CALCIUM-REGULATING HORMONES:

I. Delhon, S. Gutzwiller, F. Morvan, S. Rangwala, L. Wyder, G. Evans, A. Studer, M. Kneissel, and B. Fournier

Absence of Estrogen Receptor-Related- Increases Osteoblastic Differentiation and Cancellous Bone Mineral Density
Endocrinology 2009 150: 4463-4472 , doi:10.1210/en.2009-0121 [Abstract] [Full Text] [PDF] [Supplemental Data]  
ERR silencing in human mesenchymal stem cells increases osteoblastic differentiation while inhibiting adipogenesis; ERR-deficient mice display a moderate increase in cancellous bone mass.

CANCER-ONCOGENES:

Naeem Amiry, Xiangjun Kong, Nethaji Muniraj, Nagarajan Kannan, Prudence M. Grandison, Juan Lin, Yulu Yang, Cécile M. Vouyovitch, Sahra Borges, Jo K. Perry, Hichem C. Mertani, Tao Zhu, Dongxu Liu, and Peter E. Lobie

Trefoil Factor-1 (TFF1) Enhances Oncogenicity of Mammary Carcinoma Cells
Endocrinology 2009 150: 4473-4483 , doi:10.1210/en.2009-0066 [Abstract] [Full Text] [PDF] [Supplemental Data]  
Secretion of trefoil factor-1 by mammary carcinoma cells promotes tumor progression; therapeutic targeting of TFF1 should provide a novel approach for treatment of mammary carcinoma.

Olga Sukocheva, Lijun Wang, Emily Verrier, Mathew A. Vadas, and Pu Xia

Restoring Endocrine Response in Breast Cancer Cells by Inhibition of the Sphingosine Kinase-1 Signaling Pathway
Endocrinology 2009 150: 4484-4492 , doi:10.1210/en.2009-0391 [Abstract] [Full Text] [PDF]  
Sphingosine kinase-1 confers tamoxifen resistance to human breast cancer cells.

DIABETES-INSULIN-GLUCAGON-GASTROINTESTINAL:

Thierry Sulpice, Bénédicte Prunet-Marcassus, Cécile Molveaux, Patrice D. Cani, Pierre-Alain Vitte, Pierre Graber, Michel Dreano, and Rémy Burcelin

An Adiponectin-Like Molecule with Antidiabetic Properties
Endocrinology 2009 150: 4493-4501 , doi:10.1210/en.2008-1768 [Abstract] [Full Text] [PDF]  
rgAd110-244, a recombinant globular domain of adiponectin, represents an efficient therapeutic strategy for the treatment of insulin resistant syndromes.

Jonathan German, Francis Kim, Gary J. Schwartz, Peter J. Havel, Christopher J. Rhodes, Michael W. Schwartz, and Gregory J. Morton

Hypothalamic Leptin Signaling Regulates Hepatic Insulin Sensitivity via a Neurocircuit Involving the Vagus Nerve
Endocrinology 2009 150: 4502-4511 , doi:10.1210/en.2009-0445 [Abstract] [Full Text] [PDF]  
Hypothalamic leptin signaling improves hepatic insulin sensitivity via vagal input to the liver.

Salma Begum, Wei Chen, Kevan C. Herold, and Virginia E. Papaioannou

Remission of Type 1 Diabetes after Anti-CD3 Antibody Treatment and Transplantation of Embryonic Pancreatic Precursors
Endocrinology 2009 150: 4512-4520 , doi:10.1210/en.2009-0287 [Abstract] [Full Text] [PDF] [Supplemental Data]  
Long-term remission of type 1 diabetes can be attained by controlling autoimmunity and supplying pancreatic progenitor cells by transplantation of fetal tissue housing the pancreas.

Sabine Rütti, Jan A. Ehses, Rahel A. Sibler, Richard Prazak, Lucia Rohrer, Spiros Georgopoulos, Daniel T. Meier, Nadja Niclauss, Thierry Berney, Marc Y. Donath, and Arnold von Eckardstein

Low- and High-Density Lipoproteins Modulate Function, Apoptosis, and Proliferation of Primary Human and Murine Pancreatic β-Cells
Endocrinology 2009 150: 4521-4530 , doi:10.1210/en.2009-0252 [Abstract] [Full Text] [PDF]  
HDL protects human and mouse β-cells from apoptosis, and LDL decreases human and mouse β-cell proliferation and function.

