NEWS AND VIEWS:

Jill E. Schneider

If I Only Had a Whole Brain: The Importance of Extrahypothalamic Areas in the Energy Balance Equation
Endocrinology 2009 150: 5195-5198 doi:10.1210/en.2009-1203 [Full Text] [PDF]  

Suzanne M. Appleyard

Lighting Up Neuronal Pathways: The Development of a Novel Transgenic Rat that Identifies Fos-Activated Neurons Using a Red Fluorescent Protein
Endocrinology 2009 150: 5199-5201 doi:10.1210/en.2009-1234 [Full Text] [PDF]  

Debbie C. Thurmond

Insulin-Regulated Glucagon-Like Peptide-1 Release from L Cells: Actin’ Out
Endocrinology 2009 150: 5202-5204 doi:10.1210/en.2009-1178 [Full Text] [PDF]  

Sean M. Davidson and Derek M. Yellon

Urocortin: A Few Inflammatory Remarks
Endocrinology 2009 150: 5205-5207 doi:10.1210/en.2009-1179 [Full Text] [PDF]  

CANCER-ONCOGENES:

Brooke S. Middlebrook, Karen Eldin, Xiaohui Li, Sujatha Shivasankaran, and Stephanie A. Pangas

Smad1-Smad5 Ovarian Conditional Knockout Mice Develop a Disease Profile Similar to the Juvenile Form of Human Granulosa Cell Tumors
Endocrinology 2009 150: 5208-5217 , doi:10.1210/en.2009-0644 [Abstract] [Full Text] [PDF] [Supplemental Data]  
Histologic and hormonal analysis of the phenotype of mice with genetic disruption of the bone morphogenetic protein and anti-Müllerian hormone canonical transcription factors demonstrate that this mouse model develops a disease resembling human juvenile granulosa cell tumor.

DIABETES-INSULIN-GLUCAGON-GASTROINTESTINAL:

Marianne Böni-Schnetzler, Simone Boller, Sarah Debray, Karim Bouzakri, Daniel T. Meier, Richard Prazak, Julie Kerr-Conte, Francois Pattou, Jan A. Ehses, Frans C. Schuit, and Marc Y. Donath

Free Fatty Acids Induce a Proinflammatory Response in Islets via the Abundantly Expressed Interleukin-1 Receptor I
Endocrinology 2009 150: 5218-5229 , doi:10.1210/en.2009-0543 [Abstract] [Full Text] [PDF] [Supplemental Data]  
Free fatty acids, like glucose, can induce an inflammatory response in human islets.

Mari Suzuki, Rieko Setsuie, and Keiji Wada

Ubiquitin Carboxyl-Terminal Hydrolase L3 Promotes Insulin Signaling and Adipogenesis
Endocrinology 2009 150: 5230-5239 , doi:10.1210/en.2009-0332 [Abstract] [Full Text] [PDF]  
A de-ubiquitinating enzyme, UCH-L3, promotes adipogenesis by enhancing insulin signaling in a hydrolase activity-dependent manner.

Olga V. Danilova, Albert K. Tai, Deanna A. Mele, Martin Beinborn, Andrew B. Leiter, Andrew S. Greenberg, James W. Perfield, II, Jason DeFuria, Praful S. Singru, Ronald M. Lechan, and Brigitte T. Huber

Neurogenin 3-Specific Dipeptidyl Peptidase-2 Deficiency Causes Impaired Glucose Tolerance, Insulin Resistance, and Visceral Obesity
Endocrinology 2009 150: 5240-5248 , doi:10.1210/en.2009-0386 [Abstract] [Full Text] [PDF]  
DPP2 enzyme activity is essential for maintaining glucose homeostasis, preventing hyperinsulinemia and obesity.

