NEWS AND VIEWS:

John R. G. Challis and Kristin Connor

Glucocorticoids, 11β-Hydroxysteroid Dehydrogenase: Mother, Fetus, or Both?
Endocrinology 2009 150: 1073-1074, doi:10.1210/en.2008-1577 [Full Text] [PDF]  

Tara S. Perrot-Sinal

Do These Genes Make Me Look Fat?
Endocrinology 2009 150: 1075-1077, doi:10.1210/en.2008-1586 [Full Text] [PDF]  

MINIREVIEWS:

Heike Heuer and Theo J. Visser

Pathophysiological Importance of Thyroid Hormone Transporters
Endocrinology 2009 150: 1078-1083, doi:10.1210/en.2008-1518 [Abstract] [Full Text] [PDF]  
Specific thyroid hormone transporters may be discovered in the near future, leading to a better understanding of the tissue-specific regulation of thyroid hormone bioavailability.

Aigerim Bizhanova and Peter Kopp

The Sodium-Iodide Symporter NIS and Pendrin in Iodide Homeostasis of the Thyroid
Endocrinology 2009 150: 1084-1090, doi:10.1210/en.2008-1437 [Abstract] [Full Text] [PDF]  
This review shows how the sodium-iodide symporter mediates the active transport of iodide at the basolateral membrane of thyrocytes and discusses biallelic mutations in NIS and the effects of pendrin.

Maria Izabel Chiamolera and Fredric E. Wondisford

Thyrotropin-Releasing Hormone and the Thyroid Hormone Feedback Mechanism
Endocrinology 2009 150: 1091-1096, doi:10.1210/en.2008-1795 [Abstract] [Full Text] [PDF]  
The thyrotropin-releasing hormone neuron is well-positioned to integrate information about the environment as well as circulating TH levels and ultimately affect metabolism in response to these physiological changes.

Donald L. St. Germain, Valerie Anne Galton, and Arturo Hernandez

Defining the Roles of the Iodothyronine Deiodinases: Current Concepts and Challenges
Endocrinology 2009 150: 1097-1107, doi:10.1210/en.2008-1588 [Abstract] [Full Text] [PDF]  
This review assesses the functional roles of TH action and others proposed for the deiodinases and examines current challenges in expanding knowledge of these components of the thyroid homeostatic system.

Thomas S. Scanlan

3-Iodothyronamine (T₁AM): A New Player on the Thyroid Endocrine Team?
Endocrinology 2009 150: 1108-1111, doi:10.1210/en.2008-1596 [Abstract] [Full Text] [PDF]  
3-Iodothyronamine is a biologically active, endogenous derivative of thyroid hormone that may represent a new arm of the thyroid endocrine system.

CANCER - ONCOGENES:

Scott M. Belcher, Xiaolan Ma, and Hoa H. Le

Blockade of Estrogen Receptor Signaling Inhibits Growth and Migration of Medulloblastoma
Endocrinology 2009 150: 1112-1121, doi:10.1210/en.2008-1363 [Abstract] [Full Text] [PDF]  
Estrogens, via ERβ, stimulate growth of medulloblastoma. ICI182,780 and the antiestrogen drug Faslodex block estrogen-stimulated tumor growth in vitro and in xenograft models of medulloblastoma.

Yi Xie, Sutapa Kole, Patricia Precht, Michael J. Pazin, and Michel Bernier

S-Glutathionylation Impairs Signal Transducer and Activator of Transcription 3 Activation and Signaling
Endocrinology 2009 150: 1122-1131, doi:10.1210/en.2008-1241 [Abstract] [Full Text] [PDF] [Supplemental Data]  
Reversible S-glutathionylation of STAT3 regulates its activity as transcription factor.

DIABETES - INSULIN - GLUCAGON - GASTROINTESTINAL:

Sara J. Ernst, Lydia Aguilar-Bryan, and Jeffrey L. Noebels

Sodium Channel β1 Regulatory Subunit Deficiency Reduces Pancreatic Islet Glucose-Stimulated Insulin and Glucagon Secretion
Endocrinology 2009 150: 1132-1139, doi:10.1210/en.2008-0991 [Abstract] [Full Text] [PDF]  
This genetic mouse model establishes an essential role for voltage-gated sodium channels in the physiological excitation-release pathway mediating pancreatic glucose homeostasis.

