obesity-associated melanocortin-4 receptor mutations, four transmembrane domains and peripheral helix 8 are necessary for coupling of ligand binding to signaling.

Sung-E Choi, Sung-Mi Lee, Youn-Jung Lee, Ling-Ji Li, Soo-Jin Lee, Ji-Hyun Lee, Youngsoo Kim, Hee-Sook Jun, Kwan-Woo Lee, and Yup Kang

Protective Role of Autophagy in Palmitate-Induced INS-1 β-Cell Death
Endocrinology 2009 150: 126-134, doi:10.1210/en.2008-0483 [Abstract] [Full Text] [PDF] [Supplemental Data]  
Autophagy is activated in palmitate-treated insulinoma-1 beta cells, and the induction of autophagy plays a protective role in palmitate-induced beta cell death.

Glenn C. Rowe, Cheol Soo Choi, Lynn Neff, William C. Horne, Gerald I. Shulman, and Roland Baron

Increased Energy Expenditure and Insulin Sensitivity in the High Bone Mass FosB Transgenic Mice
Endocrinology 2009 150: 135-143, doi:10.1210/en.2008-0678 [Abstract] [Full Text] [PDF]  
Overexpression of FosB under the control of the enolase 2 promoter increases bone mass and energy expenditure by increasing fatty-acid oxidation within muscle, reducing adiposity.

M. L. Bouxsein, M. J. Devlin, V. Glatt, H. Dhillon, D. D. Pierroz, and S. L. Ferrari

Mice Lacking β-Adrenergic Receptors Have Increased Bone Mass but Are Not Protected from Deleterious Skeletal Effects of Ovariectomy
Endocrinology 2009 150: 144-152, doi:10.1210/en.2008-0843 [Abstract] [Full Text] [PDF]  
Mice lacking ß-adrenergic receptors have increased body weight, bone mineral density, and bone turnover versus controls, but are not protected from bone loss due to deficiency of estrogens..

Andreas Stengel, Miriam Goebel, Mulugeta Million, Mary P. Stenzel-Poore, Peter Kobelt, Hubert Mönnikes, Yvette Taché, and Lixin Wang

Corticotropin-Releasing Factor-Overexpressing Mice Exhibit Reduced Neuronal Activation in the Arcuate Nucleus and Food Intake in Response to Fasting
Endocrinology 2009 150: 153-160, doi:10.1210/en.2008-0723 [Abstract] [Full Text] [PDF]  
Sustained over-production of brain corticotrophin-releasing factor interferes with fasting-activated neuronal activation in the arcuate nucleus and results in reduction of food intake dissociated from gastric emptying.

Maayan Barnea, Zecharia Madar, and Oren Froy

High-Fat Diet Delays and Fasting Advances the Circadian Expression of Adiponectin Signaling Components in Mouse Liver
Endocrinology 2009 150: 161-168, doi:10.1210/en.2008-0944 [Abstract] [Full Text] [PDF] [Supplemental Data]  
Adiponectin signaling pathway components exhibit circadian rhythmicity under low-fat diet. Fasting and high-fat diet alter this circadian expression, leading to phase advance and delay, respectively.

Elena Bonzón-Kulichenko, Dominik Schwudke, Nilda Gallardo, Eduardo Moltó, Teresa Fernández-Agulló, Andrej Shevchenko, and Antonio Andrés

Central Leptin Regulates Total Ceramide Content and Sterol Regulatory Element Binding Protein-1C Proteolytic Maturation in Rat White Adipose Tissue
Endocrinology 2009 150: 169-178, doi:10.1210/en.2008-0505 [Abstract] [Full Text] [PDF] [Supplemental Data]  
Central leptin decreases total ceramide levels and prevents sterol regulatory element binding protein (SREBP-1C) proteolytic maturation in white adipose tissue, and probably, in this way, contributes to improve the overall insulin sensitivity.

Jennifer L. Miles, Korinna Huber, Nichola M. Thompson, Michael Davison, and Bernhard H. Breier

Moderate Daily Exercise Activates Metabolic Flexibility to Prevent Prenatally Induced Obesity
Endocrinology 2009 150: 179-186, doi:10.1210/en.2008-1035 [Abstract] [Full Text] [PDF]  
Obesity induced by prenatal undernutrition is effectively prevented by moderate daily exercise through the activation of distinct pathways of hepatic metabolic flexibility.

