NEWS AND VIEWS:

Colleen M. Novak

Neuromedin S and U
Endocrinology 2009 150: 2985-2987 doi:10.1210/en.2009-0448 [Full Text] [PDF]  

John P. Lydon and Dean P. Edwards

Finally! A Model for Progesterone Receptor Action in Normal Human Breast
Endocrinology 2009 150: 2988-2990 doi:10.1210/en.2009-0383 [Full Text] [PDF]  

M. L. Seney and N. G. Forger

Sexual Differentiation of the Nervous System: Where the Action Is
Endocrinology 2009 150: 2991-2993 doi:10.1210/en.2009-0388 [Full Text] [PDF]  

Rohit N. Kulkarni

Uncoupling Modifier Genes from Uncoupling Protein 2 in Pancreatic β-Cells
Endocrinology 2009 150: 2994-2996 doi:10.1210/en.2009-0440 [Full Text] [PDF]  

MINIREVIEWS:

Diana L. Williams

Minireview: Finding the Sweet Spot: Peripheral Versus Central Glucagon-Like Peptide 1 Action in Feeding and Glucose Homeostasis
Endocrinology 2009 150: 2997-3001 , doi:10.1210/en.2009-0220 [Abstract] [Full Text] [PDF]  
This review summarizes the evidence for involvement of peripheral and brain glucagon-like peptide 1 (GLP-1) in food intake regulation and glucose homeostasis, and proposes a model for the coordinated actions of GLP-1 at multiple sites.

CALCIUM-REGULATING HORMONES:

Michael P. Greenwood, Gert Flik, Graham F. Wagner, and Richard J. Balment

The Corpuscles of Stannius, Calcium-Sensing Receptor, and Stanniocalcin: Responses to Calcimimetics and Physiological Challenges
Endocrinology 2009 150: 3002-3010 , doi:10.1210/en.2008-1758 [Abstract] [Full Text] [PDF]  
Molecular and functional analyses confirm that the calcium-sensing receptor is a key consistent component of calcium regulatory hormone systems from fish to mammals.

DIABETES-INSULIN-GLUCAGON-GASTROINTESTINAL:

Youcai Tang, Shizhong Zheng, and Anping Chen

Curcumin Eliminates Leptin’s Effects on Hepatic Stellate Cell Activation via Interrupting Leptin Signaling
Endocrinology 2009 150: 3011-3020 , doi:10.1210/en.2008-1601 [Abstract] [Full Text] [PDF]  
Curcumin eliminates the stimulatory impact of leptin on the activation of hepatic satellite cells by interrupting leptin signaling and attenuating leptin-induced oxidative stress.

Stephanie R. Thorn, Timothy R. H. Regnault, Laura D. Brown, Paul J. Rozance, Jane Keng, Michael Roper, Randall B. Wilkening, William W. Hay, Jr., and Jacob E. Friedman

Intrauterine Growth Restriction Increases Fetal Hepatic Gluconeogenic Capacity and Reduces Messenger Ribonucleic Acid Translation Initiation and Nutrient Sensing in Fetal Liver and Skeletal Muscle
Endocrinology 2009 150: 3021-3030 , doi:10.1210/en.2008-1789 [Abstract] [Full Text] [PDF] [Supplemental Data]  
Intrauterine growth restriction is associated with changes in hormone and nutrient sensing pathways and increased gluconeogenesis which are likely important mechanisms in fetal programming of adult metabolic disease.

Tiane Dai, Mina Patel-Chamberlin, Rama Natarajan, Ivan Todorov, Jun Ma, Janine LaPage, Lynetta Phillips, Cynthia C. Nast, Diana Becerra, Peter Chuang, Lili Tong, Jacqueline de Belleroche, Dominic J. Wells, Ying Wang, and Sharon G. Adler

Heat Shock Protein 27 Overexpression Mitigates Cytokine-Induced Islet Apoptosis and Streptozotocin-Induced Diabetes
Endocrinology 2009 150: 3031-3039 , doi:10.1210/en.2008-0732 [Abstract] [Full Text] [PDF]  
HSP27 overexpression protects islets from cytokine-induced injury and streptozotocin-induced diabetes in vitro and in vivo, respectively, through a mechanism that is likely to involve modulation of NF-B signaling.