Gareth E. Lim, Molie Xu, Jane Sun, Tianru Jin, and Patricia L. Brubaker

The Rho Guanosine 5'-Triphosphatase, Cell Division Cycle 42, Is Required for Insulin-Induced Actin Remodeling and Glucagon-Like Peptide-1 Secretion in the Intestinal Endocrine L Cell
Endocrinology 2009 150: 5249-5261 , doi:10.1210/en.2009-0508 [Abstract] [Full Text] [PDF] [Supplemental Data]  
Insulin-induced glucagon-like peptide-1 secretion from the intestinal L cell is regulated through Cdc42-mediated activation of PAK1 and MEK1/2-ERK/1/2 and reorganization of the actin cytoskeleton.

Tayeba Khan, Mark P. Hamilton, Dorothy I. Mundy, Streamson C. Chua, and Philipp E. Scherer

Impact of Simvastatin on Adipose Tissue: Pleiotropic Effects in Vivo
Endocrinology 2009 150: 5262-5272 , doi:10.1210/en.2009-0603 [Abstract] [Full Text] [PDF] [Supplemental Data]  
Inhibition of cholesterol biosynthesis by statins exerts profound effects on adipocytes in vitro and in vivo, altering the ultrastructure of the plasma membrane, reducing release of high molecular weight adiponectin, and suppressing inflammation but without negatively affecting whole-body metabolism.

Viktor R. Drel, Weizheng Xu, Jie Zhang, Ivan A. Pavlov, Hanna Shevalye, Barbara Slusher, and Irina G. Obrosova

Poly(Adenosine 5'-Diphosphate-Ribose) Polymerase Inhibition Counteracts Multiple Manifestations of Experimental Type 1 Diabetic Nephropathy
Endocrinology 2009 150: 5273-5283 , doi:10.1210/en.2009-0628 [Abstract] [Full Text] [PDF]  
Evidence is provided of the important role for poly(ADP-ribose) polymerase activation in the pathogenesis of type 1 diabetic nephropathy, thus justifying the rationale for development and further studies of poly(ADP-ribose) polymerase inhibitors.

Zhuoxian Meng, Jinghuan Lv, Ying Luo, Yan Lin, Yunxia Zhu, Jia Nie, Tao Yang, Yujie Sun, and Xiao Han

Forkhead Box O1/Pancreatic and Duodenal Homeobox 1 Intracellular Translocation Is Regulated by c-Jun N-Terminal Kinase and Involved in Prostaglandin E₂-Induced Pancreatic β-Cell Dysfunction
Endocrinology 2009 150: 5284-5293 , doi:10.1210/en.2009-0671 [Abstract] [Full Text] [PDF]  
Activation of the JNK pathway is responsible for prostaglandin E₂-mediated reciprocal subcellular translocation of forkhead box O1/pancreatic and duodenal homeobox 1, and impaired glucose-stimulated insulin secretion in pancreatic cells.

Bhumsoo Kim, Carey Backus, SangSu Oh, John M. Hayes, and Eva L. Feldman

Increased Tau Phosphorylation and Cleavage in Mouse Models of Type 1 and Type 2 Diabetes
Endocrinology 2009 150: 5294-5301 , doi:10.1210/en.2009-0695 [Abstract] [Full Text] [PDF] [Supplemental Data]  
Alzheimer’s disease-like tau modification caused by insulin dysfunction and hyperglycemia may contribute to the increased incidence of Alzheimer’s disease in diabetes.

Sarah A. Evans, Manuel Doblado, Maggie M. Chi, John A. Corbett, and Kelle H. Moley

Facilitative Glucose Transporter 9 Expression Affects Glucose Sensing in Pancreatic β-Cells
Endocrinology 2009 150: 5302-5310 , doi:10.1210/en.2009-0747 [Abstract] [Full Text] [PDF]  
The expression of glucose transporters GLUT9a and GLUT9b in murine and human β-cells is confirmed, and the results suggest that GLUT9 may participate in glucose sensing in β-cells.

Claudio Sartori, Pierre Dessen, Caroline Mathieu, Anita Monney, Jonathan Bloch, Pascal Nicod, Urs Scherrer, and Hervé Duplain

Melatonin Improves Glucose Homeostasis and Endothelial Vascular Function in High-Fat Diet-Fed Insulin-Resistant Mice
Endocrinology 2009 150: 5311-5317 , doi:10.1210/en.2009-0425 [Abstract] [Full Text] [PDF]  
In a diet-induced model of insulin resistance, treatment with melatonin significantly improves insulin sensitivity and vascular function in mice.