Lena Persson, Cecilia Gälman, Bo Angelin, and Mats Rudling

Importance of Proprotein Convertase Subtilisin/Kexin Type 9 in the Hormonal and Dietary Regulation of Rat Liver Low-Density Lipoprotein Receptors
Endocrinology 2009 150: 1140-1146, doi:10.1210/en.2008-1281 [Abstract] [Full Text] [PDF]  
PCSK9, which reduces LDL-receptors by posttranscriptional mechanisms, is involved in the hormonal stimulation of LDL receptors by glucagon and estrogens.

Akinobu Nakamura, Yasuo Terauchi, Sumika Ohyama, Junko Kubota, Hiroko Shimazaki, Tadahiro Nambu, Iseki Takamoto, Naoto Kubota, Junichi Eiki, Narihito Yoshioka, Takashi Kadowaki, and Takao Koike

Impact of Small-Molecule Glucokinase Activator on Glucose Metabolism and β-Cell Mass
Endocrinology 2009 150: 1147-1154, doi:10.1210/en.2008-1183 [Abstract] [Full Text] [PDF] [Supplemental Data]  
Glucokinase activator is able to improve glucose metabolism and has an effect on β cell proliferation.

Julio E. Ayala, Deanna P. Bracy, Freyja D. James, Brianna M. Julien, David H. Wasserman, and Daniel J. Drucker

The Glucagon-Like Peptide-1 Receptor Regulates Endogenous Glucose Production and Muscle Glucose Uptake Independent of Its Incretin Action
Endocrinology 2009 150: 1155-1164, doi:10.1210/en.2008-0945 [Abstract] [Full Text] [PDF]  
During increased glucose flux, the glucagon-like peptide-1 receptor regulates endogenous glucose production and muscle glucose uptake independent of its ability to stimulate insulin secretion.

Rebecca Adochio, J. Wayne Leitner, Reed Hedlund, and Boris Draznin

Rescuing 3T3-L1 Adipocytes from Insulin Resistance Induced by Stimulation of Akt-Mammalian Target of Rapamycin/p70 S6 Kinase (S6K1) Pathway and Serine Phosphorylation of Insulin Receptor Substrate-1: Effect of Reduced Expression of p85 Subunit of Phosphatidylinositol 3-Kinase and S6K1 Kinase
Endocrinology 2009 150: 1165-1173, doi:10.1210/en.2008-0437 [Abstract] [Full Text] [PDF]  
Reduced expression of p85 or p70 S6 kinase rescues adipocytes from insulin resistance induced by serine phosphorylation of insulin receptor substrate-1 and restores phosphatidylinositol 3-kinase activity and glucose uptake

ENERGY BALANCE - OBESITY:

Elisabeth B. Rüttimann, Myrtha Arnold, Jacquelien J. Hillebrand, Nori Geary, and Wolfgang Langhans

Intrameal Hepatic Portal and Intraperitoneal Infusions of Glucagon-Like Peptide-1 Reduce Spontaneous Meal Size in the Rat via Different Mechanisms
Endocrinology 2009 150: 1174-1181, doi:10.1210/en.2008-1221 [Abstract] [Full Text] [PDF]  
Intrameal hepatic portal and intraperitoneal (IP) infusions of GLP-1 reduce meal size in rats, but only IP GLP-1 requires vagal afferent signaling for this effect.

Yacir Benomar, Flavien Berthou, Claire-Marie Vacher, Virginie Bailleux, Arieh Gertler, Jean Djiane, and Mohammed Taouis

Leptin But Not Ciliary Neurotrophic Factor (CNTF) Induces Phosphotyrosine Phosphatase-1B Expression in Human Neuronal Cells (SH-SY5Y): Putative Explanation of CNTF Efficacy in Leptin-Resistant State
Endocrinology 2009 150: 1182-1191, doi:10.1210/en.2008-1097 [Abstract] [Full Text] [PDF]  
Phosphotyrosine phosphatase 1B has a critical role in the onset of neuronal leptin resistance and is unable to inhibit CNTF-dependent signaling pathways in leptin-resistant states.