Jingbo Pi, Yushi Bai, Kiefer W. Daniel, Dianxin Liu, Otis Lyght, Diane Edelstein, Michael Brownlee, Barbara E. Corkey, and Sheila Collins

Persistent Oxidative Stress Due to Absence of Uncoupling Protein 2 Associated with Impaired Pancreatic β-Cell Function
Endocrinology 2009 150: 3040-3048 , doi:10.1210/en.2008-1642 [Abstract] [Full Text] [PDF] [Supplemental Data]  
Genetic background of mice lacking UCP2 has major influence on their results and interpretation; results show oxidative stress and impaired insulin secretion in all backcrossed strains.

Jörgen Borg, Cecilia Klint, Nils Wierup, Kristoffer Ström, Sara Larsson, Frank Sundler, Roberto Lupi, Piero Marchetti, Guoheng Xu, Alan Kimmel, Constantine Londos, and Cecilia Holm

Perilipin Is Present in Islets of Langerhans and Protects against Lipotoxicity When Overexpressed in the β-Cell Line INS-1
Endocrinology 2009 150: 3049-3057 , doi:10.1210/en.2008-0913 [Abstract] [Full Text] [PDF]  
Perilipin is expressed in both clonal and primary β-cells and its overexpression in INS-1 cells protects against lipotoxicity by decreasing lipolysis and promoting triglyceride storage.

Si-wu Peng, Lin-yun Zhu, Miao Chen, Mei Zhang, Di-zheng Li, Yu-cai Fu, Shen-ren Chen, and Chi-ju Wei

Heterogeneity in Mitotic Activity and Telomere Length Implies an Important Role of Young Islets in the Maintenance of Islet Mass in the Adult Pancreas
Endocrinology 2009 150: 3058-3066 , doi:10.1210/en.2008-1731 [Abstract] [Full Text] [PDF]  
Young islets in the adult pancreas have longer telomeres and higher proliferative abilities.

Charlotta S. Olofsson, Joakim Håkansson, Albert Salehi, Martin Bengtsson, Juris Galvanovskis, Chris Partridge, Maria SörhedeWinzell, Xiaojie Xian, Lena Eliasson, Ingmar Lundquist, Henrik Semb, and Patrik Rorsman

Impaired Insulin Exocytosis in Neural Cell Adhesion Molecule^–/– Mice Due to Defective Reorganization of the Submembrane F-Actin Network
Endocrinology 2009 150: 3067-3075 , doi:10.1210/en.2008-0475 [Abstract] [Full Text] [PDF] [Supplemental Data]  
Ablation of neural cell adhesion molecule (NCAM) resulted in a dense submembrane actin network in pancreatic islets and associated with abnormal glucose regulation of insulin and glucagon secretion.

ENERGY BALANCE-OBESITY:

Ren Zhang, Eleftheria Maratos-Flier, and Jeffrey S. Flier

Reduced Adiposity and High-Fat Diet-Induced Adipose Inflammation in Mice Deficient for Phosphodiesterase 4B
Endocrinology 2009 150: 3076-3082 , doi:10.1210/en.2009-0108 [Abstract] [Full Text] [PDF] [Supplemental Data]  
Mice deficient in phosphodiesterase 4B had reduced adiposity and high fat diet-induced adipose inflammation.

Eran Elinav, Leonora Niv-Spector, Meirav Katz, Tulin O. Price, Mohammed Ali, Michal Yacobovitz, Gili Solomon, Shay Reicher, Jessica L. Lynch, Zamir Halpern, William A. Banks, and Arieh Gertler

Pegylated Leptin Antagonist Is a Potent Orexigenic Agent: Preparation and Mechanism of Activity
Endocrinology 2009 150: 3083-3091 , doi:10.1210/en.2008-1706 [Abstract] [Full Text] [PDF] [Supplemental Data]  
Pegylated leptin antagonist induces reversible leptin deficiency by inhibiting leptin transport across the brain blood barrier.

Gilbert L. Hendricks, III, Jill A. Hadley, Susan M. Krzysik-Walker, K. Sandeep Prabhu, Regina Vasilatos-Younken, and Ramesh Ramachandran

Unique Profile of Chicken Adiponectin, a Predominantly Heavy Molecular Weight Multimer, and Relationship to Visceral Adiposity
Endocrinology 2009 150: 3092-3100 , doi:10.1210/en.2008-1558 [Abstract] [Full Text] [PDF]  
Adiponectin in chicken plasma and tissues is predominantly a heavy molecular weight isoform and contains hydroxyproline and lysine residues that are hydroxylated and glycosylated.