Jean-François Landrier, Erwan Gouranton, Claire El Yazidi, Christiane Malezet, Patrick Balaguer, Patrick Borel, and Marie-Josèphe Amiot

Adiponectin Expression Is Induced by Vitamin E via a Peroxisome Proliferator-Activated Receptor -Dependent Mechanism
Endocrinology 2009 150: 5318-5325 , doi:10.1210/en.2009-0506 [Abstract] [Full Text] [PDF]  
Vitamin E up-regulates adiponectin expression via a mechanism that implicates PPAR- together with its endogenous ligand 15d-PGJ2.

Giorgio Ramadori, Laurent Gautron, Teppei Fujikawa, Claudia R. Vianna, Joel K. Elmquist, and Roberto Coppari

Central Administration of Resveratrol Improves Diet-Induced Diabetes
Endocrinology 2009 150: 5326-5333 , doi:10.1210/en.2009-0528 [Abstract] [Full Text] [PDF] [Supplemental Data]  
Oral delivery of the natural pholyphenolic compound resveratrol exerts anti-diabetic actions; these results show that these effects are in part mediated by the brain.

Bo Hellman, Albert Salehi, Erik Gylfe, Heléne Dansk, and Eva Grapengiesser

Glucose Generates Coincident Insulin and Somatostatin Pulses and Antisynchronous Glucagon Pulses from Human Pancreatic Islets
Endocrinology 2009 150: 5334-5340 , doi:10.1210/en.2009-0600 [Abstract] [Full Text] [PDF]  
Opposed cycles of insulin and glucagon release facilitate the islet control of hepatic glucose production in humans.

ENERGY BALANCE-OBESITY:

J. Sánchez, A. Palou, and C. Picó

Response to Carbohydrate and Fat Refeeding in the Expression of Genes Involved in Nutrient Partitioning and Metabolism: Striking Effects on Fibroblast Growth Factor-21 Induction
Endocrinology 2009 150: 5341-5350 , doi:10.1210/en.2009-0466 [Abstract] [Full Text] [PDF]  
The intake of carbohydrates or fat results in marked differences in gene expression that can explain diet-associated differences in fuel handling and partitioning between tissues.

Karolina P. Skibicka and Harvey J. Grill

Hypothalamic and Hindbrain Melanocortin Receptors Contribute to the Feeding, Thermogenic, and Cardiovascular Action of Melanocortins
Endocrinology 2009 150: 5351-5361 , doi:10.1210/en.2009-0804 [Abstract] [Full Text] [PDF] [Supplemental Data]  
Food intake and energy expenditure effects of central melanocortin stimulation are driven by anatomically distributed melanocortin receptor expressing neurons.

Joshua P. Thaler, Sun Ju Choi, Mini P. Sajan, Kayoko Ogimoto, Hong T. Nguyen, Miles Matsen, Stephen C. Benoit, Brent E. Wisse, Robert V. Farese, and Michael W. Schwartz

Atypical Protein Kinase C Activity in the Hypothalamus Is Required for Lipopolysaccharide-Mediated Sickness Responses
Endocrinology 2009 150: 5362-5372 , doi:10.1210/en.2009-0509 [Abstract] [Full Text] [PDF]  
Inhibition of atypical protein kinase C activity in the brain prevents fever and anorexia induced by lipopolysaccharide.

Gabriele Tiller, Pamela Fischer-Posovszky, Helmut Laumen, Andreas Finck, Thomas Skurk, Michaela Keuper, Ulrich Brinkmann, Martin Wabitsch, Dieter Link, and Hans Hauner

Effects of TWEAK (TNF Superfamily Member 12) on Differentiation, Metabolism, and Secretory Function of Human Primary Preadipocytes and Adipocytes
Endocrinology 2009 150: 5373-5383 , doi:10.1210/en.2009-0488 [Abstract] [Full Text] [PDF] [Supplemental Data]  
TWEAK and the corresponding agonistic antibody have the potential to prevent adipose tissue growth without adversely influencing metabolism or pro-inflammatory cytokine secretion in adipose tissue.