Zakaria El Kebbaj, Pierre Andreoletti, Driss Mountassif, Mostafa Kabine, Hervé Schohn, Michel Dauça, Norbert Latruffe, M'Hammed Saïd El Kebbaj, and Mustapha Cherkaoui-Malki

Differential Regulation of Peroxisome Proliferator-Activated Receptor (PPAR)-1 and Truncated PPAR2 as an Adaptive Response to Fasting in the Control of Hepatic Peroxisomal Fatty Acid β-Oxidation in the Hibernating Mammal
Endocrinology 2009 150: 1192-1201, doi:10.1210/en.2008-1394 [Abstract] [Full Text] [PDF]  
Jerboa PPAR is subject to a hibernation-dependent splicing regulation in response to feeding-fasting conditions, which define activation of PPAR and its target genes.

John-Paul Baird, Angela Choe, Jasmine L. Loveland, Janine Beck, Carrie E. Mahoney, Julia S. Lord, and Lindsay A. Grigg

Orexin-A Hyperphagia: Hindbrain Participation in Consummatory Feeding Responses
Endocrinology 2009 150: 1202-1216, doi:10.1210/en.2008-0293 [Abstract] [Full Text] [PDF]  
Orexin-A increases meal size via gut feedback disinhibition, not enhanced gustatory evaluation. Medullary lesions abolish meal size but not frequency increases, indicating dissociable sites for orexin-A feeding actions.

Bing Li, Jonghyun Shin, and Kichoon Lee

Interferon-Stimulated Gene ISG12b1 Inhibits Adipogenic Differentiation and Mitochondrial Biogenesis in 3T3-L1 Cells
Endocrinology 2009 150: 1217-1224, doi:10.1210/en.2008-0727 [Abstract] [Full Text] [PDF]  
ISG12b1 is predominantly expressed in adipocytes and dramatically induced at the terminal stage of adipogenesis. Functionally, mitochondria-localized ISG12b1 inhibits adipogenic differentiation and mitochondria biogenesis.

Shin-ichi Oka, Eiji Yoshihara, Akiko Bizen-Abe, Wenrui Liu, Mutsumi Watanabe, Junji Yodoi, and Hiroshi Masutani

Thioredoxin Binding Protein-2/Thioredoxin-Interacting Protein Is a Critical Regulator of Insulin Secretion and Peroxisome Proliferator-Activated Receptor Function
Endocrinology 2009 150: 1225-1234, doi:10.1210/en.2008-0646 [Abstract] [Full Text] [PDF] [Supplemental Data]  
TBP-2/Txnip is a key regulator of PPAR expression and signaling, and coordinated regulation of PPAR and insulin secretion by TBP-2/Txnip is crucial in fasting response.

GENERAL ENDOCRINOLOGY:

Atila van Nas, Debraj GuhaThakurta, Susanna S. Wang, Nadir Yehya, Steve Horvath, Bin Zhang, Leslie Ingram-Drake, Gautam Chaudhuri, Eric E. Schadt, Thomas A. Drake, Arthur P. Arnold, and Aldons J. Lusis

Elucidating the Role of Gonadal Hormones in Sexually Dimorphic Gene Coexpression Networks
Endocrinology 2009 150: 1235-1249, doi:10.1210/en.2008-0563 [Abstract] [Full Text] [PDF] [Supplemental Data]  
Higher order gene interactions differ between sexes and are determined primarily by sex hormones.

J. D. Spencer and K. U. Schallreuter

Regulation of Pigmentation in Human Epidermal Melanocytes by Functional High-Affinity β-Melanocyte-Stimulating Hormone/Melanocortin-4 Receptor Signaling
Endocrinology 2009 150: 1250-1258, doi:10.1210/en.2008-1212 [Abstract] [Full Text] [PDF]  
Although a high affinity MC4-R signal in human epidermal melanocytes (3,600 receptors/cell) stimulates melanogenesis via the β-MSH /cAMP/MITF/tyrosinase cascade, the purpose of this signal in keratinocytes remains unclear.

Rajan Singh, Shalender Bhasin, Melissa Braga, Jorge N. Artaza, Shehla Pervin, Wayne E. Taylor, Venkatesh Krishnan, Satyesh K. Sinha, Tripathi B. Rajavashisth, and Ravi Jasuja

Regulation of Myogenic Differentiation by Androgens: Cross Talk between Androgen Receptor/ β-Catenin and Follistatin/Transforming Growth Factor-β Signaling Pathways
Endocrinology 2009 150: 1259-1268, doi:10.1210/en.2008-0858 [Abstract] [Full Text] [PDF]  
Androgen-induced myogenic differentiation in mouse multipotent C3H 10T1/2 cells is mediated through androgen receptor/β-catenin signaling pathway to upregulate follistatin and cross-communication with TGF-β/Smad signaling pathway.