GENERAL ENDOCRINOLOGY:

Pulak R. Manna, Matthew T. Dyson, Youngah Jo, and Douglas M. Stocco

Role of Dosage-Sensitive Sex Reversal, Adrenal Hypoplasia Congenita, Critical Region on the X Chromosome, Gene 1 in Protein Kinase A- and Protein Kinase C-Mediated Regulation of the Steroidogenic Acute Regulatory Protein Expression in Mouse Leydig Tumor Cells: Mechanism of Action
Endocrinology 2009 150: 187-199, doi:10.1210/en.2008-0368 [Abstract] [Full Text] [PDF] [Supplemental Data]  
The characterization of protein kinase A- and protein kinase C-mediated steroidogenic acute regulatory (StAR) expression and steroidogenesis suggests that the orphan nuclear receptor DAX-1 is an important regulator of the steroidogenic response in Leydig cells.

Yohann Mérot, François Ferrière, Luc Gailhouste, Guillaume Huet, Frédéric Percevault, Christian Saligaut, and Gilles Flouriot

Different Outcomes of Unliganded and Liganded Estrogen Receptor- on Neurite Outgrowth in PC12 Cells
Endocrinology 2009 150: 200-211, doi:10.1210/en.2008-0449 [Abstract] [Full Text] [PDF]  
In the absence of its ligand, ER partially inhibits the nerve growth factor-induced neurite outgrowth of PC12 cells, whereas, once liganded, it enhances differentiation.

James P. Stice, Jason P. Eiserich, and A. A. Knowlton

Role of Aging Versus the Loss of Estrogens in the Reduction in Vascular Function in Female Rats
Endocrinology 2009 150: 212-219, doi:10.1210/en.2008-0640 [Abstract] [Full Text] [PDF]  
The combination of loss of estradiol and aging leads to increased constriction (phenylephrine) and decreased relaxation with nitric oxide. Reduced soluble guanylyl cyclase mediates these changes.

Maxim D. Seferovic, Rashad Ali, Hiroyasu Kamei, Suya Liu, Javad M. Khosravi, Steven Nazarian, Victor K. M. Han, Cunming Duan, and Madhulika B. Gupta

Hypoxia and Leucine Deprivation Induce Human Insulin-Like Growth Factor Binding Protein-1 Hyperphosphorylation and Increase Its Biological Activity
Endocrinology 2009 150: 220-231, doi:10.1210/en.2008-0657 [Abstract] [Full Text] [PDF]  
The use of HepG2 cells demonstrates that IGF binding protein-1 hyper-phosphorylation may be a novel mechanism of fetal adaptive response to hypoxia and under-nutrition.

Andreas Stengel, Miriam Goebel, Iskandar Yakubov, Lixin Wang, Derrick Witcher, Tamer Coskun, Yvette Taché, George Sachs, and Nils W. G. Lambrecht

Identification and Characterization of Nesfatin-1 Immunoreactivity in Endocrine Cell Types of the Rat Gastric Oxyntic Mucosa
Endocrinology 2009 150: 232-238, doi:10.1210/en.2008-0747 [Abstract] [Full Text] [PDF]  
Nesfatin-1/nucleobindin 2 is co-expressed in gastric ghrelin-containing X/A-like cells, suggesting the release of orexigenic and anorexigenic peptides from the same endocrine cells regulating food intake.

Gérard Alonso, Evelyne Galibert, Véra Boulay, Anne Guillou, Alexandra Jean, Valérie Compan, and Gilles Guillon

Sustained Elevated Levels of Circulating Vasopressin Selectively Stimulate the Proliferation of Kidney Tubular Cells via the Activation of V₂ Receptors
Endocrinology 2009 150: 239-250, doi:10.1210/en.2008-0068 [Abstract] [Full Text] [PDF] [Supplemental Data]  
Elevated levels of circulating vasopressin selectively stimulate the proliferation of kidney tubular cells via the activation of V2 receptors, thus showing the potential implication in polycystic kidney diseases.