GENERAL ENDOCRINOLOGY:

Qiaohua Kang and Anping Chen

Curcumin Inhibits srebp-2 Expression in Activated Hepatic Stellate Cells in Vitro by Reducing the Activity of Specificity Protein-1
Endocrinology 2009 150: 5384-5394 , doi:10.1210/en.2009-0517 [Abstract] [Full Text] [PDF]  
The activation of PPAR by curcumin results in the suppression of gene expression of SP-1 and the reduction in its trans-activation activity, leading to the repression of gene expression of sterol regulatory element binding protein-2 in activated hepatic stellate cells.

Dawit A. P. Gonçalves, Eduardo C. Lira, Amanda M. Baviera, Peirang Cao, Neusa M. Zanon, Zoltan Arany, Nathalie Bedard, Preeti Tanksale, Simon S. Wing, Stewart H. Lecker, Isis C. Kettelhut, and Luiz C. C. Navegantes

Mechanisms Involved in 3',5'-Cyclic Adenosine Monophosphate-Mediated Inhibition of the Ubiquitin-Proteasome System in Skeletal Muscle
Endocrinology 2009 150: 5395-5404 , doi:10.1210/en.2009-0428 [Abstract] [Full Text] [PDF]  
The cAMP increase induced by stimulation of β₂-adrenoceptors is possibly the mechanism by which clenbuterol, via Akt/Foxo3 signaling, attenuate the fasting-induced muscle atrophy.

Kristin Happ Molitoris, Armina A. Kazi, and Robert D. Koos

Inhibition of Oxygen-Induced Hypoxia-Inducible Factor-1 Degradation Unmasks Estradiol Induction of Vascular Endothelial Growth Factor Expression in ECC-1 Cancer Cells in Vitro
Endocrinology 2009 150: 5405-5414 , doi:10.1210/en.2009-0884 [Abstract] [Full Text] [PDF] [Supplemental Data]  
Prevention of oxygen-induced degradation of the transcription factor HIF-1 in cultured endometrial cancer cells by treatment with CoCl₂ restores strong 17β-estradiol induction of VEGF gene expression, as occurs in normal endometrial epithelial cells in vivo.

Yukiko Ogino, Hironori Katoh, Shigehiro Kuraku, and Gen Yamada

Evolutionary History and Functional Characterization of Androgen Receptor Genes in Jawed Vertebrates
Endocrinology 2009 150: 5415-5427 , doi:10.1210/en.2009-0523 [Abstract] [Full Text] [PDF] [Supplemental Data]  
The common ancestor of all extant-jawed vertebrate contains the most ancient type of androgen receptor (AR), and teleosts have two functionally different ARs duplicated with teleost-specific genome duplication.

Elizabeth L. Cureton, Alexander Q. Ereso, Gregory P. Victorino, Brian Curran, Daniel P. Poole, Min Liao, Alden H. Harken, and Aditi Bhargava

Local Secretion of Urocortin 1 Promotes Microvascular Permeability during Lipopolysaccharide-Induced Inflammation
Endocrinology 2009 150: 5428-5437 , doi:10.1210/en.2009-0489 [Abstract] [Full Text] [PDF] [Supplemental Data]  
During inflammatory insults, locally secreted urocotin 1 is pivotal in regulating fluid and macromolecular leak from mesenteric venules.

Barbara Costa, Stefano Pini, Pamela Gabelloni, Eleonora Da Pozzo, Marianna Abelli, Lisa Lari, Matteo Preve, Antonio Lucacchini, Giovanni B. Cassano, and Claudia Martini

The Spontaneous Ala147Thr Amino Acid Substitution within the Translocator Protein Influences Pregnenolone Production in Lymphomonocytes of Healthy Individuals
Endocrinology 2009 150: 5438-5445 , doi:10.1210/en.2009-0752 [Abstract] [Full Text] [PDF]  
The Ala147Thr single nucleotide polymorphism within TSPO affects the production of first metabolite of the steroidogenesis pathway, pregnenolone, and is associated with plasma low density lipoproteins levels.