Maximilian Bielohuby, Mandy Sawitzky, Inga Johnsen, Dörte Wittenburg, Felix Beuschlein, Eckhard Wolf, and Andreas Hoeflich

Decreased p44/42 Mitogen-Activated Protein Kinase Phosphorylation in Gender- or Hormone-Related But Not during Age-Related Adrenal Gland Growth in Mice
Endocrinology 2009 150: 1269-1277, doi:10.1210/en.2008-1055 [Abstract] [Full Text] [PDF]  
In three independent mouse models it is shown that elevated adrenal growth (sex-related, ACTH-induced or GH-dependent growth) is associated with partial inactivation of p44/42 mitogen-activated protein kinase.

Tomer Ventura, Rivka Manor, Eliahu D. Aflalo, Simy Weil, Shaul Raviv, Lilah Glazer, and Amir Sagi

Temporal Silencing of an Androgenic Gland-Specific Insulin-Like Gene Affecting Phenotypical Gender Differences and Spermatogenesis
Endocrinology 2009 150: 1278-1286, doi:10.1210/en.2008-0906 [Abstract] [Full Text] [PDF]  
Temporal silencing of a newly identified insulin-like gene from prawn androgenic gland inhibits primary spermatogenesis, male secondary sex characteristics, and growth.

GLUCOCORTICOIDS-CRH-ACTH-ADRENAL:

Caitlin S. Wyrwoll, Jonathan R. Seckl, and Megan C. Holmes

Altered Placental Function of 11β-Hydroxysteroid Dehydrogenase 2 Knockout Mice
Endocrinology 2009 150: 1287-1293, doi:10.1210/en.2008-1100 [Abstract] [Full Text] [PDF]  
Restriction of fetal growth in 11β-HSD2-/- mice is mediated, at least in part, via altered placental transport of nutrients and a reduction in placental vascularization.

Jose Maria Rincon Garriz, Catherine Suarez, and Alessandro M. Capponi

c-Fos Mediates Angiotensin II-Induced Aldosterone Production and Protein Synthesis in Bovine Adrenal Glomerulosa Cells
Endocrinology 2009 150: 1294-1302, doi:10.1210/en.2008-1036 [Abstract] [Full Text] [PDF]  
In adrenal glomerulosa cells, angiotensin II induces expression and phosphorylation of c-Fos, which mediates the peptide’s effects on StAR gene expression, aldosterone production and protein synthesis.

Ping Ye, Yashuhiro Nakamura, Enzo Lalli, and William E. Rainey

Differential Effects of High and Low Steroidogenic Factor-1 Expression on CYP11B2 Expression and Aldosterone Production in Adrenocortical Cells
Endocrinology 2009 150: 1303-1309, doi:10.1210/en.2008-0667 [Abstract] [Full Text] [PDF]  
In adrenocortical cells high versus low levels of SF-1 differentially regulate the expression of aldosterone synthase and aldosterone production.

GROWTH FACTORS-CYTOKINES:

Ebru Karpuzoglu, Rebecca A. Phillips, Rujuan Dai, Carmine Graniello, Robert M. Gogal, Jr., and S. Ansar Ahmed

Signal Transducer and Activation of Transcription (STAT) 4β, a Shorter Isoform of Interleukin-12-Induced STAT4, Is Preferentially Activated by Estrogen
Endocrinology 2009 150: 1310-1320, doi:10.1210/en.2008-0832 [Abstract] [Full Text] [PDF]  
IL-12 activates cells through STAT4 signaling. Two isoforms of STAT4 have now been identified: a normal-sized STAT4 and a shorter STAT4β. Estrogens preferentially activate STAT4β isoform.

Lee B. Allen, Byron E. Capps, Emily C. Miller, David R. Clemmons, and Laura A. Maile

Glucose-Oxidized Low-Density Lipoproteins Enhance Insulin-Like Growth Factor I-Stimulated Smooth Muscle Cell Proliferation by Inhibiting Integrin-Associated Protein Cleavage
Endocrinology 2009 150: 1321-1329, doi:10.1210/en.2008-1090 [Abstract] [Full Text] [PDF] [Supplemental Data]  
The glucose-oxidized low-density lipoprotein stimulated decrease in integrin-associated protein (IAP) cleavage, leading to an increase in IAP association with SHPS-1, mediates its enhancing effects on IGF-I stimulated proliferation.