Lisa D. Norquay, Katharine E. D'Aquino, Lynn M. Opare-Addo, Alexandra Kuznetsova, Michael Haas, Jeffrey A. Bluestone, and Morris F. White

Insulin Receptor Substrate-2 in β-Cells Decreases Diabetes in Nonobese Diabetic Mice
Endocrinology 2009 150: 4531-4540 , doi:10.1210/en.2009-0395 [Abstract] [Full Text] [PDF]  
Increasing expression of Irs2 in the pancreas attenuates the progression of β-celdestruction, promotes β-cell mitogenesis, and reduces diabetes incidence in NOD^Irs2-mice.

ANNOUNCEMENTS AND RESOURCES:

The Power of Programming: International Conference on Development Origins of Health and Disease May 6–8, 2010, Munich, Germany
Endocrinology 2009 150: 4501 [Full Text] [PDF]  

ENERGY BALANCE-OBESITY:

Eneida C. Villanueva, Heike Münzberg, Daniela Cota, Rebecca L. Leshan, Keely Kopp, Ryoko Ishida-Takahashi, Justin C. Jones, Diane C. Fingar, Randy J. Seeley, and Martin G. Myers, Jr.

Complex Regulation of Mammalian Target of Rapamycin Complex 1 in the Basomedial Hypothalamus by Leptin and Nutritional Status
Endocrinology 2009 150: 4541-4551 , doi:10.1210/en.2009-0642 [Abstract] [Full Text] [PDF] [Supplemental Data]  
The regulation of mTORC1 in the basomedial hypothalamus varies by cell and stimulus type, rather than responding uniformly to nutritional and hormonal perturbations.

Weiqin Chen, Vijay K. Yechoor, Benny Hung-Junn Chang, Ming V. Li, Keith L. March, and Lawrence Chan

The Human Lipodystrophy Gene Product Berardinelli-Seip Congenital Lipodystrophy 2/Seipin Plays a Key Role in Adipocyte Differentiation
Endocrinology 2009 150: 4552-4561 , doi:10.1210/en.2009-0236 [Abstract] [Full Text] [PDF] [Supplemental Data]  
Mutations in Seipin underlie Berardinelli-Seip congenital generalized lipodystrophy-2; Seipin is required for adipocyte differentiation, working upstream or at the level of PPAR during adipogenesis.

Susana Sangiao-Alvarellos, María J. Vázquez, Luis Varela, Rubén Nogueiras, Asish K. Saha, Fernando Cordido, Miguel López, and Carlos Diéguez

Central Ghrelin Regulates Peripheral Lipid Metabolism in a Growth Hormone-Independent Fashion
Endocrinology 2009 150: 4562-4574 , doi:10.1210/en.2009-0482 [Abstract] [Full Text] [PDF] [Supplemental Data]  
Central ghrelin favors lipid storage in a GH-independent mode in fat and liver, induces changes in lipid oxidation in a GH-independent fashion in fat, and in a GH-dependent fashion in liver.

Helen Imrie, Afroze Abbas, Hema Viswambharan, Adil Rajwani, Richard M. Cubbon, Matthew Gage, Matthew Kahn, Vivienne A. Ezzat, Edward R. Duncan, Peter J. Grant, Ramzi Ajjan, Stephen B. Wheatcroft, and Mark T. Kearney

Vascular Insulin-Like Growth Factor-I Resistance and Diet-Induced Obesity
Endocrinology 2009 150: 4575-4582 , doi:10.1210/en.2008-1641 [Abstract] [Full Text] [PDF]  
Dietary-induced obesity leads to whole body and vascular IGF-1 resistance.

GENERAL ENDOCRINOLOGY:

Junling Chen, Beum-Soo An, Linan Cheng, Geoffrey L. Hammond, and Peter C. K. Leung

Gonadotropin-Releasing Hormone-Mediated Phosphorylation of Estrogen Receptor- Contributes to fosB Expression in Mouse Gonadotrophs
Endocrinology 2009 150: 4583-4593 , doi:10.1210/en.2009-0455 [Abstract] [Full Text] [PDF] [Supplemental Data]  
GnRH-I and GnRH-II induce phosphorylation of ER in mouse gonadotrophs, which contributes to fosB gene expression.