Martha E. Cruz-Soto, Gabriela Cosío, Michael C. Jeziorski, Víctor Vargas-Barroso, Manuel B. Aguilar, Alfonso Cárabez, Peter Berger, Paul Saftig, Edith Arnold, Stéphanie Thebault, Gonzalo Martínez de la Escalera, and Carmen Clapp

Cathepsin D Is the Primary Protease for the Generation of Adenohypophyseal Vasoinhibins: Cleavage Occurs within the Prolactin Secretory Granules
Endocrinology 2009 150: 5446-5454 , doi:10.1210/en.2009-0390 [Abstract] [Full Text] [PDF]  
Vasoinhibins, antiangiogenic fragments of prolactin, are endogenously generated by cathepsin D within the anterior pituitary gland.

Hui You and Suzanne G. Laychock

Atrial Natriuretic Peptide Promotes Pancreatic Islet β-Cell Growth and Akt/Foxo1a/Cyclin D2 Signaling
Endocrinology 2009 150: 5455-5465 , doi:10.1210/en.2009-0468 [Abstract] [Full Text] [PDF]  
Atrial natriuretic peptide initiates a signal transduction mechanism that modulates the onset of mitogenesis in pancreatic β-cells through cGMP/PI3K/Akt/Foxo1a/cyclin D2 signaling pathway.

GLUCOCORTICOIDS-CRH-ACTH-ADRENAL:

Thorsten Braun, Shaofu Li, Deborah M. Sloboda, Wei Li, Melanie C. Audette, Timothy J. M. Moss, Stephen G. Matthews, Graeme Polglase, Ilias Nitsos, John P. Newnham, and John R. G. Challis

Effects of Maternal Dexamethasone Treatment in Early Pregnancy on Pituitary-Adrenal Axis in Fetal Sheep
Endocrinology 2009 150: 5466-5477 , doi:10.1210/en.2009-0086 [Abstract] [Full Text] [PDF]  
Exposure to high levels of bioactive glucocorticoids in the first trimester of pregnancy has sex-specific effects on fetal adrenal steroidogenic enzyme mRNA levels and modifies placental 11βHSD2 mRNA levels in the sheep.

GROWTH HORMONE-SOMATOSTATIN-GRH:

Jane S. Titterington, Sergiy Sukhanov, Yusuke Higashi, Charlotte Vaughn, Cyril Bowers, and Patrice Delafontaine

Growth Hormone-Releasing Peptide-2 Suppresses Vascular Oxidative Stress in ApoE^–/– Mice But Does Not Reduce Atherosclerosis
Endocrinology 2009 150: 5478-5487 , doi:10.1210/en.2009-0283 [Abstract] [Full Text] [PDF] [Supplemental Data]  
GHRP-2 has beneficial effects on vascular cells in vitro and reduces oxidative stress in vivo but does not reduce atherosclerosis in a mouse model.

NEUROENDOCRINOLOGY:

Kathryn Backholer, Jeremy Smith, and Iain J. Clarke

Melanocortins May Stimulate Reproduction by Activating Orexin Neurons in the Dorsomedial Hypothalamus and Kisspeptin Neurons in the Preoptic Area of the Ewe
Endocrinology 2009 150: 5488-5497 , doi:10.1210/en.2009-0604 [Abstract] [Full Text] [PDF]  
Infusion of a melanocortin agonist increases kisspeptin gene expression in the preoptic area and stimulates LH secretion in the luteal phase of the estrous cycle.

Weiling Yin, Di Wu, Megan L. Noel, and Andrea C. Gore

Gonadotropin-Releasing Hormone Neuroterminals and Their Microenvironment in the Median Eminence: Effects of Aging and Estradiol Treatment
Endocrinology 2009 150: 5498-5508 , doi:10.1210/en.2009-0679 [Abstract] [Full Text] [PDF]  
GnRH neuroterminals undergo substantial changes in their ultrastructural properties, and in their neural-glial relationships, during reproductive aging.