Cheryl L. Ackert-Bicknell, Keith R. Shockley, Lindsay G. Horton, Beata Lecka-Czernik, Gary A. Churchill, and Clifford J. Rosen

Strain-Specific Effects of Rosiglitazone on Bone Mass, Body Composition, and Serum Insulin-Like Growth Factor-I
Endocrinology 2009 150: 1330-1340, doi:10.1210/en.2008-0936 [Abstract] [Full Text] [PDF]  
Treatment of four inbred strains of mice with rosiglitazone results in very distinct skeletal and metabolic responses, suggesting an important genotype by drug interaction.

GROWTH HORMONE - SOMATOSTATIN - GRH:

Severine E. Brunet-Dunand, Cecile Vouyovitch, Silvia Araneda, Vijay Pandey, Laurent J.-P. Vidal, Cristin Print, Hichem C. Mertani, Peter E. Lobie, and Jo K. Perry

Autocrine Human Growth Hormone Promotes Tumor Angiogenesis in Mammary Carcinoma
Endocrinology 2009 150: 1341-1352, doi:10.1210/en.2008-0608 [Abstract] [Full Text] [PDF] [Supplemental Data]  
Autocrine/paracrine human growth hormone secreted by mammary carcinoma cells increases in vitro and in vivo indices of angiogenesis and lymphangiogenesis.

Amanda J. Palmer, Min-Yu Chung, Edward O. List, Jennifer Walker, Shigeru Okada, John J. Kopchick, and Darlene E. Berryman

Age-Related Changes in Body Composition of Bovine Growth Hormone Transgenic Mice
Endocrinology 2009 150: 1353-1360, doi:10.1210/en.2008-1199 [Abstract] [Full Text] [PDF]  
Longitudinal assessment of body composition in GH transgenic mice reveals novel age dependent and gender-specific effects of GH on adiopse tissue.

NEUROENDOCRINOLOGY:

Adhanet H. Kidane, Gerhard Heinrich, Ron P. H. Dirks, Brechje A. de Ruyck, Nicolette H. Lubsen, Eric W. Roubos, and Bruce G. Jenks

Differential Neuroendocrine Expression of Multiple Brain-Derived Neurotrophic Factor Transcripts
Endocrinology 2009 150: 1361-1368, doi:10.1210/en.2008-0993 [Abstract] [Full Text] [PDF]  
We show promoter-specific expression of BDNF transcripts in neuroendocrine melanotrope cells and provide evidence that upstream open reading frames of BDNF transcripts decrease translation efficiency.

John Kuo, Omid R. Hariri, Galyna Bondar, Julie Ogi, and Paul Micevych

Membrane Estrogen Receptor- Interacts with Metabotropic Glutamate Receptor Type 1a to Mobilize Intracellular Calcium in Hypothalamic Astrocytes
Endocrinology 2009 150: 1369-1376, doi:10.1210/en.2008-0994 [Abstract] [Full Text] [PDF]  
For rapid 17β-estradiol-induced membrane signaling in hypothalamic astrocytes, mER- must interact with mGluR1a resulting in a dramatic increase in free cytoplasmic calcium concentration within seconds.

Catherine Pasqualini, Finn-Arne Weltzien, Bernadette Vidal, Sylvie Baloche, Céline Rouget, Nicolas Gilles, Denis Servent, Philippe Vernier, and Sylvie Dufour

Two Distinct Dopamine D2 Receptor Genes in the European Eel: Molecular Characterization, Tissue-Specific Transcription, and Regulation by Sex Steroids
Endocrinology 2009 150: 1377-1392, doi:10.1210/en.2008-0578 [Abstract] [Full Text] [PDF]  
Two genes encoding dopamine D2 receptors are present in the European eel. Their transcription is tissue-specific and differentially regulated by androgens.

H. Kudo, J. Liu, E. J. R. Jansen, A. Ozawa, P. Panula, G. J. M. Martens, and I. Lindberg

Identification of proSAAS Homologs in Lower Vertebrates: Conservation of Hydrophobic Helices and Convertase-Inhibiting Sequences
Endocrinology 2009 150: 1393-1399, doi:10.1210/en.2008-1301 [Abstract] [Full Text] [PDF]  
The identification of two proSAAS molecules in lower vertebrates provides clues as to functional regions within this widely-expressed neuroendocrine protein.

