Cover The CNS regulation of body weight requires the acquisition and processing of complex information from external and internal cues that ultimately control food intake and energy expenditure. These neural systems include not only homeostatic regulators of energy balance such as the hypothalamus and brainstem, but also non-homeostatic systems, such as the cortex, basal ganglia, and limbic system, that are involved in learning, memory, reward, choice, and motivation. From the article in this issue by Obici et al., pages 2512–2517.