Andrea Peier, Jennifer Kosinski, Kimberly Cox-York, Ying Qian, Kunal Desai, Yue Feng, Prashant Trivedi, Nicholas Hastings, and Donald J. Marsh

The Antiobesity Effects of Centrally Administered Neuromedin U and Neuromedin S Are Mediated Predominantly by the Neuromedin U Receptor 2 (NMUR2)
Endocrinology 2009 150: 3101-3109 , doi:10.1210/en.2008-1772 [Abstract] [Full Text] [PDF]  
The neuromedin U receptor 2 (NMUR2) primarily mediates the reductions in food intake and body weight observed with central administration of NMU and NMS in mice.

GLUCOCORTICOIDS-CRH-ACTH-ADRENAL:

Satoshi Somekawa, Keiichi Imagawa, Noriyuki Naya, Yasuhiro Takemoto, Kenji Onoue, Satoshi Okayama, Yukiji Takeda, Hiroyuki Kawata, Manabu Horii, Tamio Nakajima, Shiro Uemura, Naoki Mochizuki, and Yoshihiko Saito

Regulation of Aldosterone and Cortisol Production by the Transcriptional Repressor Neuron Restrictive Silencer Factor
Endocrinology 2009 150: 3110-3117 , doi:10.1210/en.2008-1624 [Abstract] [Full Text] [PDF] [Supplemental Data]  
Transcriptional repressor NRSF regulates aldosterone and cortisol synthesis by binding neuron-restrictive silencer factor (NRSE) in CACNA1H gene and NRSEs in CYP11B2 and CYP11B1 genes in human H295R cells.

Cristina Núñez, Anna Földes, Domingo Pérez-Flores, J. Carlos García-Borrón, M. Luisa Laorden, Krisztina J. Kovács, and M. Victoria Milanés

Elevated Glucocorticoid Levels Are Responsible for Induction of Tyrosine Hydroxylase mRNA Expression, Phosphorylation, and Enzyme Activity in the Nucleus of the Solitary Tract during Morphine Withdrawal
Endocrinology 2009 150: 3118-3127 , doi:10.1210/en.2008-1732 [Abstract] [Full Text] [PDF]  
This study shows the dependence of tyrosine hydroxylase (TH) mRNA expression and TH activity in the NTS-A2 area on the elevated levels of glucocorticoids during morphine withdrawal.

GROWTH FACTORS-CYTOKINES:

Cédric Carli, Christine N. Metz, Yousef Al-Abed, Paul H. Naccache, and Ali Akoum

Up-Regulation of Cyclooxygenase-2 Expression and Prostaglandin E₂ Production in Human Endometriotic Cells by Macrophage Migration Inhibitory Factor: Involvement of Novel Kinase Signaling Pathways
Endocrinology 2009 150: 3128-3137 , doi:10.1210/en.2008-1088 [Abstract] [Full Text] [PDF]  
Migration inhibitory factor distinctly acts via p38 and ERK MAPK to stimulate COX-2 expression and PGE₂ secretion in ectopic endometrial cells, which may provide a novel mechanism underlying endometriosis development.

Akihiro Yasoda, Hidetomo Kitamura, Toshihito Fujii, Eri Kondo, Naoaki Murao, Masako Miura, Naotetsu Kanamoto, Yasato Komatsu, Hiroshi Arai, and Kazuwa Nakao

Systemic Administration of C-Type Natriuretic Peptide as a Novel Therapeutic Strategy for Skeletal Dysplasias
Endocrinology 2009 150: 3138-3144 , doi:10.1210/en.2008-1676 [Abstract] [Full Text] [PDF]  
Administration of C-type natriuretic peptide (CNP) rescues short stature and impaired bone growth of mice model of achondroplasia, indicating therapeutic potential of CNP for skeletal dysplasias.

Iori Ueki, Sarah L. Giesy, Kevin J. Harvatine, Jin Wook Kim, and Yves R. Boisclair

The Acid-Labile Subunit Is Required for Full Effects of Exogenous Growth Hormone on Growth and Carbohydrate Metabolism
Endocrinology 2009 150: 3145-3152 , doi:10.1210/en.2008-1740 [Abstract] [Full Text] [PDF]  
Growth hormone effects are attenuated in mice deficient for the acid-labile subunit.