Stephanie Constantin, Claudia Simone Caligioni, Stanko Stojilkovic, and Susan Wray

Kisspeptin-10 Facilitates a Plasma Membrane-Driven Calcium Oscillator in Gonadotropin-Releasing Hormone-1 Neurons
Endocrinology 2009 150: 1400-1412, doi:10.1210/en.2008-0979 [Abstract] [Full Text] [PDF]  
GnRH-1 neurons exhibit a spontaneously active calcium oscillator, dependent on tetrodotoxin-sensitive sodium conductance. Kisspeptin-10/GPR54, via phosphatidyl inositol diphosphate 2 hydrolysis, utilizes these channels and non-selective cationic channels.

Mohammed Z. Rizwan, Robert Porteous, Allan E. Herbison, and Greg M. Anderson

Cells Expressing RFamide-Related Peptide-1/3, the Mammalian Gonadotropin-Inhibitory Hormone Orthologs, Are Not Hypophysiotropic Neuroendocrine Neurons in the Rat
Endocrinology 2009 150: 1413-1420, doi:10.1210/en.2008-1287 [Abstract] [Full Text] [PDF]  
Hypothalamic RFRP-1/3 neurons project to the preoptic area and hippocampus but not the median eminence, suggesting that RFRP-1/3 is not a hypophysiotropic gonadotropin inhibitor in the rat.

RENAL - CARDIAC - VASCULAR:

Laurent Yvan-Charvet, Florence Massiéra, Noël Lamandé, Gérard Ailhaud, Michèle Teboul, Naima Moustaid-Moussa, Jean-Marie Gasc, and Annie Quignard-Boulangé

Deficiency of Angiotensin Type 2 Receptor Rescues Obesity But Not Hypertension Induced by Overexpression of Angiotensinogen in Adipose Tissue
Endocrinology 2009 150: 1421-1428, doi:10.1210/en.2008-1120 [Abstract] [Full Text] [PDF]  
Angiotensin type 2 receptor shows antihypertensive function but promotes the angiotensin II-mediated fat mass enlargement.

Nathalie Fiaschi-Taesch, Brian Sicari, Kiran Ubriani, Irene Cozar-Castellano, Karen K. Takane, and Andrew F. Stewart

Mutant Parathyroid Hormone-Related Protein, Devoid of the Nuclear Localization Signal, Markedly Inhibits Arterial Smooth Muscle Cell Cycle and Neointima Formation by Coordinate Up-Regulation of p15^Ink4b and p27^kip1
Endocrinology 2009 150: 1429-1439, doi:10.1210/en.2008-0737 [Abstract] [Full Text] [PDF] [Supplemental Data]  
This study provides the mechanistic underpinnings for understanding how -NLS-PTHrP functions, and suggests that -NLS-PTHrP may have particular efficacy for the prevention of arterial re-stenosis.

Mogher Khamaisi, Rachel Dahan, Saher Hamed, Zaid Abassi, Samuel N. Heyman, and Itamar Raz

Role of Protein Kinase C in the Expression of Endothelin Converting Enzyme-1
Endocrinology 2009 150: 1440-1449, doi:10.1210/en.2008-0524 [Abstract] [Full Text] [PDF]  
Hyperglycemia-induced enhanced endothelin converting enzyme-1 expression is mediated by PKC-. Inhibition of this PKC isoform may prevent diabetes-related increase in endothelin-1.

Yasuko Torigoe, Naohiko Takahashi, Masahide Hara, Hironobu Yoshimatsu, and Tetsunori Saikawa

Adrenomedullin Improves Cardiac Expression of Heat-Shock Protein 72 and Tolerance against Ischemia/Reperfusion Injury in Insulin-Resistant Rats
Endocrinology 2009 150: 1450-1455, doi:10.1210/en.2008-1052 [Abstract] [Full Text] [PDF]  
Adrenomedullin pretreatment enhances hyperthermia-induced PI3 kinase-dependent myocardial Akt phosphorylation and HSP72 expression even in insulin-resistant rat heart, which is associated with tolerance against ischemia/reperfusion injury.