Irwin I. Park, Qiang Zhang, Victoria Liu, James M. Kozlowski, Ju Zhang, and Chung Lee

17β-Estradiol at Low Concentrations Acts through Distinct Pathways in Normal Versus Benign Prostatic Hyperplasia-Derived Prostate Stromal Cells
Endocrinology 2009 150: 4594-4605 , doi:10.1210/en.2008-1591 [Abstract] [Full Text] [PDF] [Supplemental Data]  
The mechanism for the development of benign prostatic hyperplasia based on 17β-estradiol signaling properties, which may lead to the development of more effective therapies for this disorder, is described.

GLUCOCORTICOIDS-CRH-ACTH-ADRENAL:

Christina Chandras, Yassemi Koutmani, Efi Kokkotou, Charalabos Pothoulakis, and Katia P. Karalis

Activation of Phosphatidylinositol 3-Kinase/Protein Kinase B by Corticotropin-Releasing Factor in Human Monocytes
Endocrinology 2009 150: 4606-4614 , doi:10.1210/en.2008-1810 [Abstract] [Full Text] [PDF]  
Corticotropin-releasing factor may protect human monocytes from apoptosis and up-regulate proinflammatory cytokines.

Neeltje G. van Gemert, Diana M. M. Carvalho, Henk Karst, Siem van der Laan, Mingxu Zhang, Onno C. Meijer, Johannes W. Hell, and Marian Joëls

Dissociation between Rat Hippocampal CA1 and Dentate Gyrus Cells in Their Response to Corticosterone: Effects on Calcium Channel Protein and Current
Endocrinology 2009 150: 4615-4624 , doi:10.1210/en.2009-0525 [Abstract] [Full Text] [PDF]  
Corticosterone affects hippocampal calcium current and calcium channel protein levels in a region-dependent manner.

GROWTH FACTORS-CYTOKINES:

Yuhei Hotta, Hirotoshi Nakamura, Morichika Konishi, Yusuke Murata, Hiroyuki Takagi, Shigenobu Matsumura, Kazuo Inoue, Tohru Fushiki, and Nobuyuki Itoh

Fibroblast Growth Factor 21 Regulates Lipolysis in White Adipose Tissue But Is Not Required for Ketogenesis and Triglyceride Clearance in Liver
Endocrinology 2009 150: 4625-4633 , doi:10.1210/en.2009-0119 [Abstract] [Full Text] [PDF]  
Fgf21 regulates lipolysis in adipocytes in response to the metabolic state but is not required for ketogenesis and triglyceride clearance in the liver.

Cun Li, Natalia E. Schlabritz-Loutsevitch, Gene B. Hubbard, Victor Han, Karen Nygard, Laura A. Cox, Thomas J. McDonald, and Peter W. Nathanielsz

Effects of Maternal Global Nutrient Restriction on Fetal Baboon Hepatic Insulin-Like Growth Factor System Genes and Gene Products
Endocrinology 2009 150: 4634-4642 , doi:10.1210/en.2008-1648 [Abstract] [Full Text] [PDF] [Supplemental Data]  
Moderate global reduction in maternal nutrient intake decreases activity of the IGF system in the fetal baboon liver, providing a mechanism to explain altered growth and differentiation in the placenta and key fetal organs.

GROWTH HORMONE-SOMATOSTATIN-GRH:

Francisca Rodríguez-Pacheco, Rafael Vázquez-Martínez, Antonio J. Martínez-Fuentes, Marina R. Pulido, Manuel D. Gahete, Hubert Vaudry, Francisco Gracia-Navarro, Carlos Diéguez, Justo P. Castaño, and Maria M. Malagón

Resistin Regulates Pituitary Somatotrope Cell Function through the Activation of Multiple Signaling Pathways
Endocrinology 2009 150: 4643-4652 , doi:10.1210/en.2009-0116 [Abstract] [Full Text] [PDF] [Supplemental Data]  
Resistin increases GH release and free cytosolic Ca²⁺ concentration in rat somatotropes.