Ming Chen, Iawen Hsu, Andrew Wolfe, Sally Radovick, KuoHsiang Huang, Shengqiang Yu, Chawnshang Chang, Edward M. Messing, and Shuyuan Yeh

Defects of Prostate Development and Reproductive System in the Estrogen Receptor- Null Male Mice
Endocrinology 2009 150: 251-259, doi:10.1210/en.2008-0044 [Abstract] [Full Text] [PDF] [Supplemental Data]  
Newly generated ACTB-Cre/Estrogen receptor alpha knockout (ER-/-) male mice show that ER acts through a paracrine mechanism to regulate prostatic branching morphogenesis and is involved in the proliferation and differentiation of prostatic stoma.

GLUCOCORTICOIDS - CRH - ACTH - ADRENAL:

Nicole J. Westphal, Ryan T. Evans, and Audrey F. Seasholtz

Novel Expression of Type 1 Corticotropin-Releasing Hormone Receptor in Multiple Endocrine Cell Types in the Murine Anterior Pituitary
Endocrinology 2009 150: 260-267, doi:10.1210/en.2008-0630 [Abstract] [Full Text] [PDF]  
Corticotropin-releasing hormone receptor 1 mRNA is detected in multiple mouse anterior pituitary cell types, including corticotropes, lactotropes, and gonadotropes, in a sexually dimorphic pattern.

J. E. Gibbs, S. Beesley, J. Plumb, D. Singh, S. Farrow, D. W. Ray, and A. S. I. Loudon

Circadian Timing in the Lung; A Specific Role for Bronchiolar Epithelial Cells
Endocrinology 2009 150: 268-276, doi:10.1210/en.2008-0638 [Abstract] [Full Text] [PDF]  
There is a glucocorticoid-sensitive circadian clock within the lung. The bronchial epithelial Clara cells play a critical role in pulmonary circadian timing.

GROWTH FACTORS - CYTOKINES:

Cheng-Gang Zou, Xiu-Zhen Cao, Yue-Shui Zhao, Shun-Yu Gao, Shu-De Li, Xian-Yong Liu, Yan Zhang, and Ke-Qin Zhang

The Molecular Mechanism of Endoplasmic Reticulum Stress-Induced Apoptosis in PC-12 Neuronal Cells: The Protective Effect of Insulin-Like Growth Factor I
Endocrinology 2009 150: 277-285, doi:10.1210/en.2008-0794 [Abstract] [Full Text] [PDF] [Supplemental Data]  
Endoplasmic reticulum (ER) stress causes neuronal apoptosis by inducing the expression of tribbles-related protein 3 and PUMA. IGF-1 prevents neuronal apoptosis against ER stress through phosphatidylinositide 3-kinase/Akt and p38 mitogen-activated protein kinase pathways.

Adel Amirouche, Anne-Cécile Durieux, Sébastien Banzet, Nathalie Koulmann, Régis Bonnefoy, Catherine Mouret, Xavier Bigard, André Peinnequin, and Damien Freyssenet

Down-Regulation of Akt/Mammalian Target of Rapamycin Signaling Pathway in Response to Myostatin Overexpression in Skeletal Muscle
Endocrinology 2009 150: 286-294, doi:10.1210/en.2008-0959 [Abstract] [Full Text] [PDF]  
Myostatin down-regulates Akt/mammalian target of rapamycin (mTOR) signaling pathway uncovering a novel role for myostatin in protein metabolism and more specifically in the regulation of translation in skeletal muscle.

Masaood Ganaiem, Mahmoud AbuElhija, Eitan Lunenfeld, Nataly Cherniy, Neomi Weisze, Sarit Bar-Sheshet Itach, Haiem Breitbart, Ronnie Apte, and Mahmoud Huleihel

Effect of Interleukin-1 Receptor Antagonist Gene Deletion on Male Mouse Fertility
Endocrinology 2009 150: 295-303, doi:10.1210/en.2008-0848 [Abstract] [Full Text] [PDF]  
IL-1 receptor antagonist knockout mice indicate the involvement of IL-1 in sperm physiology; high levels of IL-1 affect its morphology and fertilization ability.

Julieta L. Maymó, Antonio Pérez Pérez, Víctor Sánchez-Margalet, José L. Dueñas, Juan Carlos Calvo, and Cecilia L. Varone

Up-Regulation of Placental Leptin by Human Chorionic Gonadotropin
Endocrinology 2009 150: 304-313, doi:10.1210/en.2008-0522 [Abstract] [Full Text] [PDF]  
Human chorionic gonadotropin induces leptin expression in trophoblastic BeWo cells and placental explants analyzed by western-blot and reporter gene strategy. This effect involves the MAPK signal transduction pathway.