REPRODUCTION - DEVELOPMENT:

Teresa L. Steckler, Carol Herkimer, Daniel A. Dumesic, and Vasantha Padmanabhan

Developmental Programming: Excess Weight Gain Amplifies the Effects of Prenatal Testosterone Excess On Reproductive Cyclicity—Implication for Polycystic Ovary Syndrome
Endocrinology 2009 150: 1456-1465, doi:10.1210/en.2008-1256 [Abstract] [Full Text] [PDF]  
Exposure of sheep to excess testosterone in utero disrupts reproductive cyclicity, with postpubertal excess weight gain amplifying the severity of this adult reproductive phenotype.

Fahimeh Rahnama, Bridget Thompson, Michael Steiner, Farhad Shafiei, Peter E. Lobie, and Murray D. Mitchell

Epigenetic Regulation of E-Cadherin Controls Endometrial Receptivity
Endocrinology 2009 150: 1466-1472, doi:10.1210/en.2008-1142 [Abstract] [Full Text] [PDF]  
Inhibition of DNA methylation increases both E-cadherin expression and receptivity in an endometrial cell line, suggesting that endometrial receptivity in human pregnancy is epigenetically regulated.

S. Priyanka, P. Jayaram, R. Sridaran, and R. Medhamurthy

Genome-Wide Gene Expression Analysis Reveals a Dynamic Interplay between Luteotropic and Luteolytic Factors in the Regulation of Corpus Luteum Function in the Bonnet Monkey (Macaca radiata)
Endocrinology 2009 150: 1473-1484, doi:10.1210/en.2008-0840 [Abstract] [Full Text] [PDF] [Supplemental Data]  
Results of genome-wide analyses suggest that curtailment of expression of LH target-genes through PGF2 action in corpus luteum involves cross talk between luteotropic and luteolytic signaling pathways.

Mark D. Aupperlee, Alexis A. Drolet, Srinivasan Durairaj, Weizhong Wang, Richard C. Schwartz, and Sandra Z. Haslam

Strain-Specific Differences in the Mechanisms of Progesterone Regulation of Murine Mammary Gland Development
Endocrinology 2009 150: 1485-1494, doi:10.1210/en.2008-1459 [Abstract] [Full Text] [PDF]  
Reduced progesterone-induced expression of progesterone receptor and RANKL, altered expression and regulation of C/EBPβ, and of the downstream effectors of RANKL, nuclear Id2 and p21, contribute significantly to the reduced progesterone-responsiveness of the C57BL/6 mammary gland compared to the BALB/c gland.

Chrishan S. Samuel, Simon G. Royce, Bin Chen, Huifang Cao, Jan A. Gossen, Geoffrey W. Tregear, and Mimi L. K. Tang

Relaxin Family Peptide Receptor-1 Protects against Airway Fibrosis during Homeostasis But Not against Fibrosis Associated with Chronic Allergic Airways Disease
Endocrinology 2009 150: 1495-1502, doi:10.1210/en.2008-1062 [Abstract] [Full Text] [PDF]  
The relaxin receptor RXFP1 is involved in mediating relaxin’s effects on airway fibrosis during homeostasis, but not during inflammation-induced fibrosis associated with chronic allergic airways disease.

Yasuhisa Kobayashi, Masaru Nakamura, Tomoki Sunobe, Takeshi Usami, Tohru Kobayashi, Hisaya Manabe, Bindhu Paul-Prasanth, Norio Suzuki, and Yoshitaka Nagahama

Sex Change in the Gobiid Fish Is Mediated through Rapid Switching of Gonadotropin Receptors from Ovarian to Testicular Portion or Vice Versa
Endocrinology 2009 150: 1503-1511, doi:10.1210/en.2008-0569 [Abstract] [Full Text] [PDF]  
Gonadal sex-change in goby, in response to social cue, is mediated through a rapid switching in the expression of GtH receptors in the gonads.

Antonina Frolova, Lauren Flessner, Maggie Chi, Sung Tae Kim, Nastaran Foyouzi-Yousefi, and Kelle H. Moley

Facilitative Glucose Transporter Type 1 Is Differentially Regulated by Progesterone and Estrogen in Murine and Human Endometrial Stromal Cells
Endocrinology 2009 150: 1512-1520, doi:10.1210/en.2008-1081 [Abstract] [Full Text] [PDF] [Supplemental Data]  
GLUT1 expression increases during decidualization of endometrial stromal cells in vitro. Progesterone upregulates and estrogen downregulates GLUT1 expression and glucose uptake in these cells.