Araní Casillas-Ramírez, Amine Zaouali, Susagna Padrissa-Altés, Ismail Ben Mosbah, Anna Pertosa, Izabel Alfany-Fernández, Maria Bintanel-Morcillo, Carme Xaus, Antoni Rimola, Juan Rodés, Joan Roselló-Catafau, and Carmen Peralta

Insulin-Like Growth Factor and Epidermal Growth Factor Treatment: New Approaches to Protecting Steatotic Livers against Ischemia-Reperfusion Injury
Endocrinology 2009 150: 3153-3161 , doi:10.1210/en.2008-1458 [Abstract] [Full Text] [PDF]  
IGF-I administration increased egf expression, which protected the liver against ischemia-reperfusion injury by reducing p38 activation in non-steatotic livers and inducing PPAR- overexpression in steatotic livers.

Parmeet K. Jodhka, Paramjit Kaur, Wendy Underwood, John P. Lydon, and Meharvan Singh

The Differences in Neuroprotective Efficacy of Progesterone and Medroxyprogesterone Acetate Correlate with Their Effects on Brain-Derived Neurotrophic Factor Expression
Endocrinology 2009 150: 3162-3168 , doi:10.1210/en.2008-1247 [Abstract] [Full Text] [PDF]  
While progesterone is protective and induces an increase in brain-derived neurotrophic factor (BDNF) levels, the synthetic progestin, medroxyprogesterone acetate, is not protective and does not increase BDNF expression.

GROWTH HORMONE-SOMATOSTATIN-GRH:

Erika Peverelli, Andrea G. Lania, Giovanna Mantovani, Paolo Beck-Peccoz, and Anna Spada

Characterization of Intracellular Signaling Mediated by Human Somatostatin Receptor 5: Role of the DRY Motif and the Third Intracellular Loop
Endocrinology 2009 150: 3169-3176 , doi:10.1210/en.2008-1785 [Abstract] [Full Text] [PDF]  
Two regions are identified in the i2 and i3 loop of the human SST5 required for the generation of downstream effectors involved in the regulation of hormone secretion and cell proliferation.

Raul M. Luque, Beatriz S. Soares, Xiao-ding Peng, Sonia Krishnan, Jose Cordoba-Chacon, Lawrence A. Frohman, and Rhonda D. Kineman

Use of the Metallothionein Promoter-Human Growth Hormone-Releasing Hormone (GHRH) Mouse to Identify Regulatory Pathways that Suppress Pituitary Somatotrope Hyperplasia and Adenoma Formation due to GHRH-Receptor Hyperactivation
Endocrinology 2009 150: 3177-3185 , doi:10.1210/en.2008-1482 [Abstract] [Full Text] [PDF] [Supplemental Data]  
Both cell cycle modulators and endogenous somatostatin tone exert restraining influences on the progression from GHRH-induced hyperplastic to adenomatous somatotropes and decreases in their activity over time removes this restraint, allowing for adenoma development.

NEUROENDOCRINOLOGY:

Lifei Liu, Junming Wang, Liqin Zhao, Jon Nilsen, Kelsey McClure, Karren Wong, and Roberta Diaz Brinton

Progesterone Increases Rat Neural Progenitor Cell Cycle Gene Expression and Proliferation Via Extracellularly Regulated Kinase and Progesterone Receptor Membrane Components 1 and 2
Endocrinology 2009 150: 3186-3196 , doi:10.1210/en.2008-1447 [Abstract] [Full Text] [PDF] [Supplemental Data]  
Progesterone promotes hippocampal neurogenesis via a membrane progesterone receptor/ERK signaling pathway and is a potential therapeutic target for promoting regeneration in brain.

Agatha Kokot, Dieter Metze, Nicolas Mouchet, Marie-Dominique Galibert, Meinhard Schiller, Thomas A. Luger, and Markus Böhm

-Melanocyte-Stimulating Hormone Counteracts the Suppressive Effect of UVB on Nrf2 and Nrf-Dependent Gene Expression in Human Skin
Endocrinology 2009 150: 3197-3206 , doi:10.1210/en.2008-1315 [Abstract] [Full Text] [PDF]  
-MSH counteracts UV-induced Nrf suppression.

Lee Niel, Amit H. Shah, Gareth A. Lewis, Kaiguo Mo, Diptendu Chatterjee, Shannon M. Fernando, Mei Hua Hong, William Y. Chang, Peter Vollmayr, Jon Rosen, Jeffrey N. Miner, and D. Ashley Monks

Sexual Differentiation of the Spinal Nucleus of the Bulbocavernosus Is Not Mediated Solely by Androgen Receptors in Muscle Fibers
Endocrinology 2009 150: 3207-3213 , doi:10.1210/en.2008-1478 [Abstract] [Full Text] [PDF]  
Expression of androgen receptors in muscle fibers is not sufficient for rescue of the sexually dimorphic spinal nucleus of the bulbocavernosus neuromuscular system.