GROWTH HORMONE - SOMATOSTATIN - GRH:

Laurent Kappeler, Carlos De Magalhaes Filho, Patricia Leneuve, Jie Xu, Nadège Brunel, Christos Chatziantoniou, Yves Le Bouc, and Martin Holzenberger

Early Postnatal Nutrition Determines Somatotropic Function in Mice
Endocrinology 2009 150: 314-323, doi:10.1210/en.2008-0981 [Abstract] [Full Text] [PDF] [Supplemental Data]  
Early postnatal nutrition determines adult activity of the GH axis through an early modulation of hypothalamic GHRH stimulation, probably via hormones like leptin or IGF-I.

NEUROENDOCRINOLOGY:

Angela M. Wong, Irina Rozovsky, Jason M. Arimoto, Yizhou Du, Min Wei, Todd E. Morgan, and Caleb E. Finch

Progesterone Influence on Neurite Outgrowth Involves Microglia
Endocrinology 2009 150: 324-332, doi:10.1210/en.2008-0988 [Abstract] [Full Text] [PDF]  
Brain glia mediate progesterone–estradiol cross-talk in neuronal sprouting after axotomy in rat models.

Jing Xu, Melissa A. Kirigiti, Michael A. Cowley, Kevin L. Grove, and M. Susan Smith

Suppression of Basal Spontaneous Gonadotropin-Releasing Hormone Neuronal Activity during Lactation: Role of Inhibitory Effects of Neuropeptide Y
Endocrinology 2009 150: 333-340, doi:10.1210/en.2008-0962 [Abstract] [Full Text] [PDF]  
Neuropeptide Y (NPY) directly hyperpolarizes GnRH neurons via postsynaptic NPY Y5 receptor. Increased inhibitory NPY tone during lactation is an important component of the suppression of GnRH neuronal activity.

Amy E. Oakley, Kellie M. Breen, Iain J. Clarke, Fred J. Karsch, Elizabeth R. Wagenmaker, and Alan J. Tilbrook

Cortisol Reduces Gonadotropin-Releasing Hormone Pulse Frequency in Follicular Phase Ewes: Influence of Ovarian Steroids
Endocrinology 2009 150: 341-349, doi:10.1210/en.2008-0587 [Abstract] [Full Text] [PDF]  
A sustained stress-like level of cortisol reduces GnRH pulse frequency in the follicular phase and appears to require the presence of ovarian steroids.

REPRODUCTION - DEVELOPMENT:

Yasushi Hirota, Yutaka Osuga, Akiko Hasegawa, Ako Kodama, Toshiki Tajima, Kahori Hamasaki, Kaori Koga, Osamu Yoshino, Tetsuya Hirata, Miyuki Harada, Yuri Takemura, Tetsu Yano, Osamu Tsutsumi, and Yuji Taketani

Interleukin (IL)-1β Stimulates Migration and Survival of First-Trimester Villous Cytotrophoblast Cells through Endometrial Epithelial Cell-Derived IL-8
Endocrinology 2009 150: 350-356, doi:10.1210/en.2008-0264 [Abstract] [Full Text] [PDF]  
Interleukin (IL)-1β induces secretion of IL-8 from endometrial epithelial cells, and the secreted IL-8 stimulates migration and survival of first trimester villous cytotrophoblast cells.

Ángel García-López, Jan Bogerd, Joke C. M. Granneman, Wytske van Dijk, John M. Trant, Geir Lasse Taranger, and Rüdiger W. Schulz

Leydig Cells Express Follicle-Stimulating Hormone Receptors in African Catfish
Endocrinology 2009 150: 357-365, doi:10.1210/en.2008-0447 [Abstract] [Full Text] [PDF] [Supplemental Data]  
In search of a mechanistic basis for the strong steroidogenic activity of fish FSH, we demonstrate FSH receptor expression by Leydig cells in catfish.