Randy L. Bogan, Melinda J. Murphy, and Jon D. Hennebold

Dynamic Changes in Gene Expression that Occur during the Period of Spontaneous Functional Regression in the Rhesus Macaque Corpus Luteum
Endocrinology 2009 150: 1521-1529, doi:10.1210/en.2008-1201 [Abstract] [Full Text] [PDF] [Supplemental Data]  
Genes differentially expressed during spontaneous functional regression in the rhesus macaque corpus luteum are identified, which in turn will further our understanding of primate luteolysis.

TECHNICAL COMMUNICATIONS:

Rami I. Aqeilan, John P. Hagan, Alain de Bruin, Maysoon Rawahneh, Zaidoun Salah, Eugenio Gaudio, Hasan Siddiqui, Stefano Volinia, Hansjuerg Alder, Jane B. Lian, Gary S. Stein, and Carlo M. Croce

Targeted Ablation of the WW Domain-Containing Oxidoreductase Tumor Suppressor Leads to Impaired Steroidogenesis
Endocrinology 2009 150: 1530-1535, doi:10.1210/en.2008-1087 [Abstract] [Full Text] [PDF]  
The Wwox tumor suppressor is an essential requirement in proper steroidogenesis.

THYROID -TRH -TSH:

Ailing Lu, Lily Ng, Michelle Ma, Benjamin Kefas, Terry F. Davies, Arturo Hernandez, Chi-Chao Chan, and Douglas Forrest

Retarded Developmental Expression and Patterning of Retinal Cone Opsins in Hypothyroid Mice
Endocrinology 2009 150: 1536-1544, doi:10.1210/en.2008-1092 [Abstract] [Full Text] [PDF]  
Hypothyroidism in mice retards expression of cone opsins, the photopigments required for color vision, highlighting the sensitivity of sensory systems to thyroid hormone.

Mami Nakahara, Yuji Nagayama, Ohki Saitoh, Rintaro Sogawa, Shigenobu Tone, and Norio Abiru

Expression of Immunoregulatory Molecules by Thyrocytes Protects Nonobese Diabetic-H2^h4 Mice from Developing Autoimmune Thyroiditis
Endocrinology 2009 150: 1545-1551, doi:10.1210/en.2008-0702 [Abstract] [Full Text] [PDF] [Supplemental Data]  
The feasibility of in situ expression of the immuno-regulatory molecules to prevent tissue destruction by autoimmune attack in organ-specific autoimmune diseases is discussed.

W. Edward Visser, Edith C. H. Friesema, and Theo J. Visser

Transport of Thyroxine and 3,3',5-Triiodothyronine in Human Umbilical Vein Endothelial Cells
Endocrinology 2009 150: 1552-1557, doi:10.1210/en.2008-0627 [Abstract] [Full Text] [PDF]  
The endothelium is the first barrier in the transport of thyroid hormone from plasma into tissues. Involvement of transporters is shown in this process.

TRANSLATIONAL HIGHLIGHTS FROM JCEM:

N. Ahmad Aziz, Hanno Pijl, Marijke Frölich, A. W. Maurits van der Graaf, Ferdinand Roelfsema, and Raymund A. C. Roos

Increased Hypothalamic-Pituitary-Adrenal Axis Activity in Huntington’s Disease
Endocrinology 2009 150: 1558 [Full Text] [PDF]  

Christiaan de Bruin, Alberto M. Pereira, Richard A. Feelders, Johannes A. Romijn, Ferdinand Roelfsema, Diane M. Sprij-Mooij, Maarten O. van Aken, Aart-Jan van der Lelij, Wouter W. de Herder, Steven W. J. Lamberts, and Leo J. Hofland

Coexpression of Dopamine and Somatostatin Receptor Subtypes in Corticotroph Adenomas
Endocrinology 2009 150: 1558-1559 [Full Text] [PDF]  

Cecilia Mattsson, Rebecca M. Reynolds, Kotryna Simonyte, Tommy Olsson, and Brian R. Walker

Combined Receptor Antagonist Stimulation of the Hypothalamic-Pituitary-Adrenal Axis Test Identifies Impaired Negative Feedback Sensitivity to Cortisol in Obese Men
Endocrinology 2009 150: 1559 [Full Text] [PDF]  

To see an article, click its [Full Text] link. To review many abstracts, check the boxes to the left of the titles you want, and click the 'Get All Checked Abstract(s)' button. To see one abstract at a time, click its [Abstract] link.