Jenny Clarkson, Wah Chin Boon, Evan R. Simpson, and Allan E. Herbison

Postnatal Development of an Estradiol-Kisspeptin Positive Feedback Mechanism Implicated in Puberty Onset
Endocrinology 2009 150: 3214-3220 , doi:10.1210/en.2008-1733 [Abstract] [Full Text] [PDF]  
Estradiol is responsible for initiating kisspeptin expression in periventricular hypothalamic neurons that are thought to activate gonadotropin-releasing hormone neurons controlling puberty onset.

Stephanie Constantin, Alain Caraty, Susan Wray, and Anne H. Duittoz

Development of Gonadotropin-Releasing Hormone-1 Secretion in Mouse Nasal Explants
Endocrinology 2009 150: 3221-3227 , doi:10.1210/en.2008-1711 [Abstract] [Full Text] [PDF]  
Developing GnRH-1 neurons exhibit pulsatile secretion that correlates with synchronized somal calcium events and show maturation in secretory processes prior to entering the brain.

A. M. Barron, M. Cake, G. Verdile, and R. N. Martins

Ovariectomy and 17β-Estradiol Replacement Do Not Alter β-Amyloid Levels in Sheep Brain
Endocrinology 2009 150: 3228-3236 , doi:10.1210/en.2008-1252 [Abstract] [Full Text] [PDF]  
Estrogen depletion and supplementation do not alter Aβ accumulation or oxidative stress in sheep brain, a non-transgenic model for the study of sporadic Alzheimer’s disease.

Tamara Blutstein, Peter J. Baab, H. Ronald Zielke, and Jessica A. Mong

Hormonal Modulation of Amino Acid Neurotransmitter Metabolism in the Arcuate Nucleus of the Adult Female Rat: A Novel Action of Estradiol
Endocrinology 2009 150: 3237-3244 , doi:10.1210/en.2008-1701 [Abstract] [Full Text] [PDF] [Supplemental Data]  
A novel effect of estradiol on glutamate and GABA synthesis in the arcuate nucleus and its potential implications on homeostatic functions are discussed.

Cleyde V. Helena, De'Nise T. McKee, Richard Bertram, Ameae M. Walker, and Marc E. Freeman

The Rhythmic Secretion of Mating-Induced Prolactin Secretion Is Controlled by Prolactin Acting Centrally
Endocrinology 2009 150: 3245-3251 , doi:10.1210/en.2009-0095 [Abstract] [Full Text] [PDF]  
Prolactin stimulates a prolactin secretory rhythm.

George Vlotides, Yen-Hao Chen, Tamar Eigler, Song-Guang Ren, and Shlomo Melmed

Fibroblast Growth Factor-2 Autofeedback Regulation in Pituitary Folliculostellate TtT/GF Cells
Endocrinology 2009 150: 3252-3258 , doi:10.1210/en.2008-1625 [Abstract] [Full Text] [PDF]  
Targeted inhibition of FGF-2 positive auto-feedback mechanism in established cases of FS cell-dependent pituitary tumors could suppress excess intrapituitary growth factor activity and thus tumor cell growth.

REPRODUCTION-DEVELOPMENT:

Panayiotis Filis, Tamsin Lannagan, Ashley Thomson, Alison A. Murray, Peter C. Kind, and Norah Spears

Phospholipase C-β1 Signaling Affects Reproductive Behavior, Ovulation, and Implantation
Endocrinology 2009 150: 3259-3266 , doi:10.1210/en.2009-0214 [Abstract] [Full Text] [PDF] [Supplemental Data]  
Signaling via the plasma membrane enzyme PLC-β1 is involved in multiple aspects of reproduction, including behavior, ovulation, pre-implantation embryo development, and implantation.