Solange Miguel-Queralt, Caroline Underhill, Robert H. Devlin, and Geoffrey L. Hammond

Characterization and Measurement of the Plasma - and β-Sex Hormone-Binding Globulin Paralogs in Salmon
Endocrinology 2009 150: 366-375, doi:10.1210/en.2008-0964 [Abstract] [Full Text] [PDF]  
An assay for salmonid sex hormone-binding globulin paralogs (SHBG- and SHBG-β) has been developed, and gills and/or muscle are the main sources of plasma SHBG-β.

Jill K. Hiney, Vinod K. Srivastava, Michelle D. Pine, and W. Les Dees

Insulin-Like Growth Factor-I Activates KiSS-1 Gene Expression in the Brain of the Prepubertal Female Rat
Endocrinology 2009 150: 376-384, doi:10.1210/en.2008-0954 [Abstract] [Full Text] [PDF]  
IGF-1 is an early activator of the KiSS-1 gene at the time of female puberty.

Amanda Jones, Jiyun Chen, Dong Jin Hwang, Duane D. Miller, and James T. Dalton

Preclinical Characterization of a (S)-N-(4-Cyano-3-Trifluoromethyl-Phenyl)-3-(3-Fluoro, 4-Chlorophenoxy)-2-Hydroxy-2-Methyl-Propanamide: A Selective Androgen Receptor Modulator for Hormonal Male Contraception
Endocrinology 2009 150: 385-395, doi:10.1210/en.2008-0674 [Abstract] [Full Text] [PDF]  
An aryl-propionamide selective androgen receptor modulator (S-23) is an effective and reversible agent for hormonal male contraception in rats.

Ho Lin, Mei-Chih Chen, and Chien-Te Ku

Cyclin-Dependent Kinase 5 Regulates Steroidogenic Acute Regulatory Protein and Androgen Production in Mouse Leydig Cells
Endocrinology 2009 150: 396-403, doi:10.1210/en.2008-0496 [Abstract] [Full Text] [PDF] [Supplemental Data]  
The physiological function of cyclin-dependent kinase 5 (Cdk5) in mouse Leydig cells is to regulate androgen production through stabilizing the steroiodogenic acute regulatory (StAR) protein.

Olga Dakhova, Diana O'Day, Noe Kinet, Nur Yucer, Mary Wiese, Gunapala Shetty, and Patricia Ducy

Dickkopf-Like1 Regulates Postpubertal Spermatocyte Apoptosis and Testosterone Production
Endocrinology 2009 150: 404-412, doi:10.1210/en.2008-0673 [Abstract] [Full Text] [PDF] [Supplemental Data]  
Dickkopf-like 1 negatively regulates adult testis biology by promoting spermatocyte apoptosis via Fas ligand activation and by limiting testosterone synthesis in Leydig cells.

Eyal Klipper, Ehud Tatz, Tatiana Kisliouk, Israel Vlodavsky, Uzi Moallem, Dieter Schams, Yaniv Lavon, David Wolfenson, and Rina Meidan

Induction of Heparanase in Bovine Granulosa Cells by Luteinizing Hormone: Possible Role during the Ovulatory Process
Endocrinology 2009 150: 413-421, doi:10.1210/en.2008-0697 [Abstract] [Full Text] [PDF]  
Granulosa-derived heparanase is a novel member of the luteinizing hormone-induced extracellular matrix-degrading enzymes contributing to follicular rupture and ovulation.

Ewa Liszewska, Pierrette Reinaud, Emmanuelle Billon-Denis, Olivier Dubois, Philippe Robin, and Gilles Charpigny

Lysophosphatidic Acid Signaling during Embryo Development in Sheep: Involvement in Prostaglandin Synthesis
Endocrinology 2009 150: 422-434, doi:10.1210/en.2008-0749 [Abstract] [Full Text] [PDF]  
Lysophosphatidic acid (LPA) receptor 1 (R1) and LPAR3 mediate signaling of lysophosphatidic acid produced by autotaxin and induce prostaglandin biosynthesis and cytoskeleton changes in ovine trophectoderm cells at implantation time.

Nune Markosyan and Diane M. Duffy

Prostaglandin E2 Acts via Multiple Receptors to Regulate Plasminogen-Dependent Proteolysis in the Primate Periovulatory Follicle
Endocrinology 2009 150: 435-444, doi:10.1210/en.2008-0591 [Abstract] [Full Text] [PDF]  
Different prostaglandin E2 receptors increase granulosa cell expression of tissue type plasminogen activator (PA) and PA inhibitor type 1, so receptor-selective agonists may be useful to promote or prevent proteolysis needed for ovulation.