Philippe Ciofi, Maurice Garret, Olivier Lapirot, Pierrette Lafon, Anne Loyens, Vincent Prévot, and Jon E. Levine

Brain-Endocrine Interactions: A Microvascular Route in the Mediobasal Hypothalamus
Endocrinology 2009 150: 5509-5519 , doi:10.1210/en.2009-0584 [Abstract] [Full Text] [PDF]  
Phenotypically permeable capillary vessels are abundant in a discrete hypothalamic region targeted by peripheral hormones, the arcuate nucleus.

Dieter Müller, Balanes Hida, Gabriela Guidone, Robert C. Speth, Tatyana V. Michurina, Grigori Enikolopov, and Ralf Middendorff

Expression of Guanylyl Cyclase (GC)-A and GC-B during Brain Development: Evidence for a Role of GC-B in Perinatal Neurogenesis
Endocrinology 2009 150: 5520-5529 , doi:10.1210/en.2009-0490 [Abstract] [Full Text] [PDF] [Supplemental Data]  
Guanylyl cyclase-B (GC-B) marks early neuronal progeny of nestin-expressing cells and suggests that CNP/GC-B/cGMP signaling controls perinatal stages of brain maturation.

J. T. Smith, Q. Li, A. Pereira, and I. J. Clarke

Kisspeptin Neurons in the Ovine Arcuate Nucleus and Preoptic Area Are Involved in the Preovulatory Luteinizing Hormone Surge
Endocrinology 2009 150: 5530-5538 , doi:10.1210/en.2009-0712 [Abstract] [Full Text] [PDF]  
Estradiol stimulates the activation of kisspeptin neurons located in the arcuate nucleus of the brain, which leads to the estradiol positive feedback preovulatory GnRH/LH surge in the ewe.

Rebecca L. Cunningham, Andrea Giuffrida, and James L. Roberts

Androgens Induce Dopaminergic Neurotoxicity via Caspase-3-Dependent Activation of Protein Kinase C
Endocrinology 2009 150: 5539-5548 , doi:10.1210/en.2009-0640 [Abstract] [Full Text] [PDF]  
Androgens induce apoptosis in a dopaminergic cell line via caspase-3-dependent activation of PKC.

Ika P. Sari, Alexandra Rao, Jeremy T. Smith, Alan J. Tilbrook, and Iain J. Clarke

Effect of RF-Amide-Related Peptide-3 on Luteinizing Hormone and Follicle-Stimulating Hormone Synthesis and Secretion in Ovine Pituitary Gonadotropes
Endocrinology 2009 150: 5549-5556 , doi:10.1210/en.2009-0775 [Abstract] [Full Text] [PDF]  
RFRP-3 (gonadotropin inhibitory hormone) acts directly on GnRH-stimulated ovine gonadotropes to reduce the expression of LH-β and FSH-β genes.

RENAL-CARDIAC-VASCULAR:

Jiqian Huang and Helmy M. Siragy

Glucose Promotes the Production of Interleukine-1β and Cyclooxygenase-2 in Mesangial Cells via Enhanced (Pro)Renin Receptor Expression
Endocrinology 2009 150: 5557-5565 , doi:10.1210/en.2009-0442 [Abstract] [Full Text] [PDF]  
Hyperglycemia and COX2 stimulates (Pro)renin receptor expression and its inflammatory mediators, suggesting a positive feedback loop involving inflammation and this receptor.

REPRODUCTION - DEVELOPMENT:

Noriko Kobayashi, Makoto Orisaka, Mingju Cao, Fumikazu Kotsuji, Arthur Leader, Noriaki Sakuragi, and Benjamin K. Tsang

Growth Differentiation Factor-9 Mediates Follicle-Stimulating Hormone-Thyroid Hormone Interaction in the Regulation of Rat Preantral Follicular Development
Endocrinology 2009 150: 5566-5574 , doi:10.1210/en.2009-0262 [Abstract] [Full Text] [PDF]  
Thyroid hormone promotes FSH-induced preantral follicular growth through up-regulation of FSH receptor, a mechanism dependent on the expression and action of oocyte-derived GDF-9.