NEUROENDOCRINOLOGY:

Claudia Unfried, Nariman Ansari, Shinobu Yasuo, Horst-Werner Korf, and Charlotte von Gall

Impact of Melatonin and Molecular Clockwork Components on the Expression of Thyrotropin β-Chain (Tshb) and the Tsh Receptor in the Mouse Pars Tuberalis
Endocrinology 2009 150: 4653-4662 , doi:10.1210/en.2009-0609 [Abstract] [Full Text] [PDF] [Supplemental Data]  
Direct evidence is shown for a dual control of Tshb expression in the pars tuberalis by melatonin and the molecular clockwork, supporting the hypothesis of a complex TSH-dependent interaction between the pars tuberalis and the mediobasal hypothalamus regulating seasonal changes in reproduction.

Sushma R. Singh, Stanley M. Hileman, John M. Connors, Christina J. McManus, Lique M. Coolen, Michael N. Lehman, and Robert L. Goodman

Estradiol Negative Feedback Regulation by Glutamatergic Afferents to A15 Dopaminergic Neurons: Variation with Season
Endocrinology 2009 150: 4663-4671 , doi:10.1210/en.2009-0432 [Abstract] [Full Text] [PDF]  
Glutamatergic afferents to A15 dopaminergic neurons mediate estradiol negative feedback in anestrus and decrease in breeding season ewes in parallel with inhibitory actions of estradiol.

REPRODUCTION-DEVELOPMENT:

Shabana Jaffer, Oksana Shynlova, and Stephen Lye

Mammalian Target of Rapamycin Is Activated in Association with Myometrial Proliferation during Pregnancy
Endocrinology 2009 150: 4672-4680 , doi:10.1210/en.2009-0419 [Abstract] [Full Text] [PDF] [Supplemental Data]  
PI3K/mTOR signaling pathway is activated in myometrium of pregnant rats during proliferative phase of gestation and of ovariectomized rats after treatment with estradiol.

Aparna Mahakali Zama and Mehmet Uzumcu

Fetal and Neonatal Exposure to the Endocrine Disruptor Methoxychlor Causes Epigenetic Alterations in Adult Ovarian Genes
Endocrinology 2009 150: 4681-4691 , doi:10.1210/en.2009-0499 [Abstract] [Full Text] [PDF] [Supplemental Data]  
Developmental exposure to the pesticide methoxychlor leads to DNA methylation changes in the ovary.

F. Francavilla, N. Battista, A. Barbonetti, M. R. C. Vassallo, C. Rapino, C. Antonangelo, N. Pasquariello, G. Catanzaro, B. Barboni, and M. Maccarrone

Characterization of the Endocannabinoid System in Human Spermatozoa and Involvement of Transient Receptor Potential Vanilloid 1 Receptor in Their Fertilizing Ability
Endocrinology 2009 150: 4692-4700 , doi:10.1210/en.2009-0057 [Abstract] [Full Text] [PDF]  
Human spermatozoa exhibit a functional endocannabinoid system related to anandamide (AEA), and AEA-binding vanilloid receptor is involved in the sperm fertilizing ability.

Michael C. Velarde, Lusine Aghajanova, Camran R. Nezhat, and Linda C. Giudice

Increased Mitogen-Activated Protein Kinase Kinase/Extracellularly Regulated Kinase Activity in Human Endometrial Stromal Fibroblasts of Women with Endometriosis Reduces 3',5'-Cyclic Adenosine 5'-Monophosphate Inhibition of Cyclin D1
Endocrinology 2009 150: 4701-4712 , doi:10.1210/en.2009-0389 [Abstract] [Full Text] [PDF]  
Increased activation of MEK/ERK inhibits cAMP-dependent cell cycle regulation and promotes sustained cell proliferation in human endometrial stromal fibroblasts of women with endometriosis.

Elissa W. P. Wong, Shengyi Sun, Michelle W. M. Li, Will M. Lee, and C. Yan Cheng

14-3-3 Protein Regulates Cell Adhesion in the Seminiferous Epithelium of Rat Testes
Endocrinology 2009 150: 4713-4723 , doi:10.1210/en.2009-0427 [Abstract] [Full Text] [PDF] [Supplemental Data]  
14-3-3 regulates cell adhesion at the blood-testis barrier via its effects on the kinetics of protein endocytosis.