Leon J. S. Brokken, Annika Adamsson, Jorma Paranko, and Jorma Toppari

Antiandrogen Exposure in Utero Disrupts Expression of Desert Hedgehog and Insulin-Like Factor 3 in the Developing Fetal Rat Testis
Endocrinology 2009 150: 445-451, doi:10.1210/en.2008-0230 [Abstract] [Full Text] [PDF]  
Antiandrogenic exposure of rat fetuses in utero affects genes that are involved in sexual differentiation of the testis and suppresses sexual maturation.

Virginia D. Winn, Matthew Gormley, Agnes C. Paquet, Kasper Kjaer-Sorensen, Anita Kramer, Kristen K. Rumer, Ronit Haimov-Kochman, Ru-Fang Yeh, Michael T. Overgaard, Ajit Varki, Claus Oxvig, and Susan J. Fisher

Severe Preeclampsia-Related Changes in Gene Expression at the Maternal-Fetal Interface Include Sialic Acid-Binding Immunoglobulin-Like Lectin-6 and Pappalysin-2
Endocrinology 2009 150: 452-462, doi:10.1210/en.2008-0990 [Abstract] [Full Text] [PDF] [Supplemental Data]  
Gene expression analysis of placental basal plates from severe preeclamptic pregnancies and controls revealed differential expression of 55 genes, including Siglec-6 and pappalysin-2.

Brigid Orr, O. Cathal Grace, Griet Vanpoucke, George R. Ashley, and Axel A. Thomson

A Role for Notch Signaling in Stromal Survival and Differentiation during Prostate Development
Endocrinology 2009 150: 463-472, doi:10.1210/en.2008-0383 [Abstract] [Full Text] [PDF] [Supplemental Data]  
Studies on the expression of delta-like 1 homolog (Dlk1) and Notch 2 in prostatic mesenchyme shows that inhibition of notch signaling leads to defects in mesenchymal differentiation.

Christopher Tubbs and Peter Thomas

Progestin Signaling through an Olfactory G Protein and Membrane Progestin Receptor- in Atlantic Croaker Sperm: Potential Role in Induction of Sperm Hypermotility
Endocrinology 2009 150: 473-484, doi:10.1210/en.2008-0512 [Abstract] [Full Text] [PDF]  
Progestin activation of an olfactory G protein pathway, likely through membrane progestin receptor alpha, is associated with induction of hypermotility in Atlantic croaker sperm.

TECHNICAL COMMUNICATIONS:

Narayanan Krishnaswamy, Pierre Chapdelaine, Jacques P. Tremblay, and Michel A. Fortier

Development and Characterization of a Simian Virus 40 Immortalized Bovine Endometrial Stromal Cell Line
Endocrinology 2009 150: 485-491, doi:10.1210/en.2008-0744 [Abstract] [Full Text] [PDF]  
Interferon-T stimulates prostaglandin E2 production, and expression of cyclooxygenase 2 and signal transducer and activator of transcription 1 through two distinct signaling pathways in immortalized bovine endometrial stromal cells.

THYROID - TRH - TSH:

Cindy Y. Chen, Hiroaki Kimura, Melissa A. Landek-Salgado, Judith Hagedorn, Miho Kimura, Koichi Suzuki, William Westra, Noel R. Rose, and Patrizio Caturegli

Regenerative Potentials of the Murine Thyroid in Experimental Autoimmune Thyroiditis: Role of CD24
Endocrinology 2009 150: 492-499, doi:10.1210/en.2008-0639 [Abstract] [Full Text] [PDF] [Supplemental Data]  
The murine thyroid is capable of restoring its architecture after an insult that almost completely destroys it.

Juan Pablo Nicola, María Laura Vélez, Ariel Maximiliano Lucero, Laura Fozzatti, Claudia Gabriela Pellizas, and Ana María Masini-Repiso

Functional Toll-Like Receptor 4 Conferring Lipopolysaccharide Responsiveness Is Expressed in Thyroid Cells
Endocrinology 2009 150: 500-508, doi:10.1210/en.2008-0345 [Abstract] [Full Text] [PDF] [Supplemental Data]  
Thyroid cells recognize and respond to lipopolysaccharide through Toll-like receptor 4 supporting a role of the endotoxin as a potential modifier of thyroid function.