Akhilesh K. Pandey, Xiangling Yin, Randolph B. Schiffer, James C. Hutson, Douglas M. Stocco, Paula Grammas, and XingJia Wang

Involvement of the Thromboxane A2 Receptor in the Regulation of Steroidogenic Acute Regulatory Gene Expression in Murine Leydig Cells
Endocrinology 2009 150: 3267-3273 , doi:10.1210/en.2008-1425 [Abstract] [Full Text] [PDF] [Supplemental Data]  
The thromboxane A2 receptor is involved in the COX2-dependent negative signaling that inhibits steroidogenic acute regulatory (StAR) gene expression and steroidogenesis in Leydig cells; blocking the receptor is able to delay the declines in StAR protein expression and testosterone biosynthesis in aging Leydig cells.

K. A. Walters, K. J. McTavish, M. G. Seneviratne, M. Jimenez, A. C. McMahon, C. M. Allan, L. A. Salamonsen, and D. J. Handelsman

Subfertile Female Androgen Receptor Knockout Mice Exhibit Defects in Neuroendocrine Signaling, Intraovarian Function, and Uterine Development But Not Uterine Function
Endocrinology 2009 150: 3274-3282 , doi:10.1210/en.2008-1750 [Abstract] [Full Text] [PDF] [Supplemental Data]  
AR^–/– female mice exhibit decreased fertility and ovulation due to defects in neuroendocrine and intra-ovarian mechanisms as well as uterine development but normal uterine function.

Tetsurou Satoh, Takahiro Ishizuka, Takuya Tomaru, Satoshi Yoshino, Yasuyo Nakajima, Koshi Hashimoto, Nobuyuki Shibusawa, Tsuyoshi Monden, Masanobu Yamada, and Masatomo Mori

Tat-Binding Protein-1 (TBP-1), an ATPase of 19S Regulatory Particles of the 26S Proteasome, Enhances Androgen Receptor Function in Cooperation with TBP-1-Interacting Protein/Hop2
Endocrinology 2009 150: 3283-3290 , doi:10.1210/en.2008-1122 [Abstract] [Full Text] [PDF]  
A component of 19S regulatory particles directly binds androgen receptor (AR) and might participate in AR-mediated transcriptional activation in cooperation with Tat-binding protein-1-interacting binding protein.

Jing Liu, Eun-Sil Park, and Misung Jo

Runt-Related Transcription Factor 1 Regulates Luteinized Hormone-Induced Prostaglandin-Endoperoxide Synthase 2 Expression in Rat Periovulatory Granulosa Cells
Endocrinology 2009 150: 3291-3300 , doi:10.1210/en.2008-1527 [Abstract] [Full Text] [PDF] [Supplemental Data]  
These findings provide experimental evidence that the LH-dependent induction of Ptgs2 expression results, in part, from RUNX1-mediated transactivation of the Ptgs2 promoter.

Hanzhou Wang, Rong Li, and Yanfen Hu

The Alternative Noncoding Exons 1 of Aromatase (Cyp19) Gene Modulate Gene Expression in a Posttranscriptional Manner
Endocrinology 2009 150: 3301-3307 , doi:10.1210/en.2008-1812 [Abstract] [Full Text] [PDF]  
Aromatase expression is controlled by a post-transcriptional mechanism.

Pulak R. Manna, Ilpo T. Huhtaniemi, and Douglas M. Stocco

Mechanisms of Protein Kinase C Signaling in the Modulation of 3',5'-Cyclic Adenosine Monophosphate-Mediated Steroidogenesis in Mouse Gonadal Cells
Endocrinology 2009 150: 3308-3317 , doi:10.1210/en.2008-1668 [Abstract] [Full Text] [PDF]  
Protein kinase C modulates cAMP/PKA-mediated steroidogenesis and thus plays an important role in controlling gonadal development and function.

J. Dinny Graham, Patricia A. Mote, Usha Salagame, Jessica H. van Dijk, Rosemary L. Balleine, Lily I. Huschtscha, Roger R. Reddel, and Christine L. Clarke

DNA Replication Licensing and Progenitor Numbers Are Increased by Progesterone in Normal Human Breast
Endocrinology 2009 150: 3318-3326 , doi:10.1210/en.2008-1630 [Abstract] [Full Text] [PDF] [Supplemental Data]  
Progesterone augments proliferation of normal human breast epithelial cells in matrix-embedded culture by activating DNA replication licensing and kinetochore formation, and by increasing bipotent progenitor numbers.