Ilona A. Kopera, Linlin Su, Barbara Bilinska, C. Yan Cheng, and Dolores D. Mruk

An in Vivo Study on Adjudin and Blood-Testis Barrier Dynamics
Endocrinology 2009 150: 4724-4733 , doi:10.1210/en.2008-1779 [Abstract] [Full Text] [PDF] [Supplemental Data]  
Adjudin, a male contraceptive compound, affects the blood-testis barrier assembly in postnatal rats.

Kun Qian, Linli Hu, Hong Chen, Haixia Li, Na Liu, Yufeng Li, Jihui Ai, Guijin Zhu, Zhouping Tang, and Hanwang Zhang

Hsa-miR-222 Is Involved in Differentiation of Endometrial Stromal Cells in Vitro
Endocrinology 2009 150: 4734-4743 , doi:10.1210/en.2008-1629 [Abstract] [Full Text] [PDF] [Supplemental Data]  
Hsa-miR-222 participates in endometrial stromal cell (ESC) differentiation by regulating ESC terminal withdrawl from the cell cycle, in part by permitting CDKN1C/p57 expression.

Karen Forbes, Gemma West, Rebecca Garside, John D. Aplin, and Melissa Westwood

The Protein-Tyrosine Phosphatase, Src Homology-2 Domain Containing Protein Tyrosine Phosphatase-2, Is a Crucial Mediator of Exogenous Insulin-Like Growth Factor Signaling to Human Trophoblast
Endocrinology 2009 150: 4744-4754 , doi:10.1210/en.2009-0166 [Abstract] [Full Text] [PDF]  
SHP-2 regulates the decision by human cytotrophoblast to grow or differentiate by modulating the profile of signaling molecules activated in response to IGF-I.

Patrick Lim, Mathew Robson, Jenny Spaliviero, Kirsten J. McTavish, Mark Jimenez, Jeffrey D. Zajac, David J. Handelsman, and Charles M. Allan

Sertoli Cell Androgen Receptor DNA Binding Domain Is Essential for the Completion of Spermatogenesis
Endocrinology 2009 150: 4755-4765 , doi:10.1210/en.2009-0416 [Abstract] [Full Text] [PDF] [Supplemental Data]  
Sertoli cell-specific inactivation of the AR DNA-binding domain dose-dependently disrupts spermatogenic postmeiotic then meiotic development, and reveals differential temporal control of distinct androgen-regulated genes.

Marie-Noëlle Raymond, Philippe Robin, Federica De Zen, Ginette Vilain, and Zahra Tanfin

Differential Endothelin Receptor Expression and Function in Rat Myometrial Cells and Leiomyoma ELT3 Cells
Endocrinology 2009 150: 4766-4776 , doi:10.1210/en.2009-0118 [Abstract] [Full Text] [PDF] [Supplemental Data]  
The capacity of rat leiomyoma ELT3 cells to highly proliferate in response to endothelin-1 is associated with the overexpression of the endothelin B receptor.

Bryony A. McNeill, Graham K. Barrell, Martin Wellby, Timothy C. R. Prickett, Timothy G. Yandle, and Eric A. Espiner

C-Type Natriuretic Peptide Forms in Pregnancy: Maternal Plasma Profiles during Ovine Gestation Correlate with Placental and Fetal Maturation
Endocrinology 2009 150: 4777-4783 , doi:10.1210/en.2009-0176 [Abstract] [Full Text] [PDF]  
Strong links of CNP production to ovine placentation and fetal maturation are shown by distinctive changes in maternal plasma concentrations of CNP forms during gestation, positive relation with fetal number, and greatly elevated concentrations of CNP proteins in the placentome.

Yogeshwar Makanji, Peter D. Temple-Smith, Kelly L. Walton, Craig A. Harrison, and David M. Robertson

Inhibin B Is a More Potent Suppressor of Rat Follicle-Stimulating Hormone Release than Inhibin A in Vitro and in Vivo
Endocrinology 2009 150: 4784-4793 , doi:10.1210/en.2008-1783 [Abstract] [Full Text] [PDF] [Supplemental Data]  
The increased bioactivity of inhibin B compared to inhibin A is not explained by affinities to known receptors and may be mediated by additional proteins.