Roberta Botta, Simonetta Lisi, Aldo Pinchera, Franco Giorgi, Claudio Marcocci, Anna Rita Taddei, Anna Maria Fausto, Nunzia Bernardini, Chiara Ippolito, Letizia Mattii, Luca Persani, Tiziana de Filippis, Davide Calebiro, Peder Madsen, Claus Munck Petersen, and Michele Marinò

Sortilin Is a Putative Postendocytic Receptor of Thyroglobulin
Endocrinology 2009 150: 509-518, doi:10.1210/en.2008-0953 [Abstract] [Full Text] [PDF]  
Evidence for a novel pathway of thyroglobulin trafficking and for a possible novel function of sortilin in the thyroid gland is discussed.

Syed A. Morshed, Rauf Latif, and Terry F. Davies

Characterization of Thyrotropin Receptor Antibody-Induced Signaling Cascades
Endocrinology 2009 150: 519-529, doi:10.1210/en.2008-0878 [Abstract] [Full Text] [PDF]  
Antibodies to the TSH receptor produce unique signaling imprints which differ from its ligand, indicating that these antibodies have variable effects on thyroid cell biology.

Chaminda N. Walpita, Alexander D. Crawford, Els D. R. Janssens, Serge Van der Geyten, and Veerle M. Darras

Type 2 Iodothyronine Deiodinase Is Essential for Thyroid Hormone-Dependent Embryonic Development and Pigmentation in Zebrafish
Endocrinology 2009 150: 530-539, doi:10.1210/en.2008-0457 [Abstract] [Full Text] [PDF]  
Knockdown of type 2 iodothyronine deiodinase negatively affects development and pigmentation in zebrafish embryos, showing the importance of intracellular thyroid hormone activation in early development.

Monique H. A. Kester, Mathilda J. M. Toussaint, Carine A. Punt, Ramadan Matondo, Anne M. Aarnio, Veerle M. Darras, Marjanne E. Everts, Alain de Bruin, and Theo J. Visser

Large Induction of Type III Deiodinase Expression After Partial Hepatectomy in the Regenerating Mouse and Rat Liver
Endocrinology 2009 150: 540-545, doi:10.1210/en.2008-0344 [Abstract] [Full Text] [PDF]  
A large increase of type III deiodinase expression in the regenerating liver suggests a role for this enzyme in cellular proliferation.

Norma A. S. Almeida, Aline Cordeiro, Danielle S. Machado, Luana L. Souza, Tânia M. Ortiga-Carvalho, Antonio C. Campos-de-Carvalho, Fredric E. Wondisford, and Carmen C. Pazos-Moura

Connexin40 Messenger Ribonucleic Acid Is Positively Regulated by Thyroid Hormone (TH) Acting in Cardiac Atria via the TH Receptor
Endocrinology 2009 150: 546-554, doi:10.1210/en.2008-0451 [Abstract] [Full Text] [PDF]  
Cardiac-specific expression of a mutant thyroid hormone receptor unable to bind thyroid hormone profoundly reduces atrial connexin 40 expression in association with prolonged atrial conduction.

TRANSLATIONAL HIGHLIGHTS FROM JCEM:

Erkut Attar, Hideki Tokunaga, Gonca Imir, M. Bertan Yilmaz, David Redwine, Michael Putman, Bilgin Gurates, Rukset Attar, Nobuo Yaegashi, Dale B. Hales, and Serdar E. Bulun

Prostaglandin E₂ via Steroidogenic Factor-1 Coordinately Regulates Transcription of Steroidogenic Genes Necessary for Estrogen Synthesis in Endometriosis
Endocrinology 2009 150: 555, doi:10.1210/jc.2008-0821 [Full Text] [PDF]  

Richard Kremer, Patricia P. Campbell, Timothy Reinhardt, and Vicente Gilsanz

Vitamin D Status and its Relationship to Body Fat, Final Height, and Peak Bone Mass in Young Women
Endocrinology 2009 150: 555 [Full Text] [PDF]  

ANNOUNCEMENTS AND RESOURCES:

Erratum
Endocrinology 2009 150: 556 [Full Text] [PDF]  

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