D. B. Martinez-Arguelles, M. Culty, B. R. Zirkin, and V. Papadopoulos

In Utero Exposure to Di-(2-Ethylhexyl) Phthalate Decreases Mineralocorticoid Receptor Expression in the Adult Testis
Endocrinology 2009 150: 5575-5585 , doi:10.1210/en.2009-0847 [Abstract] [Full Text] [PDF] [Supplemental Data]  
Exposure to plasticizer DEHP during pregnancy reduces circulating testosterone levels in the adult offspring by decreasing the expression of mineralocorticoid receptor in testicular Leydig cells.

Li Zhu, Nadine C. Santos, and Kwan Hee Kim

Small Ubiquitin-Like Modifier-2 Modification of Retinoic Acid Receptor- Regulates Its Subcellular Localization and Transcriptional Activity
Endocrinology 2009 150: 5586-5595 , doi:10.1210/en.2009-0868 [Abstract] [Full Text] [PDF]  
SUMO-2 modification of retinoic acid receptor (RARA) regulates the function of RARA.

HaiBin Kuang, Qi Chen, Ying Zhang, Li Zhang, HongYing Peng, LiNa Ning, Yujing Cao, and EnKui Duan

The Cytokine Gene CXCL14 Restricts Human Trophoblast Cell Invasion by Suppressing Gelatinase Activity
Endocrinology 2009 150: 5596-5605 , doi:10.1210/en.2009-0570 [Abstract] [Full Text] [PDF] [Supplemental Data]  
CXCL14 expressed at maternal-fetal interface during early pregnancy inhibits human trophoblast cell invasion by suppressing gelatinase activity, an autocrine/paracrine process mediated through binding to its putative receptor(s) on trophoblast cells.

Liu Min, Toshihiko Yanase, Tomoko Tanaka, WuQiang Fan, Masatoshi Nomura, Hisaya Kawate, Taijiro Okabe, Ryoichi Takayanagi, and Hajime Nawata

A Novel Synthetic Androgen Receptor Ligand, S42, Works as a Selective Androgen Receptor Modulator and Possesses Metabolic Effects with Little Impact on the Prostate
Endocrinology 2009 150: 5606-5616 , doi:10.1210/en.2009-0405 [Abstract] [Full Text] [PDF] [Supplemental Data]  
S42 is an AR agonist, at least in muscle, and acts as an AR antagonist in the prostate, pituitary gland, liver, and adipose tissue.

Elisa K. Tyson, Roger Smith, and Mark Read

Evidence that Corticotropin-Releasing Hormone Modulates Myometrial Contractility during Human Pregnancy
Endocrinology 2009 150: 5617-5625 , doi:10.1210/en.2009-0348 [Abstract] [Full Text] [PDF]  
Use of corticotrophin-releasing hormone (CRH) on human pregnant myometrial tissue provides functional evidence that CRH, produced in large quantities by the placenta, modulates the contractile state of the pregnant myometrium; CRH causes relaxation of pre-term and term myometrial samples, and CRH-induced relaxation is enhanced in the presence of progesterone and phosphodiesterase inhibition.

TECHNICAL COMMUNICATIONS:

Tamar Alon, Ligang Zhou, Cristian A. Pérez, Alastair S. Garfield, Jeffrey M. Friedman, and Lora K. Heisler

Transgenic Mice Expressing Green Fluorescent Protein under the Control of the Corticotropin-Releasing Hormone Promoter
Endocrinology 2009 150: 5626-5632 , doi:10.1210/en.2009-0881 [Abstract] [Full Text] [PDF] [Supplemental Data]  
A transgenic mouse line expressing green fluorescent protein under the control of the corticotropin-releasing hormone promoter (CRH-GFP) was generated to facilitate the investigation of endogenous CRH expression and function.