Suman Rice, Laura Pellatt, Kumaran Ramanathan, Saffron Anne Whitehead, and Helen Diane Mason

Metformin Inhibits Aromatase via an Extracellular Signal-Regulated Kinase-Mediated Pathway
Endocrinology 2009 150: 4794-4801 , doi:10.1210/en.2009-0540 [Abstract] [Full Text] [PDF]  
Metformin inhibits expression and activity of aromatase, a concern considering its widespread use as a treatment in PCOS.

Joseph P. Moore, Jr., Betty C. Villafuerte, Christian A. Unick, and Stephen J. Winters

Developmental Changes in Pituitary Adenylate Cyclase Activating Polypeptide Expression during the Perinatal Period: Possible Role in Fetal Gonadotroph Regulation
Endocrinology 2009 150: 4802-4809 , doi:10.1210/en.2008-1649 [Abstract] [Full Text] [PDF]  
Findings support the hypothesis that pituitary adenylate cyclase activating polypeptide (PACAP) is involved in the suppression of FSH mRNA expression in the fetus, and that a pronounced perinatal decline in pituitary PACAP expression facilitates a dramatic rise in FSH expression.

TECHNICAL COMMUNICATIONS:

Marcello Mancini, Emilia Vergara, Giuliana Salvatore, Adelaide Greco, Giancarlo Troncone, Andrea Affuso, Raffaele Liuzzi, Paolo Salerno, Maria Scotto di Santolo, Massimo Santoro, Arturo Brunetti, and Marco Salvatore

Morphological Ultrasound Microimaging of Thyroid in Living Mice
Endocrinology 2009 150: 4810-4815 , doi:10.1210/en.2009-0417 [Abstract] [Full Text] [PDF]  
The High Frequency Ultrasound is an imaging modality that can be helpful in research concerning thyroid pathology in animal models.

TRANSLATIONAL HIGHLIGHTS FROM JCEM:

Steven A. Lietman, Yardena Tenenbaum-Rakover, Tjin Shing Jap, Wu Yi-Chi, Yang De-Ming, Changlin Ding, Najat Kussiny, and Michael A. Levine

A Novel Loss-of-Function Mutation, Gln459Arg, of the Calcium-Sensing Receptor Gene Associated with Apparent Autosomal Recessive Inheritance of Familial Hypocalciuric Hypercalcemia
Endocrinology 2009 150: 4816 [Full Text] [PDF]  

J. Smith, K. Cianflone, S. Biron, F. S. Hould, S. Lebel, S. Marceau, O. Lescelleur, L. Biertho, S. Simard, J. G. Kral, and P. Marceau

Effects of Bariatric Surgical Weight Loss in Mothers on Intergenerational Transmission of Obesity
Endocrinology 2009 150: 4816-a [Full Text] [PDF]  

Channa N. Jayasena, Gurjinder K. Nijher, Owais B. Chaudhri, Kevin G. Murphy, Amita Ranger, Adrian Lim, Daksha Patel, Amrish Mehta, Catriona Todd, Radha Ramachandran, Victoria Salem, Gordon W. Stamp, Mandy Donaldson, Mohammad A. Ghatei, Stephen R. Bloom, and Waljit S. Dhillo

Subcutaneous Injection of Kisspeptin-54 Acutely Stimulates Gonadotropin Secretion in Women with Hypothalamic Amenorrhea, But Chronic Administration Causes Tachyphylaxis
Endocrinology 2009 150: 4817 [Full Text] [PDF]  

Robert H. Coker, Rick H. Williams, Sophie E. Yeo, Patrick M. Kortebein, Don L. Bodenner, Philip A. Kern, and William J. Evans

The Impact of Exercise Training Compared to Caloric Restriction on Hepatic and Peripheral Insulin Resistance in Obesity
Endocrinology 2009 150: 4817-a [Full Text] [PDF]  

To see an article, click its [Full Text] link. To review many abstracts, check the boxes to the left of the titles you want, and click the 'Get All Checked Abstract(s)' button. To see one abstract at a time, click its [Abstract] link.