Y. Sangeeta Devi, Aurora Shehu, Carlos Stocco, Julia Halperin, Jamie Le, Anita M. Seibold, Michal Lahav, Nadine Binart, and Geula Gibori

Regulation of Transcription Factors and Repression of Sp1 by Prolactin Signaling Through the Short Isoform of Its Cognate Receptor
Endocrinology 2009 150: 3327-3335 , doi:10.1210/en.2008-1719 [Abstract] [Full Text] [PDF] [Supplemental Data]  
Prolactin signaling through PRL-RS in ovarian and decidual cells does not activate the Jak2/Stat pathway in vivo, but leads to severe repression of Sp1 transcription factor.

Erica R. Siu, Elissa W. P. Wong, Dolores D. Mruk, K. L. Sze, Catarina S. Porto, and C. Yan Cheng

An Occludin-Focal Adhesion Kinase Protein Complex at the Blood-Testis Barrier: A Study Using the Cadmium Model
Endocrinology 2009 150: 3336-3344 , doi:10.1210/en.2008-1741 [Abstract] [Full Text] [PDF] [Supplemental Data]  
Focal adhesion kinase (FAK) is an integrated regulatory component of the occludin-ZO-1 protein complex, suggesting functional studies can be performed to study the role of FAK in blood-testis barrier dynamics.

Rieko Yodoi, Shigero Tamba, Kazushi Morimoto, Eri Segi-Nishida, Mika Nishihara, Atsushi Ichikawa, Shuh Narumiya, and Yukihiko Sugimoto

RhoA/Rho Kinase Signaling in the Cumulus Mediates Extracellular Matrix Assembly
Endocrinology 2009 150: 3345-3352 , doi:10.1210/en.2008-1449 [Abstract] [Full Text] [PDF] [Supplemental Data]  
Chemokines induce cumulus cell rounding and extracellular matrix assembly through the Rho/ROCK/actomyosin pathway within the oviduct.

Tadashi Matsumoto, Kazuhiro Minegishi, Hitoshi Ishimoto, Mamoru Tanaka, Jon D. Hennebold, Takahide Teranishi, Yoshihisa Hattori, Masataka Furuya, Takayuki Higuchi, Satoshi Asai, Seon Hye Kim, Kei Miyakoshi, and Yasunori Yoshimura

Expression of Ovary-Specific Acidic Protein in Steroidogenic Tissues: A Possible Role in Steroidogenesis
Endocrinology 2009 150: 3353-3359 , doi:10.1210/en.2008-1584 [Abstract] [Full Text] [PDF]  
The results suggest that ovary-specific acidic protein is involved in steroidogenesis, potentially through its ability to maintain mitochondrial abundance and morphology.

Zhilin Liu, Daniel G. de Matos, Heng-Yu Fan, Masayuki Shimada, Stephen Palmer, and JoAnne S. Richards

Interleukin-6: An Autocrine Regulator of the Mouse Cumulus Cell-Oocyte Complex Expansion Process
Endocrinology 2009 150: 3360-3368 , doi:10.1210/en.2008-1532 [Abstract] [Full Text] [PDF] [Supplemental Data]  
IL-6 is induced in cumulus cells of ovulating follicles where it can serve as an autocrine regulator of specific genes, COC expansion, and oocyte competence.

Kevin Mouzat, Fanny Volat, Silvère Baron, Georges Alves, Aurélien J. C. Pommier, David H. Volle, Geoffroy Marceau, Angélique DeHaze, Pierre Déchelotte, Raj Duggavathi, Françoise Caira, and Jean-Marc A. Lobaccaro

Absence of Nuclear Receptors for Oxysterols Liver X Receptor Induces Ovarian Hyperstimulation Syndrome in Mice
Endocrinology 2009 150: 3369-3375 , doi:10.1210/en.2008-1519 [Abstract] [Full Text] [PDF]  
Female mice lacking nuclear receptors for oxysterols LXR develop many biological and clinical signs of ovarian hyperstimulation syndrome when undergoing an ovulation induction treatment.

Jason G. Bromer, Jie Wu, Yuping Zhou, and Hugh S. Taylor

Hypermethylation of Homeobox A10 by in Utero Diethylstilbestrol Exposure: An Epigenetic Mechanism for Altered Developmental Programming
Endocrinology 2009 150: 3376-3382 , doi:10.1210/en.2009-0071 [Abstract] [Full Text] [PDF]  
We identify hypermethylation as a novel mechanism of diethylstilbestrol induced altered developmental programming.