Hiroaki Fujihara, Yoichi Ueta, Hitoshi Suzuki, Akiko Katoh, Toyoaki Ohbuchi, Hiroki Otsubo, Govindan Dayanithi, and David Murphy

Robust Up-Regulation of Nuclear Red Fluorescent-Tagged Fos Marks Neuronal Activation in Green Fluorescent Vasopressin Neurons after Osmotic Stimulation in a Double-Transgenic Rat
Endocrinology 2009 150: 5633-5638 , doi:10.1210/en.2009-0796 [Abstract] [Full Text] [PDF]  
Transgenic rats were generated that express a c-fos-mRFP1 fusion gene that illuminates activated neurons by virtue of robust fluorescence.

THYROID-TRH-TSH:

Lars P. Klieverik, Claudia P. Coomans, Erik Endert, Hans P. Sauerwein, Louis M. Havekes, Peter J. Voshol, Patrick C. N. Rensen, Johannes A. Romijn, Andries Kalsbeek, and Eric Fliers

Thyroid Hormone Effects on Whole-Body Energy Homeostasis and Tissue-Specific Fatty Acid Uptake in Vivo
Endocrinology 2009 150: 5639-5648 , doi:10.1210/en.2009-0297 [Abstract] [Full Text] [PDF] [Supplemental Data]  
Thyroid hormone status determines whole body energy expenditure independently of physical activity; in addition, it determines tissue-specific changes in triglyceride-derived fatty acid uptake that are in accordance with the hyper- and hypometabolic states induced by thyrotoxicosis and hypothyroidism, respectively.

TRANSLATIONAL HIGHLIGHTS FROM JCEM:

Laura A. Young, Michelle B. Neiss, Mary H. Samuels, Charles E. Roselli, and Jeri S. Janowsky

Cognition Is Not Modified by Large but Temporary Changes in Sex Hormones in Men
Endocrinology 2009 150: 5649-5650 [Full Text] [PDF]  

Jonathan T. Tan, Daniel P. K. Ng, Siti Nurbaya, Sandra Ye, Xiu Li Lim, Helen Leong, Lin Tze Seet, Wei Fong Siew, Winston Kon, Tien Yin Wong, Seang Mei Saw, Tin Aung, Kee Seng Chia, Jeannette Lee, Suok Kai Chew, Mark Seielstad, and E. Shyong Tai

Polymorphisms Identified through Genome-Wide Association Studies and Their Associations with Type 2 Diabetes in Chinese, Malays, and Asian-Indians in Singapore
Endocrinology 2009 150: 5649-a [Full Text] [PDF]  

Paul Welsh, Eliana Polisecki, Michele Robertson, Sabine Jahn, Brendan M. Buckley, Anton J. M. de Craen, Ian Ford, J. Wouter Jukema, Peter W. Macfarlane, Chris J. Packard, David J. Stott, Rudi G. J. Westendorp, James Shepherd, Aroon D. Hingorani, George Davey Smith, Ernst Schaefer, and Naveed Sattar

Unraveling the Directional Link between Adiposity and Inflammation: A Bidirectional Mendelian Randomization Approach
Endocrinology 2009 150: 5650-5651 [Full Text] [PDF]  

Thor Ueland, Stine L. Fougner, Kristin Godang, Tove Lekva, Leon J. Schurgers, Hanne Scholz, Bente Halvorsen, Thomas Schreiner, Pål Aukrust, and Jens Bollerslev

Associations between Body Composition, Circulating Interleukin-1 Receptor Antagonist, Osteocalcin, and Insulin Metabolism in Active Acromegaly
Endocrinology 2009 150: 5650-a [Full Text] [PDF]  

Guenther Boden, Matthew Silviera, Brian Smith, Peter Cheung, and Carol Homko

Acute Tissue Injury Caused by Subcutaneous Fat Biopsies Produces Endoplasmic Reticulum Stress
Endocrinology 2009 150: 5651 [Full Text] [PDF]  

ANNOUNCEMENTS AND RESOURCES:

Erratum
Endocrinology 2009 150: 5652 [Full Text] [PDF]  

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