Kyeong-Hoon Jeong, John C. Gill, Vania Nosé, Albert F. Parlow, Rona S. Carroll, and Ursula B. Kaiser

Expression of a Gonadotropin-Releasing Hormone Receptor-Simian Virus 40 T-Antigen Transgene Has Sex-Specific Effects on the Reproductive Axis
Endocrinology 2009 150: 3383-3391 , doi:10.1210/en.2008-1362 [Abstract] [Full Text] [PDF] [Supplemental Data]  
Transgenic targeting of SV40 T antigen in gonadotropes results in female-specific infertility due to disruption of gonadotropin production and secretion, even prior to tumor development.

Jaeyeon Kim, Indrani C. Bagchi, and Milan K. Bagchi

Signaling by Hypoxia-Inducible Factors Is Critical for Ovulation In Mice
Endocrinology 2009 150: 3392-3400 , doi:10.1210/en.2008-0948 [Abstract] [Full Text] [PDF]  
The hypoxia-inducible factors act downstream of progesterone receptor in the ovarian granulosa cells and play a critical role during ovulation in mice.

THYROID-TRH-TSH:

Chun-Rong Chen, Sandra M. McLachlan, and Basil Rapoport

A Monoclonal Antibody with Thyrotropin (TSH) Receptor Inverse Agonist and TSH Antagonist Activities Binds to the Receptor Hinge Region as Well as to the Leucine-Rich Domain
Endocrinology 2009 150: 3401-3408 , doi:10.1210/en.2008-1800 [Abstract] [Full Text] [PDF]  
The discontinuous epitope of CS-17, a TSH receptor mAb with inverse agonist and TSH antagonist activities, includes a component in the TSH receptor hinge, expanding our present concept of glycoprotein hormone binding and function.

Hiroaki J. Kimura, Roberto Rocchi, Melissa A. Landek-Salgado, Koichi Suzuki, Cindy Y. Chen, Miho Kimura, Noel R. Rose, and Patrizio Caturegli

Influence of Signal Transducer and Activator of Transcription-1 Signaling on Thyroid Morphology and Function
Endocrinology 2009 150: 3409-3416 , doi:10.1210/en.2008-1769 [Abstract] [Full Text] [PDF] [Supplemental Data]  
STAT1 mediates in the thyroid some, but not all, of the effects induced by IFN, and regulates iodine accumulation via TGFβ signaling.

Koshi Hashimoto, Emi Ishida, Shunichi Matsumoto, Shuichi Okada, Masanobu Yamada, Teturou Satoh, Tsuyoshi Monden, and Masatomo Mori

Carbohydrate Response Element Binding Protein Gene Expression Is Positively Regulated by Thyroid Hormone
Endocrinology 2009 150: 3417-3424 , doi:10.1210/en.2009-0059 [Abstract] [Full Text] [PDF]  
Mouse and human carbohydrate response element-binding protein gene expression is positively regulated by thyroid hormone in liver at the transcriptional levels, indicating the hormone fine-tunes hepatic lipogenesis.

Ryohei Umezawa, Masanobu Yamada, Kazuhiko Horiguchi, Sumiyasu Ishii, Koshi Hashimoto, Shuichi Okada, Teturou Satoh, and Masatomo Mori

Aberrant Histone Modifications at the Thyrotropin-Releasing Hormone Gene in Resistance to Thyroid Hormone: Analysis of F455S Mutant Thyroid Hormone Receptor
Endocrinology 2009 150: 3425-3432 , doi:10.1210/en.2008-1738 [Abstract] [Full Text] [PDF] [Supplemental Data]  
Negative regulation of the gene by thyroid hormone involves both the acetylation and methylation of histone tails, and the major impairment in F455S was hyperacetylation.

ARTICLES:

Panagiotis Anagnostis, Vasilios G. Athyros, Konstantinos Tziomalos, Asterios Karagiannis, and Dimitri P. Mikhailidis

The Pathogenetic Role of Cortisol in the Metabolic Syndrome: A Hypothesis
Endocrinology 2009 150: 3433 [Full Text] [PDF]  

J. Frystyk, D. J. Brick, A. V. Gerweck, A. L. Utz, and K. K. Miller

Bioactive IGF-I in Obesity
Endocrinology 2009 150: 3433-a [Full Text] [PDF]  

John J. Peluso, Xiufang Liu, Anna Gawkowska, and Erika Johnston-MacAnanny

Progesterone Activates a Progesterone Receptor Membrane Component 1-Dependent Mechanism That Promotes Human Granulosa/Luteal Cell Survival But Not Progesterone Secretion
Endocrinology 2009 150: 3434 [Full Text] [PDF]  

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